Bipolar Disorder Flashcards

1
Q

Manic Episode

A

Distinct period of abnormally and persistently elevated, expansive, or irritable mood and persistently increased goal directed activity or energy, lasting at least one week. Three or more of (for or more if mood is irritable) and represents a change from unusual behavior:

2 exceptions for one week time frame:
Psychotic as a result of manic sx
Hospitalized for mania

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2
Q

Manic Episode Symptoms

A

Inflated self esteem or grandiosity
Decreased need for sleep
More talkative than usual or pressure to keep talking
Flight of ideas or racing thoughts
Distractibility
Increase in goal oriented activity
Excess involvement in activities that have a high potential for painful consequences (ex overspending, inappropriate sexual advances, infidelity, hypersexuality, legal problems)

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3
Q

Hypomanic Episode

A

Can be part of bipolar I and II
Distinct period of abnormally and persistently elevated, expansive, or irritable mood lasting at least 4 days and three or more or manic symptoms required (for if mood is irritable)
Unequivocal change in functioning
Observable by others
Not severe enough to cause marked impairment
No psychosis or hospitalization

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4
Q

Bipolar I

A

Manic episodes (usually includes both manic and depressed)

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5
Q

Bipolar II

A

Depressed episodes + hypomanic episodes

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6
Q

Cyclothymia

A

Patients do not get manic get hypomanic

Do not get depressed get dysthymic

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7
Q

35 year old F reporting sx of a depressed episode. You ask how she was doing before. She reports feeling quite good for 5 days. She did not require as much sleep and was feeling very goal directed. She went though boxes from a recent move. Prior to depressed episode she likely experienced?

A

Hypomanic episode

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8
Q

Disruptive mood Dysregulation Disorder

A

New diagnosis. Children with frequent temper tantrums. Bipolar like thing in children. Kids with cycling mood. Irritability, temper tantrums.

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9
Q

Cyclothymic disorder

A

Dysthymia +hypomania periods

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10
Q

Premenstrual dysphoric disorder

A

In the majority of menstrual cycles at least 5 sx starting the week before menses and ending after.

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11
Q

A 68 year old woman with hx depression brought in by police after she was found destroying her home with a sledgehammer and concerned neighbors called the police. She snaps at you and states “my smoke detectors would not stop beeping, what was I supposed to do?” For the last week, she has only been sleeping 2 hours at night, is distractible, talkative, and reports racing thoughts.

A

Manic episode.

Not hypomanic bc she is having dysfunction by ruining her house.

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12
Q

Course of Bipolar Disorder

A
Onset
19-29 years 
Episodes 
Manic episodes last 5-10 weeks 
Depressed episodes last 19 weeks 
Average number of episodes in a lifetime is 10 
Lifetime prevalence 
1-3%
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13
Q

Genetics

A

ID twins show 50-75% concordance for bipolar disorder

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14
Q

Treatment Planning

A

Practical and emotional support
Social considerations
Available caregivers, health facilities
For ambulatory/outpt treatment, combinations of medication and psychotherapy, and sleep hygiene is crucial

Hospitalize for psychosis, suicidality, continued self harm due to substances, inability to care for self, medical problems, legal problems

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15
Q

Treating Bipolar Disorder

A

Mood Stabilizers (some are anticonvulsants)
Lithium- gold standard. Works for depression, mania, and maintenance
Carbamazepine and valproate (works for mania and maintenance)
Lamotrigine (for bipolar depression and maintenance)
Atypical antipsychotics for mania/ mixed/ bipolar depression +/- psychosis
Stop antidepressants
Sleep hygiene/ benzos
Psychotherapy
ECT

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16
Q

Lithium toxicity

A

Anytime that you change your salt status you can get lithium toxicity. Any time you eat lots of salt, get dehydrated, hike, sweat, etc.
Diarrhea, neuro sx (tremor ataxia seizures confusion coma death)
Only way to get rid of it is to dialyze.

17
Q

Best way to treat acute bipolar depression

A

Not all mood stabilizers are created equal
Acute bipolar depression
Strongest evidence: olanzapine/fluoxetine, olanzapine, quetiapine, lurasidone, ECT
Modest evidence: lithium, valproate, lamotrigine
No evidence: antidepressants in general, the atypical antipsychotics (not mentioned above) or typical antipsychotics