Blood Coagulation

Question 1

Heparin inhibits what factors?

Answer 1

IIa, IX, and Xa

Question 2

What does the Activated Partial Thromboplastin Time (APTT or PTT) measure?

Also, what is its reference range?

Answer 2

APTT: Measures the instrinsic and and common pathways.

Reference Time: 25-35 seconds

Question 3

What clinical test(s) are used to monitor Heparin therapy as compared to Coumadin Therapy?

Answer 3

Heparin Therapy: APTT (Intrinsic and Common)

Coumadin: Prothrombin Time (PT)

Question 4

What are the pathways tested w/ PT (Prothrombin Time)?

Also, what is the reference range?

Answer 4

PT: Extrinsic & Common

Reference: 10-13 seconds