Bipolar Disorders Flashcards

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1
Q

What are Bipolar Disorders characterised by?

A

Manic/hypomanic episodes and depressive episodes.

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2
Q

What does the name Bipolar mean?

A
Bi = two; 
Polar = opposite ends of the mood spectrum.
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3
Q

What kind of condition is Bipolar Disorder?

A

It is a chronic, episodic condition. It requires lifelong management.

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4
Q

What are the main (broad) issues that Bipolar Disorder is associated with?

A

Functional impairment;
suicide risk;
psychiatric and medical comorbidities.

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5
Q

What are three phases of illness/treatment for Bipolar Disorder?

A

Acute Stabilisation, ongoing maintenance, relapse prevention.

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6
Q

Treatment will differ throughout the course of the illness, based on what?

A

Based on the phase, severity and polarity.

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7
Q

What does treating Bipolar Disorder based on the polarity of the episode mean?

A

Which extreme side of the spectrum someone’s mood is (high vs. low).

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8
Q

In the DSM-5, what is criterion A. for a manic/hypomanic episode?
(two points)

A
  • abnormally & persistently elevated, expansive or irritable mood, and
  • increased goal directed activity/energy, present nearly every day.
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9
Q

According to the DSM-5, what is the difference in duration between a manic and hypomanic episode?

A

Manic - at least one week (or any duration if hospitalisation is needed).
Hypomanic - at least 4 consecutive days.

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10
Q

What are the 7 points for Criterion B. in the DSM-5’s definition of Bipolar? (for both Bipolar 1 & 2).

A
  1. inflated self-esteem or grandiosity.
  2. decreased need for sleep.
  3. rapid or pressured speech.
  4. flight of ideas or racing thoughts.
  5. distractibility.
  6. increase in goal-directed activity or psychomotor agitation.
  7. excessive involvement in risky activities (that will likely have negative consequences).
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11
Q

Of the 7 points for Criterion B. of Bipolar Disorder, how many are necessary for diagnosis? And to what extent?

A

At least 3 or more (4 if person is just irritable).

Significant presence in person that is noticeably different from usual behaviour.

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12
Q

Give an example of what the beginnings of a manic episode might look like?

A

Start by having a brilliant idea at work - something ground-breaking.
Focus intensely on idea, there is new-found efficiency, work is high quality, easier to complete.
Increased energy, drive toward goals.

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13
Q

What might someone in a manic state be oriented toward?

A

Pleasure seeking, such as buying things, sex, risky behaviour. Can’t see the negative consequences of behaviour.

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14
Q

What behaviour does the energy of a manic episode often produce?

A

Excessive exercise.

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15
Q

How might someone describe what they look like when they are in a manic episode?

A

They look brighter, sharper, more excited; ‘you can see it in their eyes’.

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16
Q

What are some negative experiences/emotions of a manic episode?

A

Can be traumatic, go into psychosis, feel paranoid, see connections between things, connections everywhere.
Still feels exciting but it is terrifying.

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17
Q

Which ‘episodes’ are necessary for a Bipolar 1 diagnosis?

A

Manic - necessary.
Hypomanic - NOT necessary (but can be present).
Depressive - NOT necessary (but can be present).
Typically B1 has both depressive and manic episodes.

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18
Q

Which ‘episodes’ are necessary for a Bipolar 2 diagnosis?

A

Manic - NOT necessary.
Hypomanic - necessary.
Depressive - necessary.

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19
Q

In Bipolar 1, what is the average ratio of manic to depressive episodes?

A

1:3 - depression occurs 3 times more than mania.

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20
Q

While Bipolar 1 has been present in literature for centuries (‘unexplainable joy and sorrow at the same time’), in which century was it that the illness was first classified?

A

18th century.

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21
Q

In Bipolar 1, what are the manic and depressive episodes deviations from?

A

They are deviations from wellness.

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22
Q

In Bipolar 1, what are ‘period’s of wellness’ considered to be?

A

Period’s of wellness are considered ‘remissions’.

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23
Q

When is the typical onset of Bipolar 1? Does it differ from time of diagnosis?

A

Early adulthood. Diagnosis isn’t always made at this time because the first manic episode may not be until much later.

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24
Q

Diagnosis of Bipolar 1 is normally made when mania is severe enough to - what?

A
  • disrupt social life and work.
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25
Q

At the severe end (top of the curve) of mania, what can it delve into?

A

Psychosis - hallucinations, paranoia, catatonia, jumbled thoughts.

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26
Q

Why is it important to quickly medicate severe mania, particularly if there are psychotic symptoms??

A

Because being in psychosis and severe mania can have an impact on the brain.

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27
Q

How do hypomanic episodes differ from manic episodes? (3)

A

Hypomanic episodes are less severe than manic episodes, shorter in duration and not severe enough to result in hospitalisation.

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28
Q

Although hypomanic episodes differ from manic episodes, why are they still important?

A

Because the changes in functioning, and mood disturbances, are uncharacteristic of the individual and noticeable to others.
Hypomanic episodes do not DISRUPT functioning but can still impair functioning.

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29
Q

What is a basic description of Cyclothymic Disorder?

A

A more chronic, less severe form of Bipolar Disorder (sub-threshold condition).

30
Q

What are the presenting symptoms of Cyclothymic Disorder?

And what must they cause to be considered an illness?

A

Numerous cycles of hypomanic and depressive symptoms (that are not severe enough to be classified as manic or major depressive episodes).
The cycling must cause distress or impairment in functioning.

31
Q

How long must the symptoms of Cyclothymic Disorder present for it to be diagnosed?

A

At least 2 years, with no more than 2 months without symptoms.

32
Q

How well can an individual with Cyclothymic Disorder function?

A

Some individuals function fairly well, but to be diagnosed there must be some impairment in functioning.

33
Q

What three elements of a Bipolar Disorder needs to be taken into account when considering treatment? (i.e. treatment depends on ___, ___ & ___.)

A

Treatment depends on the ‘phase of the illness’, ‘severity’, and ‘polarity’.

34
Q

In Bipolar treatment, what is ‘Acute Stabilisation’?

A

Treating someone in the acute stage of an episode (a peak in a deviation from wellness - either acutely manic or depressive).

35
Q

The treatments for all Bipolar Disorders are extrapolated from which type of Bipolar?

A

Bipolar 1.

36
Q

Even though there are strict guidelines for treating Bipolar, what must clinicians take into account?

A

That they must treat symptoms as they come and not necessarily exactly what the guidebooks say.

37
Q

What is the best overall treatment of the Bipolar Disorders?

A

Pharmacological treatments with adjunct psychological interventions.

38
Q

What is the goal in Acute Stabilisation of a manic episode?

A

Goal is to reduce arousal, agitation, aggression, cognitive/behavioural disturbances and psychosis (if present).

39
Q

In Australia, what does mental health legislation allow?

A

Involuntary admittance to hospital.

40
Q

What is the first line of treatment in the acute stabilisation of mania?

A

Pharmacotherapy.

41
Q

In Acute Stabilisation, list the (potential combination of) drugs needed for: the stabilisation of manic mood;
the rapid containment of behavioural disturbance;
the management of cognitive disturbance.

A
  • Stabilisation of manic mood:
    mood stabiliser, antipsychotic.
  • Containment of behavioural disturbance:
    antipsychotic, short-term benzodiazepine.
  • Management of cognitive disturbance:
    antipsychotic.
42
Q

How does pharmacological treatment of Hypomania differ from the treatment of Mania?

A

It follows the same principles in treating mania, but needs less intense doses of medication (or sometimes just psychological treatment).

43
Q

What is the goal in Acute Stabilisation of a Depressive episode?

A

To achieve complete remission of depressive symptoms, to reduce suicide risk, to return to wellness and function normally again.

44
Q

Patients spend most of their time in sub-clinical or clinical depression, why is it necessary to treat this polarity?

A

Because depression is often the most disabling part of Bipolar.

45
Q

Pharmacotherapy is the most effective way to treat a severe depressive episode in Bipolar, what are the two types of therapy and what do they involve?

A

Monotherapy - treatment with one medication (either anti-psychotic or mood-stabiliser).
Combination therapy - treatment with either anti-psychotic/mood-stabiliser WITH an antidepressant (adjunct).

46
Q

What risk is involved when introducing an antidepressant to a patient experiencing a Depressive episode? (name the term)

A

‘Treatment emergent affective switch’, whereby the antidepressant triggers the onset of a (hypo)manic episode

47
Q

When treating someone who is experiencing a Depressive episode with an antidepressant, what must a clinician do?

A

They must be closely monitored by a psychiatrist.

48
Q

What is the third line of treatment for acute mania, and/or severe (treatment resistant) depression? (in the Acute Stabilisation phase of treatment).

A

Electroconvulsive Therapy (ECT)

49
Q

What is the procedure of ECT like for a patient?

A

It is a controlled and safe procedure. It is normally conducted by a psychiatrist, can be out-patient or in-patient. An electro-current pulses through the brain (for 20 seconds) and the entire procedure is over in 20 minutes (under anaesthesia). The response is quick and lasting.

50
Q

What are some short-term effects of ECT and why do they not matter too much?

A

Short-term effects: confusion, disorientation, memory loss. But the benefits out weigh these effects.

51
Q

What is the focus of Ongoing Maintenance in the treatment of Bipolar?

A

Prolonging periods of wellness.

52
Q

What type of medication is used in the Ongoing Maintenance phase of Bipolar treatment?

A

Prophylactic medication (preventative).

53
Q

During the Ongoing Maintenance phase of Bipolar treatment, what type of meaningful input can take place?

A

Psychological input.

54
Q

What are the three main aspects of overall Ongoing Maintenance treatment?

A

Medical, psychological and social/lifestyle.

55
Q

What four types of drugs are used in the Ongoing Maintenance phase of Bipolar treatment?

A

Mood stabilisers, anticonvulsants, antipsychotics, antidepressants.
(Antidepressant’s must be used as an adjunct).

56
Q

In the Ongoing Maintenance of Bipolar treatment, what must be closely monitored?

A

Medication - must review tolerability and efficacy, then closely monitored for side effects. Everyone responds differently.

57
Q

What are short-term side effects and long-term side effects of Bipolar pharmacotherapy?

A

Short-term: weight gain, drowsiness, dizziness, stomach upset, dry mouth, constipation.
Long-term: kidney, renal, thyroid and cardiac functioning.

58
Q

What is the oldest drug therapy of Bipolar? The one that was specifically developed for the disorder. What is it?

A

Lithium. A naturally occurring element.

59
Q

How common is Lithium in the treatment of Bipolar?

A

It is the first-line pharmacotherapy treatment across international guidelines.

60
Q

What episodes of Bipolar does Lithium treat?

A

Both manic and depressive episodes.

61
Q

What has newer research of Lithium found?

A

It has neuro-protective and anti-suicidal properties (countries with higher levels of Lithium in the water).

62
Q

What are some considerations of Lithium (considering it is a natural element)?

A

Concentrations of Lithium that are too high can be toxic.

63
Q

What is the ‘narrow therapeutic index’?

A

In something like Lithium, need to make sure the concentration is not so low that there is no effect, but not too high that it becomes toxic.

64
Q

What are the four types of psychological therapies used to treat Bipolar Disorders?

A
  1. CBT
  2. Interpersonal and Social Rhythms Therapy
  3. Psychoeducation
  4. Family-focused therapy.
65
Q

CBT is considered the best therapy for the treatment of Bipolar, what does it involve? (4ish things)

A

Mainly Cognitive Restructuring:

  • change emotional experience by changing thoughts.
  • learn how to monitor symptoms.
  • challenge unhelpful thinking.
  • improve medication compliance and self-efficacy.
66
Q

What does Mindfulness-Based Cognitive Therapy aim to do?

A

Teach people how to become aware of thoughts and feelings, to relate to them as ‘mental events’, rather than as aspects of self/reflection of reality.

67
Q

What is psychoeducation?

A

In the case of Bipolar Disorder, psychoeducation manuals are developed to become highly intensive treatment that help educate the patient about symptoms.

68
Q

What is Family-Focused therapy? Why is it important?

A

The whole family is treated to help improve communication and understanding of when the patient might relapse. This therapy is based on evidence that family stress moderates relapse.

69
Q

What does Relapse Prevention involve?

A

Daily mood monitoring & developing relapse prevention plans.

70
Q

What does a Relapse Prevention Plan involve?

A

Identifies support team (doctors, family members), write down specific warning signs, plan of action. Be specific in what people need to do, even sign that they should be admitted to hospital.

71
Q

What is key for the overall coordinated care of a patient?

A

Psychoeducation for all involved and developing a relapse prevention plan.