Block 1 (not including stuff from quiz 1) Flashcards
What substance secreted by H. pylori allows
it to cause infection in
the low pH stomach environment?
Urease (this converts urea to ammonia)
The innate response to
viral infection occurs
by which type of cells?
Natural Killer cells (aka null cells), have no lag period and its not antigen specific
During development, T
cells mature in the ____
whereas B cells mature
in the ____.
The thymus (Tcells)
Bone marrow (Bcells)
B cells do not secrete
antibodies until they
are converted to what?
into plasma cells
NK cell markers include
which two? What is the
function of each?
CD56 (does immune surveillance against tumor cells)
CD16 (ADCC Antibody-dependent cellular cytotoxicity, for NK cells)
What type of cells
proliferate, differentiate, and mature in germinal centers of lymph
nodes?
B-cells (which produce antibodies through the class-switch recombination, somatic hypermutation (a type of antibody), and then some affinity maturation (specific antibody)
ow many types of antibodies are there? In
what order do they mature?
GAMED
In order its: M, G, D, A, E
Elevated IgM signifies
what type of infection?
IgG?
It signifies acute; chronic (or convalescence/recovery)
Lack of mature B cells
leading to immunodeficiency is called…
Brutton’s x-linked ammaglobulinemia,
It usually presents between 6months-to-10yrs of age
It’s due to a genetic defect for B-tyrosine-kinase signaling
Which interleukin is the
b-cell growth factor?
Which is the b-cell differentiation factor?
interleukin 4 & 5, (these are secreted by CD4 cells and act as a master switch/control)
define paratope v. epitope
Epitope is the antigenic determinant that fits like a lock and key to the paratope on the Fab region of the B-cell which then can match with the antigen.
