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CP Final Exam F'16 > ANS Pharmacology > Flashcards

ANS Pharmacology Flashcards

1
Q

What is the location of Action for Dopamine?

A

Dopamine: Acts on the CNS and Renal Vascular Smooth Muscle

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2
Q

What is the action of Histamine on mACHRs?

A

It blocks the ability of sweat glands to function

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3
Q

What is the location of action regarding a M1 receptor?

A

CNS, Ganglia

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4
Q

What is the location of action regarding M2 receptor?

A

Heart, Nerves, Smooth Muscle

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5
Q

What is the location of action regarding M3 Receptor?

A

Glands, Smooth Muscle, and Endothelium

GSE! The G3!

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6
Q

What is the location of action regarding M4 Receptor?

A

CNS

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7
Q

What is the location of action regarding M5 Receptor?

A

CNS

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8
Q

What is different about the use of Epinephrine as a NT?

A

It is only synthesized in vesicles located in/near the Adrenal Medulla

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9
Q

What is the major NT for Sympathetic Nervous System?

A

Noriepinephrine

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10
Q

What is the transporter that transports Tyrosine into the nerve terminal?

A

Na+-Dependent Tyrosine Transporter

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11
Q

What is the transporter that transports NE, Epi, DA (Dopamine), and Serotonin into the vesicles?

A

Vesicular Monoamine Transporter (VMAT-2)

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12
Q

What is the transporter that transports NE into the nerve terminal?

A

NE Transporter (NET)

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13
Q

What is the Main mechanism of termination of catecholamine signaling?

A

1) Reuptake into nerve terminals
Via: NET (NE) & DAT (DA)
After reuptake; the NTs are stored in vesicles via VMAT-2

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14
Q

What are the two main enzymes involved in the breakdown of NTs?

A

MOA (monoamine oxidase) & COMT (Catechol-O-methyltransferase)

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15
Q

What is the 1) GPCR 2) Agonists 3) Tissue and Response for Alpha 1 Receptor?

A

1) Gq (PLC, IP3, DAG, Ca2+)
2) Epi > NE
3) Vascular SM: Contraction / Heart: Increased contractile force

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16
Q

What is the 1) GPCR 2) Agonists 3) Tissue and Response for Alpha 2 Receptor?

A

1) Gi (Decreased AC, cAMP)
2) Epi > NE
3) Platelets: Aggregation / Vascular Smooth Muscle: Contraction

17
Q

What is the 1) GPCR 2) Agonists 3) Tissue and Response for Beta 1 Receptor?

A

1) Gs (Increased AC, cAMP, L-type Ca2+ Channel)
2) Epi = NE
3) Heart: Increased FOC & HR

18
Q

What is the 1) GPCR 2) Agonists 3) Tissue and Response for Beta 2 Receptor?

A

1) Gs (Increased AC)
2) NE > Epi
3) Smooth Muscle: Relaxation / Skeletal Muscle: Glycogenolysis

19
Q

What is the effect of Muscarinic Receptors on smooth muscle?

A

1) Contraction of SM

20
Q

What is the effect of ACH and Muscarinic Receptors given IV?

A

Vasodilation d/t release of NO

21
Q

What is the only innervation of Vascular smooth muscle?

A

Adrenergic receptors.

Vascular smooth muscle is not innervated by parasympathetic neurons

22
Q

What is the effect of activation of mACHRs on Endothelial cells?

A

1) Causes production of EDRF –> Produces NO

CP Final Exam F'16 (7 decks)

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