Block 2 Flashcards
Which kidney is farther behind?
Left kidney (left behind)
What is a nephrotomy?
Cutting into the kidney
What are the 7 indications for a nephrotomy?
Renal calculi
Persistent hydronephrosis
Persistent hematuria
Mass / neoplasia
Trauma
Infection
Donation
What are the 3 highest risks for a nephrotomy?
Hemorrhage
Damage to kidney
Increased kidney values
Where do you ligate the ureter during a nephrectomy?
At the trigone
What are the 2 indications for a sub-ureteral bypass system (SUBs)
Ureteroliths within renal pelivis dilation
Ureteral stricture
What needle is used for SUBs?
Huber needles
What are the 3 complications with SUBS
Urine leakage
Encrusting of the nephrostomy tube or cystotomy tube
Infection
Describe how to perform a uretertomy?
Incise over inciting cause and remove stones
What are the 2 complications with ureterotomy?
Stricture and dehiscence
What does a ureteral stent do?
Placed from kidney to bladder to treat stones, strictures, or neoplasia
What are the 4 complications of ureteral stents?
Continued infection
Stent migration
Trauma to ureter
Urinary leakage
What is an ectopic ureter?
Ureter that is entering in abnormal location into bladder or directly into the urethra
What are extramural ectopic ureters?
Ectopic ureter that bypasses the bladder completely
What are the treatment options for extramural ectopic ureters?
Surgery only
What are the treatment options for intramural (enter bladder) ectopic ureters?
Laser ablation OR surgery
What are the 2 surgical options for ureteral reimplement?
End to side
Side to side
What is the non surgical approach to correcting a ectopic ureter?
Laser ablation
-Cystoscopy and a laser to tunnel to the level of the bladder
What is the surgery of the ectopic ureter called?
Neuorecterocystotomy
What does a end to side neuorecterocystotomy look like?
Cut ureter and implant via a stab incision into the bladder
What does a side to side neuorecterocystotomy look like?
Incise into bladder and through the bladder incise into the ureter
What are the 4 complications with these surgeries?
Strictures
Uroabdomen
Infections
Incontinence
Where do the ureters enter the bladder?
Dorsolaterally
Where does the vascular supply enter the bladder?
Dorsally
What is the main artery of the bladder?
Caudal vesical artery
What is really important to know about the anatomy of the bladder?
**Nerves, ureters, and blood supply of the bladder all enter dorsally!!!
What is the singular most common surgical bladder disease?
Urolithiasis
What can urolithiasis cause secondary?
UTIs
What are the top 3 most common surgical diseases of the bladder?
Urolithiasis
Trauma
Masses (polyps or neoplasia)
What are the 2 options for treatment of urolithiasis?
Medical and interventional
What is the medical therapy for urolithiasis?
Dissolution
What are the only 3 stones you can dissolve?
Struvite, urate, and cystine
What is lithotripsy?
Breaking apart with a laser
What is the minimum urethral size for lithotripsy?
5 French
What is the holding layer for the bladder?
Submucosa
How fast does the mucosa of the bladder heal?
5-7 days
How fast does it take for the bladder to get to full strength?
14-21 days
How much of the bladder can you take?
75%
Which direction of the bladder should you never cut?
On the dorsal side!
What is the most common bladder surgery?
Cystotomy
What suture type do you use for a cystotomy?
Monocryl
How many layers do you need to close the bladder?
Can do just the submucosa (holding layer)
What is another more advanced surgical option for urolithiasis?
PCCL = percutaneous cystolithotomy
What should you do immediatly post surgery for urolithiasis?
Radiographs!
What is seen on bloodwork for uroabdomen?
Azotemia
Dehydration (High USG, albumin, PCV/TP)
Metabolic acidosis
Hyperkalemia
What can you not use when comparing fluid in abdomen to blood when determining uroabdomen?
BUN, reaches even osmolality quickly
What should you see being HIGH in abdominal fluid in a uroabdomen compared to blood?
Creatinine and potassium
Where are masses most common in the bladder?
Trigone
What is the most common neoplasia of the bladder?
Transitional cell carcinoma
What is the widest diameter of male urethra?
2mm (pre and post prostatic)
What is diameter of male urethra at bulbourethral glands?
1.3mm
What is diameter of male urethra at end?
0.7mm
Are uroliths more common in dogs or cats?
Dogs
What is the most common surgical option for urethral uroliths?
urethrostomy (not urethrotomy)
What is a urethrotomy?
Creation of temporary opening in urethra
What type of urethrotomy/urethrostomy do dogs get?
Scrotal
What type of urethrotomy/urethrostomy do cats get?
Perineal
Why perform a urethrotomy?
If a stone can’t be pushed back
Why perform a urethrostomy?
Recurrent or persistent urethral obstruction
If you perform a urethrostomy, what must you do?
Neuter
For a perineal urethrostomy (cat), what level must be reached?
Bulbourethral gland
What does a urethrostomy not cure in male cats?
FIC!!
What 2 groups of dogs are most likely to have a urethral prolapse?
Brachycephalic dogs (English Bulldogs)
Intact males
What is a strong recommendation for a dog that has a persistent urethral prolapse?
Neuter
If a patient receives a urethropexy, what is an important complication that needs to be reduced?
Need to keep patient calm (ace and butorphanol) and can’t breed for 4-6 weeks
What percent of malignancies in dogs are attributed to bladder cancer?
2%
What is the most common bladder cancer in dogs and cats?
Transitional cell carcinoma
aka urothelial carcinoma
How do urinary tumor patients normally present?
With lower urinary tract signs - hematuria, stranguria, pollakiuria, dysuria
What is the most common area of the bladder to develop a tumor?
Trigone!
What are the 4 treatments for urinary tumors?
Surgery
NSAIDs
Radiation
Chemotherapy
What is an important thing to remember when performing neoplasia surgery in the bladder?
Potential for “seeding”
What is an NSAID that has been proven to work against urinary tumors?
Piroxicam (Feldene)
What are the 3 things that piroxicam does to decrease cancer
Induction of apoptosis of cancer cells
Inhibition of angiogenesis
Reduction in cell proliferation
What are the 2 other NSAIDs that are COX-2 inhibitors that have been shown to be as good as piroxicam?
Deracoxib and firocoxib
What is the chemotherapy drug that has the best response rate to urinary tumors?
Vinblastine
What was said to be the best option for treating neoplasia of the bladder?
Combination of chemotherapy and NSAID (piroxicam and miloxantrone)
What infection is higher in patients with urinary cancers?
UTI
What are the 2 most common isolates from urinary cancer UTIs?
E. coli and staph
What is a successful way to relieve an obstruction produced from the urinary neoplasia?
Urethral stent
This is a salvage procedure
Are urinary cancers usually treatable?
Usually no
What is the most common kidney neoplasia in young dogs?
Nephroblastoma
What is the renal tumor caused by a missense mutation in German Shepherds?
Renal cystadenocarcinoma
What is the most common renal cancer in cats?
Renal lymphoma
How is renal lymphoma most often treated?
Chemotherapy
What is the typical medical protocol for spays?
Opioid and sedative IM
Induction IV
Inhalant
NSAID
What drug is Zorbium
Buprenorphine - Partial mu agonist
How long does Zorbium take to take effect?
1-2 hours
How long does zorbium act for?
4 days
What is a good drug protocol for pig spays?
TKX + morphine
What do you need to be aggressive with during mastectomies?
Pain management, they are very painful!
What can be done post op to help with the pain from mastectomies?
Full mu, CRI of ket or fentanyl
What is high during a uroabdomen/
BUN, creatinine, potassium
Dehydration and metabolic acidosis
What drug is specifically good for goats undergoing cystotomies?
Benzodiazepines
If the procedure is especially painful, what should be considered?
a CRI
What are the 2 most common signalments for cows that have pyelonephritis?
Females
Less than 90 days post calving
What are the 3 risk factors for ruminants toward pyelonephritis?
Dystocia
Abortion
Post-partum infections
What is the primary agent in ruminants to cause pyelonephritis?
Corynebacterium renale
What are the 3 laboratory findings for pyelonephritis?
Leukocytosis
Hyperfibrinogenemia
Hyperglobulinemia
What are the 3 things that should be done for treatment of pyelonephritis?
Antibiotics - aggressive and long term
Diuresis - rehydrate and remove debris. Replace protein loss
Nephrectomy
Which antibiotic is best used for treatment of the pyelonephritis?
Penicillin
Should you continue to treat if it is bilateral pyelonephritis?
No!
Which flank should you approach the kidney from?
Either
What is the cause of amyloidosis?
Chronic inflammation
What is the treatment for amyloidosis?
There isnt one
What is possible after a nephrectomy for pyelonephritis?
Transient post-operative worsening of renal enzymes
What 2 species are the most common to have urolithiasis?
Goats and sheep
What is the main predisposing factor for a blockage?
Early castration
Testosterone on urethral diamteter
What is the most common type of stone in Ohio?
Struvite
What type of diet causes phosphorus based stones?
Grains
What type of diet causes calcium based stones?
Legumes
Which type of stone can you not see on radiographs?
Struvite
What is a risk factor for producing struvite stones/
Alkaline pH
What may be heard in severe blockage cases?
Arrhythmias
What drug group do you not want to give to blocked goats?
Alpha 2s - diuretic!
What position should you sit the blocked goat in?
On their rump
What type of stones can you seen on radiographs (3)
Calcium oxalate
Calcium carbonate
Silicate
What 3 markers do you expect to see on a blocked goat?
Creatinine
BUN
Potassium
What 3 things can you provide for medical management?
Ammonium chloride (will disolve struvite stones)
Acepromazine - muscle relaxer
Salt block to increase thirst
What are 4 decent options for pain management?
Morphine
Torb
Banamine
Meloxicam
What are 2 fluid options in blocked goats?
Calcium gluconate - cardioprotectant
Dextrose
What else can be provided to reduce concern of cystitis?
Penicillin or Naxcel (ceftiofur)
What are the steps to a urethral amputation?
Premed with midazolam and ketamine
Proceed with an angled cut
What is an option for stabilization until referral?
PTC or percutaneous tube cystotomy
What are 4 complications with PTCs?
Loss of bladder distention
Inadvertent gastrointestinal perforation
Balloon or tube malfunction
Security
What are the complications with perineal urethrostomy?
Urine scald
UTI
Stricture
Hemorrhage
What is a perineal urethrostomy?
They incise the urethra in the perineal area and pull it out as the new pee pee hole
What are 4 ways to prevent blocking goats?
Delayed castration
Increased water intake
Diet modification
Periodic dissolution
When should the umbilical stalk be dry by?
3-4 days
When should th umbilical stump fall off?
3-4 weeks
What should the umbilicus be treated with immediately after birth?
Either 7% iodine or 4% chlorhexidine
What is an external umbilical infection called?
Omphalitis
What is a urachal infection called?
Urachal abscess
What is an umbilical vein infection called?
Omphalophlebitis
What is an umbilical artery infection called?
Omphaloarteritis
What is the most common type of umbilical infection?
Omphalitis
What is the least common type of umbilical infection?
Omphaloarteritis
How do you treat an external abscess?
Lance it
Antibiotics (for 5-10 days) with cold hose therapy and some NSAIDS for pain
How far do you remove of the urachus?
All the way to the bladder apex
What clinical signs will a really sick obstructed patient present with?
Bradycardia
Hypotensive
Hypothermic
What is the largest concern for a really sick, blocked cat?
Hyperkalemia
What do you do to reduce the risk of cardio issues?
give calcium gluconate is bradycardia, hyperthermic, and hypotensive
How long does calcium gluconate last?
Only last 20-30 minutes
What should a patient be on before giving the calcium gluconate?
ECG
what is given after the calcium gluconate to actually reduce the blood potassium?
Insulin
What does the insulin do?
Opens the Na/K ATPase which moves the potassium intracellular
Why is calcium gluconate given before insulin?
It takes 15-30 minutes for insulin to take effect
What needs to be given in conjunction with insulin?
Dextrose
How does dextrose also help by itself?
The dextrose allows for endogenous insulin release
What is another thing you can use beside insulin to drive potassium into the cell?
Terbutaline
What is the mechanism for terbutaline?
B2 agonist
What are adverse side effects of terbutaline?
B2 spill over - tachycardia
B2 mediated vasodilation
What is another thing you can use beside terbutaline and insulin?
Sodium bicarbonate
What is the mechanism of action of sodium bicarbonate?
H/K antiporter
What does sodium bicarbonate also help to do?
Helps reduce metabolic acidosis
What are some adverse effects of sodium bicarbonate?
Decreased inionized calcium
Usually not required if appropriate fluid therapy is done. Alkalemia as bad if not worse than the academia if overshot
What is the next step after figuring out hyperkalemia?
Giving IV fluids
What does providing IV fluids help with?
Resolve azotemia, acidosis, hyperkalemia, dehydration, and hypovolemia
What does decompression provide for blocked cats?
Cystocentesis leading to immediate decompression and stabilization before catheterization
What should be used for the cystocentesis?
A 3 way stock cock
What should be done if when passing a urinary catheter, the cat is vocalizing or moving?
Give more drugs!
What mix of drugs should you not provide when catheterizing cat?
Full mu + benzo
Opioid + alphax + benzo
What do you hydropulsion with?
Saline lubricant
What catheter do you use for the urinary catheter?
Open tipped catheter (tomcat, slippery sam, or mila) - mila seems to be best
After passing a catheter and decompression, what is next?
Empty the bladder then flush with saline
Finally, suture the catheter in place and attach a sterile collection system
What do you do if you can’t pass a catheter?
Intermittent cystocentesis until surgery can be performed
How does uroabdomen present?
Severe azotemic, hyperkalemic, and acidotic
Does uroabdomen constitute a surgical emergency?
NO!
What should be done after uroabdomen patient is stabilized?
Given a urinary catheter
Keep bladder/abdomen empty
How long does a bladder defect take to heal?
3-5 days
Small tears may be conservatively managed but large tears will need surgery
Can bacteria be in urine without an infect?
Yes
Is urine naturally sterile?
No
What are 2 causes of bacteria in urine that aren’t UTIs?
FIC
Asymptomatic bacteriuria
What are the 2 groups that are most likely to get a UTI?
Spayed female dogs and cats over 10 years
Also incontinent animals and animals with urine retention
What are the 2 goals to therapeutic success of treating a UTI?
Eradication of infection
Avoidance of resistance to antibiotics
What are the 2 forms of acquired resistance?
Random DNA mutation
Plasmid transfer of DNA by transduction or conjugation
What percent of female dogs have subclinical bacteriuria
8.9%
There is a poor correlation between a UA and culture results. Lost of false positives
What are good antibiotics for UTI?
Amoxicillin or sulfas
What does MIC stand for?
Minimum inhibitory concentration
What does MPC stand for?
Mutant prevention concentration
How long must a patient be on a antibiotic
An adequate time above MIC
Most important thing is that T>MIC
Which antibiotics are more time reliant and need dosed more often?
B-lactams, cephalosporins, and macrolides
Which antibiotics are concentration dependent?
Fluroquinolones and aminoglycosides
If you have a recurrent or resistant UTI, what should your diagnostic approach be?
Culture
Find where infection is hiding
Can you use cranberry extract to help prevent UTIs?
Do not use in patients that create calcium oxalate stones!!
Is D-mannose ok?
Not recommended but safe
Is methenamine ok?
Transforms to formaldehyde in acidic urine
What type of dogs does the urethral sphincter mechanism incompetence occur in?
Spayed female dogs
What can be used for medical management of urethral sphincter mechanism incompetence?
Alpha agonists
Estrogen compounds
What is an alpha agonist that can be used for urethral sphincter mechanism incompetence?
Phenylpropanolamine (proin)
What are 3 side effects of proin?
Hypertension
Change in behavior
Change in appetite
There is an extended release proin but it isnt labeled for dogs under 10lbs
What are estrogen compounds that can be used to treat urethral sphincter mechanism incompetence?
DES
Estriol
What are the side effects of DES and estradiol?
Vulvar and mammary swelling
Attractiveness to male dogs
What are 2 surgical approaches to urethral sphincter mechanism incompetence
Artificial urethral sphincter
Injection of GAX collagen
What causes overactive bladders?
Low compliance of the detrusor muscle
What is the treatment for overactive bladders?
Anticholinergic drugs
What are the 3 anticholinergics that can treat low compliance?
Oxybutynin
Imipramine
Dicyclomine
What is FOO
functional outflow obstruction
Bladder contracts but urethra fails to relax
What is a strategy in males that suffer from FOO?
Neuter
What is a medical treatment for functional outflow obstruction (FOO)?
Alpha antagonist
What alpha antagonist can work to cure FOO?
Prozasin
Tamsulosin
Phenoxybenzamine
What is another option medically treating FOO?
Acepromazine, diazepam, anti-anxiety (trazodone/fluoxitine)
What is a good way to follow up and monitor FOO?
Measure residual volume
May also need to teach owner how to catheterize their dog
What is DUD?
Detrusor-urethral dyssynergia
Sphincter will contract after flow is initiated, leaving a large amount of residual urine
How to treat DUD?
Reducing smooth and striated muscle tone and reducing anxiety
What is the treatment for functional obstruction dysautonomia?
Bethanechol
Where is the lesion in automatic UMN bladder?
cranial to S1-S2
Where is the lesion in automatic LMN bladder?
At S1-S2
What is critical in an automatic LMN bladder?
Bladder is fully expressed and emptied
What sort of diet are PLN patients put on?
Protein and phosphate restricted diets
Do PLN only patients need the phosphate restriction?
No!
What is a supplement that can be given to protect kidneys in PLN patients?
Omega 3
What 2 things do omega 3s do to benefit PLN patients?
Reno protective
Suppress inflammation
If the kidney diet is already supplemented with omega 3s, do you need to supplement more?
No
What happens when RAAS is activated?
This is due to low flow within the kidney so the efferent arterial constricts to maintain GFR
What happens with chronic RAAS activation?
Endothelial damage that causes proteinuria and inflammation
What are the 3 drugs that block RAAS?
Angiotensin converting enzyme inhibitor (ACEi)
Angiotensin receptor blockers (ARB)
Aldosterone antagonist
With the use of ACE inhibitors and the decrease of GFR, what do you expect to see as a result?
Azotemia
What is better between ACEi and angiotensin receptor blockers?
ARBs
What ARB drug is on the market?
Telmisartan
Since aldosterone triggers the kidney to excrete potassium, what do you expect to see with ACEi and ARB?
An increase in serum potassium (hyperkalemia)
What are 2 commercial ACE inhibitors?
Enalapril
Benazepril
What should be checked 2 weeks after starting these medications?
Blood pressure
Chemistry panel (azotemia and potassium)
What protein is lost in proteinuria?
Albumin
What happens with hypoalbuminemia?
Differences in oncotic pressure that allows plasma water to leak into the abdomen (ascites)
What side effect do you need to be hyperaware of while using a diuretic and an ACEi/ARB?
Dehydration causing serious kidney damage
The RAAS slow down the GFR so that more fluid can be filtered but the diuretics increase the amount being filtered out so both combined are additive causing a lot of fluid loss
What is the mechanism of action of furosemide?
NaKCl pump blocker in loop of Henle
What are the 2 diuretic options/
Furosemide
Spironolactone
What is something that furosemide can cause?
Loss of potassium
What is the mechanism of action of spironolactone?
Aldosterone antagonist
What is a concern for spironolactone?
It is potassiums sparing
Patients that are on an ACEi or an ARB that may already be hyperkalemic may have issues here
What is often paired with RAAS inhibitor drugs to control hypertension?
Amlodipine
(hydralazine is another)
What is the mechanism of action of amlodipine?
Ca channel blocker
Typically, if the hypertension isn’t that high, you can start with just using a RAAS inhibitor but if this isnt the case, you will need to switch to using both RAAS inhibitor and amlodipine (or even more)
What immunosuppressive drug does she like for PLN?
Mycophenolate
What is an issue with PLN to do with clotting?
Decreased clotting time due to loss of antithrombin III
What is the most effective treatment of AKI?
Careful fluid management
What 2 phases are treatment most successful in AKI?
Induction and extension phases
what is the average fluid loss per day in dogs?
22 mL/kg/day
What is the primary sensible fluid loss?
Urine
What is an amount less than needed to excrete was products?
Oliguria ( <0.5 mL/kg/hr)
What is the normal need to execute products?
Nonoliguria (0.5-2.0)
What is maintenance fluid therapy?
66mL/kg/day