Blood Brain Barrier Flashcards

1
Q

% of the brain the ECF makes up

A

15-20

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2
Q

How does the brain control the composition of the ECF

A
  • through CSF
  • BBB protecting it from changes in blood composition
  • glial cells conditioning the ECF
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3
Q

Name 5 functions of the CSF

A
  1. removes waste e.g. lactate
  2. acts as a cushion
  3. medium between ECF and blood
  4. right environment for neurones
  5. interface between brain and peripheral endocrine organs
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4
Q

How is CSF producted

A

ultrafiltration of plasma across fenestrated capillary into ECF in contact with basolat memb of CEC. choroid epithelial cells secreting fluid into the ventricles

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5
Q

describe what happens in the basolat membranes and the apical membranes

A

basolat- Na+ in causes H+ out. This causes HCO3 out and Cl IN
apical - 3Na out 2K in . electrochemical gradient causing HCO3- and CL- to leave cell INTO CSF

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6
Q

What is virchow robin space

A

filled with CSF. vessels take pia with them when they go into brain. cells lining have leaky junctions to allow the CSF and ECF to interact

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7
Q

how does the CSF interact with glia and neurones

A

via ECF

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8
Q

name two clinical uses of CSF for diagnosis

A

pathogens e.g. meningitis

hydrocephalus + sub arachnoid haemorrhage

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9
Q

name 3 factors that regulate the BBB and 2 properties of the BBB that enable this

A

lipid solubility, ionisation, plasma protein binding

tight junctions and net fenestrating

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10
Q

How does Dglucose Lleucine and Ldopa cross the BBB

A

through facilitated transport

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11
Q

How does the BBB effect parkinsons treatment and how do you get around this

A

L DOPA and a peripheral decarboxylase inhibitor - preventing conversion of ldopa to dopamine outside the brain. dopamine cant cross the BBB as its ionised at ph7.4

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12
Q

Name of the brain areas with a leaky the BBB

A

circumventricular organs

  1. post pituitary
  2. median eminence
  3. OVLT
  4. area postrema
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