Blood Flashcards
clusters/nests near sinusoids contain ___
clusters/nests away from sinusoids contain ___
RBC & megakaryocytes
granulocytes
associated with allergic reactions, release histaminase
also associated with helminthic & protozoan infections, chronic inflammation
eosinophils
produced by liver & plasma cells, help attack viruses/bacteria & transport iron, lipids, and vitamins
ie antibodies
globulins
how many oxygen molecules bind per hemoglobin protein?
4
Identify cell type.

Basophil
CLPs give rise to ___ cells, and migrate from bone marrow to ___ or ____ where they differentiate.
lymphoid
thymus or lymphoid tissue (lymph nodes)
Identify cell type.
narrow rim of cytoplasm around edges, very dark nucleus that takes up most of the cell

Lymphocyte
what is function of hematopoeisis?
to maintain constant level of different cell types in blood
Identify cell type.
small faint lavender granules, dark nucleus with several lobes, larger than RBC

Neutrophil
these cells stain same color as RBC (acidophilic)
eosinophils
these cells come out of blood stream, work in tissues for defense and repair of injured tissue
leukocytes (WBC)
Identify.

sinusoids
Identify cell type.

Eosinophil
theory that all blood cells arise from a single type of pluripotent stem cell known as a hempatopoietic stem cell
Monophyletic Theory
this cell contains no nucleus, its main function is transportation of respiratory gases
erythrocyte (RBC)
associated with allergic reactions releasing histamine & other vasoactive agents, hypersensitivity
basophils
these cells undergo successive endomitoses to form megakaryocytes.
megakaryoblasts
Identify cell type.

Neutrophil
Identify cell type.
large coarse basophilic granules, light nucleus with 2 lobes

Basophil
T cells travel to ___ to complete differentiation.
B cells mature in the ____.
NK cells mature in the ____.
thymus
bone marrow
bone marrow
formed elements of blood all arise via…
hemopoietic stem cells
Identify cell type.

Monocyte
shape of erythrocyte?
diameter?
biconcave disc
7.8 micrometers
progenitor cells develop into ____ or ____ cells, which mark the beginning of morphologic differentiation
precursor, blast
cell fragments in blood, main function is for clotting
platelets (thrombocytes)
Identify cell type.

erythrocyte
Each heme group on hemoglobin molecule contains…
1 iron atom
do not contain specific granules, nuclei are rounded or indented, also contain azurophilic granules
mononuclear agranulocytes
3 granulocytes are ___, ___, ____
2 agranulocytes are ___, ___
granulocytes = “phils” (basophil, eosinophil, neutrophil)
agranulocytes = “cytes” (lymphocyte, monocyte)
main protein of blood- produced in liver, regulates vascular osmotic pressure (correct amount of water in blood)
albumin
Order of leukocytes in order from most numerous in blood stream to least numerous?
“Never Let Monkeys Eat Bananas”
Neutrophils
Lymphocytes
Monocytes
Eosinophils
Basophils
only true cell in blood, main function is protection
leukocytes (WBC)
Identify cell type.
large coarse acidophilic granules, light nucleus with 2 lobes

Eosinophil
Identify cell type.

neutrophil
at what stage is a cell committed to becoming a RBC?
at the blast stage (proerythroblast)
where does hematopoeisis occur in fetus?
where does it occur after birth?
yolk sac (1st trimester), liver (2nd trimester), bone marrow (3rd trimester)
red bone marrow
produced by liver, important for clotting
fibrinogen
where are RBC produced?
red bone marrow
What helps regulate hematopoiesis?
hormones & colony stimulating factors (CSFs)
when blood is centrifuged, ___ sits on top & ___ sinks to bottom. These two layers are separated by ____.
plasma
hematocrit (RBC)
buffy coat (WBC & platelets)
Identify where hematopoesis is occuring in graph at 1, 2, 3.

1- yolk sac
2- liver
3- bone marrow
watery ECM that dissolves blood components
plasma
Identify cell type.

basophil
Identify cell type.

megakaryocytes
mature cells exhibit no ____ activity
mitotic
most numerous cell in blood
erythrocytes (RBC)
2 classes of leukocytes
polymorphic granulocytes
mononuclear agranulocytes
Identify cell type.

eosinophil.
produce and circulate antibodies
B lymphocytes
Identify 1-4.

- platelet
- white blood cell
- red blood cell
- plasma
In bone marrow, these consist of developing blood cells, macrophages, mast cells, adipose cells
hemopoietic cords
Identify cell type.
gray “foamy” texture of cytoplasm, dark nucleus that is off-center, kidney or horseshoe-shaped

Monocyte
life span of erythrocyte?
120 days
best display to see all cell types in peripheral blood- put drop on a slide, pull it across to get monolayer of cells
blood smear
Identify cell type.

Lymphocyte
plasma is composed of 92% __, 7% ___ and 1% __ by weight.
water
proteins
solutes
extensions into sinusoids that penetrate the epithelium and pinch off to form platelets
proplatelets
immunoregulation, chronic inflammation- associated with immune system
lymphocytes
CMPs give rise to ___ cells, and develop in the ___
myeloid
bone marrow
pus is actually an accumulation of these dead cells
neutrophils
hemoglobin is composed of…
4 globin polypeptide chains, 4 heme groups
functions of blood
distribution- delivery of oxygen & nutrients regulation- thermoregulation, buffering protection- coagulation, protect from pathogens
includes methylene blue & azures which are basic, and eoisin which is acidic- helps stain blood smear
Wright’s Stain
general description of how RBC matures?
1st has lots of RER- bag of hemoglobin, very basophilic
then becomes eosinophilic- stains pink
last stage, nucleus gets kicked out
3 types of lymphocytes?
B lymphocytes
T lymphocytes
Natural Killer cells
transform into macrophages, precursors to phagocytic cells of body (ie osteoclasts), 2nd on scene
monocytes
these cells promote blood clotting and help repair minor tears or leaks in walls of blood vessels
thrombocytes (platelets)
what cell is unique to the neutrophil pathway?
band cell
where does oxygen bind in hemoglobin?
to iron atom
main component of erythrocyte
hemoglobin
Identify cell type

Monocyte
Identify cell type.

Lymphocyte
life span of platelet?
5-10 days
active phagocytes of bacteria, responsible for acute inflammation, 1st on scene
neutrophils
involved in cell-mediated immunity
T Lymphocytes
what cells are platelets derived from?
megakaryocytes
as you age, ___ marrow converts to ___ marrow
red
yellow
contain specific granules & nuclei have 2 or more lobes, also contain azurophilic granules
polymorphonuclear granulocytes
these are the support cells in bone marrow, stimulate differentiation of progenitor cells
adventitial/ reticular cells
2 major cell lineages that can come from HSC (hemopoietic stem cell)?
CMP or CLP
kill certain virus-infected cells and some types of tumor cells
natural killer cells
neutrophils, eosinophils, and basophils are all ___.
lymphocytes & monocytes are both ____.
polymorphonuclear granulocytes
mononuclear agranulocytes