Blood coagulation – clotting factors in blood. General mechanism of blood coagulation. Intrinsic and extrinsic pathway for initiation of clotting. Disorders in the hemostasis

Question 1

blood coagulation - definition

Answer 1

to maintain constant blood flow

whilst preventing blood loss after cut

Question 2

blood coagulation - factor 1

Answer 2

fibrinogen
- to be converted into fibrin via thrombin
- to stabilise blood clot

Question 3

blood coagulation - factor 2

Answer 3

prothombin
- to be converted into thrombin by prothrombinase

Question 4

blood coagulation - factor 3

Answer 4

tissue factor/ thromboplastin

combines with factor 7a -> factor X -> thrombin

Question 5

blood coagulation - factor 4

Answer 5

= calcium ions

acts as cofactor in extrinsic + intrinsic pathway

Question 6

blood coaggulation - factor 5

Answer 6

proaccerelin labile factor

combines with calcium / phospholipids to activate prothrombinase

Question 7

blood coagulation - factor 7

Answer 7

proconvertin factor

activated by tissue factor
activates factor X

for extrinsic pathway

Question 8

blood coagulation - factor 8

Answer 8

antihemophilic factor

deficiency gonna cause hemophilia A

Question 9

blood coagulation - factor 9

Answer 9

christmas factor

deficiency causes hemophilia B

Question 10

blood coaggulation factor 10

Answer 10

stuart prower factor

converts promthrombin to thrombin

Question 11

blood coaggulation factor 11

Answer 11

plasma thromboplastin antecedent

= acts as cofactor for factor 9 for intrinsic pathway

Question 12

blood coaggulation factor 12

Answer 12

hageman factor

• activates factor 11

Question 13

blood coaggulation factor 13

Answer 13

= fibrin stabilising factor

cross-links fibrin to stabilise clot

Question 14

disorder - 1

Answer 14

hemophilia A
- deficiency of factor 8
- spontaneous bleeding / bruising

Question 15

disorder - 2

Answer 15

hemophilia B
- deficiency of factor 9

Question 16

disorder - 3

Answer 16

vWF disease

deficiency of vWF = no platelet adhesion = easily bruising

Question 17

disorder - 4

Answer 17

thrombocytopenia

= low platelet count

• automimmune/ bone marrow disorder

Question 18

disorder - 5

Answer 18

deep vein thrombosis
- blood clot formed deep in vein
- blood clot can break off -> reach lungs -> pulmonary embolism

Question 19

disorder - 6

Answer 19

thrombophilia = tendency to form abnormal clots

Question 20

disorder - 7

Answer 20

antiphospholipid disease
- antibodies increase risk of blood clots in artery/ vein