Blood 4 Flashcards

1
Q

neutrophil function

A

combat pyogenic infections

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2
Q

eosinophils function

A

fight alltergies and parasitic infections

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3
Q

basobphil function

A

function is to fight hypersensitivity reactions, parasitis infections

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4
Q

lymphocyte function

A

fight viral infections (measles, rubella, cheickenpox, mono)

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5
Q

monocyte function

A

help neutrophils

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6
Q

what do basophils contain? why?

A

histamine, heparine, etc

for immediate hypersensitivity reactions

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7
Q

what do eosinophils contain?

A

proteolytic enzymes

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8
Q

where do we find eosinophils

A

mostly in tissues, not blood

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9
Q

what do neutrophils contain? why?

A

acid phosphatase
acid hydrolase
peroxidase
for phagocytic action

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10
Q

what are granulocytes?

A

cells that contain granules

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11
Q

what are the types of granulocytes?

A

neutrophils
eosinophils
basophils

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12
Q

leukocytosis

A

WBC count above 10,000

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13
Q

what is leukocytosis due to?

A

increase in one of the 5 types of WBCs

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14
Q

neutrophiic leukocytosis

A

neutrophilia

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15
Q

lymphocytic leukocytosis

A

lymphocytosis

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16
Q

eosinophilic leukocytosis

A

eosinophilia

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17
Q

monocytic leukocysosis

A

monocytosis

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18
Q

basophilic leukocytosis

A

basophilia

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19
Q

leukocytosis >10,000 can be due to?

A
infection
inflammation
tissue necrosis
stress
strenuous eercise
corticosteroids, lithium, beta agonists
trauma (splenctomy)
leukemoid reactions
leukemia
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20
Q

leukopenia <5,000 can be due to?

A
virus
overwhelming bacterial infections
bone marrow disorders
antimetabolites
barbituates
antibiotics
anticonvulsants
antithyroid drugs
arsenicals
antineoplastics
cardiovascular drugs
diuretics
analgesics
anti-inflammatory drugs
heavy metal intoxication
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21
Q

WBCs

A

form the first line of defense of the body from invading microorganisms

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22
Q

what is the difference between RBCs and WBCs?

A

WBCs have a nucleus

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23
Q

what are the types of nongranulocytes?

A

lymphocytes

monocytes

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24
Q

leukopoiesis

A

process by which WBCs differeniate and proliferate

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25
development of leukocytes occurs primarily in?
bone marrow | lymphocytes can also develop in
26
how long does it take for granulocytes to be released into the peripheral blood?
14 days
27
neutrophils contain
acid phosphatase, acid hydrolase, peroxidase (essential from phagocytic action
28
eosinophils contain
contain proteolytic enzymes
29
function of eosinophils
allergy, drug reaction and parasites
30
where are eosinophils primarily?
tissue cells (not common in blood)
31
basophils contain
histamine, heparin, etc
32
what is the function of basophils?
immediate hypersensitivity reaction, parasitic reactions
33
neutrophil function
combat pyogenic infections
34
function of lymphocytes
function to fight viral infections (measles, rubella, chicken pox, mono)
35
monocytes function
help neutrophils
36
bacterial infections are generally _____than viral infections
worse
37
what will the tech do for WBC differentials?
stain the blood smear so a differential count can be done | count 100 cells to arrive at a differential
38
leukopenia
decreased WBCs | less than 5,000
39
leukopenia is seen with?
virus drugs, overwhelming bacterial infections and debilitated states antibiotic therapy bone marrow failure
40
leukocytosis
increased WBCs
41
leukocytosis can be due to?
infection, inflammation, tissue necrosis, leukemoid reaction, leukemia, trauma, stress, etc
42
leukemoid reaction
mimics CML greater than 20,000, less than 50,000 shift to the left is observed
43
leukemias are typically greater than..?
50,000
44
right shift indicates?
mature cells
45
left shift indicates?
more immature cells | increases in metamyelocytes, myelocytes, promyelocytes, blasts and bands
46
metamyelocytes mature into?
neutrophil bands, eosinophil bands, basophil bands
47
lymphocyte maturity steps
``` stem cells lymphoblast prolymphocyte large lymphocytes small lymphocyte ```
48
monocyte maturity steps
stem cell monoblast promonocyte monocyte
49
what are other names for neutrophils?
segs polymorphonuclear neutrophils polys
50
neutrophilia
increase in neutrphils usually
51
neutrophilia is due to?
bacterial infections, may also be due to inflammation, tissue destruction may also be increased after severe exercise, stress and hypoxia, myelogenous leukemia, neutrophilic leukemoid reactions may be due to some parasitic, fungal and some viral infections
52
neutropenia
decrease in neutrophils overwhelming bacterial infections and viral infections
53
toxic granules (granulation)
seen with infections, burns, malignancy and chemical poisoning
54
toxic vacuoles are seen with
septicemia, severe infections and toxic states, sign of degeneration
55
hypersegmented neutrophils are seen with?
megaloblastic anemia
56
16 WBCs indicates
leukocytosis in reaction to infection/inflammation
57
78 segs indicate
neutrophilia likely in response to bacteria
58
10 bands indicate
shift to the left
59
12 lymphs indicate
lymphopenia
60
bands/stab cells are
non functional
61
mature neutrophils + immature bands=?
shift to the left seen with infection/inflammation
62
types of lymphocytes
B and T lymphocytes
63
B lymphocytes
tag foreign bodies and antibody production
64
T lymphocytes
kill foreign bodies migrate to the thymus to proliferate T helper and T suppressor cells migrate to lymphoid tissue and represent the majority of lymphoid cells
65
where do lymphocyte precursors mature?
bone marrow
66
types of T cells
``` helper T cells NK T cells suppressor T cell cytotoxic T cell memory T cell regulatory T cell gamma delta T cell ```
67
where do B lymphocytes mature?
bone marrow, then released to lymph nodes, spleen, lymphoid tissue
68
final maturation of B lymphocytes are?
plasma cells
69
B lymphocytes have what kind of immunity?
humoral immunity and antibody production in response to antigen
70
T lymphocytes have what kind of immunity?
cellular immunity, tumor supression, protect from intracelular organisms