BIOMED 3 Flashcards

Craniofacial development + cleft lip & palate

1
Q

What has developed by 4-5 weeks?

A

Pharyngeal apparatus
- 1st arch is now called mandibular arch
- 2nd arch is now called hyoid arch

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2
Q

What are 6 external changes that form in weeks 4-5, contributing to craniofacial development?

A

Frontonasal process
Maxillary process (arches)
Nasal placodes
Nasal pits
Mouth
Tongue

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3
Q

What does the frontonasal process grow from?

A

Ectomesenchymal cells (cranial neural crest cells left on top from neurulation) that migrate to region & start to form new growth

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4
Q

Why is the frontonasal process an important outgrowth?

A

Forms structures of the face

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5
Q

Where does the maxillary process (/maxillary arch) start to grow from?

A

Posterior of mandibular arch
Starts lateral, will move more medially

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6
Q

Why is the maxillary process an important outgrowth?

A

Forming the palate + bones of the face

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7
Q

How are the nasal placodes and nasal pits formed?

A

In the frontonasal processes, ectomesenchyme cells form nasal placodes (blue)
Nasal placodes invaginate backwards + medially to form nasal pits (red)

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8
Q

How is the mouth formed?

A

Buccopharyngeal membrane breaks down (green)

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9
Q

How and when is the tongue formed?

A

In week 4… tongue buds arise from dif pharyngeal arches (I II III IV)
Fully formed by week 12

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10
Q

What are 4 external changes that form in weeks 5-7, contributing to craniofacial development?

A

Mandible
Eye placodes
Medial nasal processes fuse
Maxillary process continues to grow

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11
Q

How is the mandible (lower jaw) formed?

A

Mandibular arches fuse

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12
Q

How do the eye placodes form?

A

From ectoderm tissues, gives rise to main structures of the eye

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13
Q

What happens when the nasal pits move more medially, closer together?

A

Medial sides fuse to form tissue called the intermaxillary process (IMP)

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14
Q

What does the intermaxillary process form?

A

Primary nasal septum
Primary palate
Philtrum

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15
Q

What is the primary nasal septum?

A

Tissue that remains between the 2 fused medial nasal processes

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16
Q

How can a deviated septum affect speech?

A

Can affect breathing/resonance of voice

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17
Q

What is the primary palate?

A

Formed from same tissue as primary nasal septum (IMP) but extends horizontally + posteriorly

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18
Q

What does our palate today derive from?

A

Fusion of primary + secondary palates

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19
Q

What happens at 5.5 and 6 weeks when the maxillary process continues to grow?

A

Fuses with lateral nasal process to form nasolacrimal groove (light blue)
Fuses with medial nasal process (red)
Fuses with mandible below (dark blue)

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20
Q

What are 2 external changes that form in weeks 7-8, contributing to craniofacial development?

A

Philtrum
Fusion of maxillary + mandibular process

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21
Q

What is the filtrum?

A

Vertical line formed where the medial nasal processes + maxillary processes meet

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22
Q

How does cleft lip occur?

A

Incomplete fusion of one/both medial nasal processes + maxillary processes
(thus can be uni/bilateral)

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23
Q

What is the term for the incomplete fusion between the maxillary + mandibular processes?

A

Macrostomia

24
Q

What is the term for the overcomplete fusion between the maxillary + mandibular processes?

A

Microstomia (small mouth)

25
Q

What is the internal changes that forms in weeks 7-8, contributing to craniofacial development?

A

Secondary palate (main palate)

26
Q

What is the secondary palate?

A

Roof of the mouth which separates the oral cavity from the nasal cavity

27
Q

What are the 2 parts of the secondary palate?

A

Anterior 2/3 = hard palate, bone
Posterior 1/3 = soft palate, muscles with roles in breathing + swallowing

28
Q

How is the secondary palate formed?

A

Outgrowth of maxilla bones: palatine processes /shelves (cartilage)
Horizontal plates of palatine bones move toward each other (posterior)

29
Q

How did the secondary palate take a horizontal position above the tongue?

A

Initially, palatine processes deflected downwards by developing tongue
Mandible widens, allowing tongue to drop into floor of mouth
Palatine processes now have no restraint: shelves elevate

30
Q

What fuses in regards to the secondary palate formation?

A

Palatine processes with…
- each other
- primary palate
- new secondary (bony) nasal septum

Maxillary tissue with mandibular tissue

31
Q

How does cleft palate occur?

A

growth defect in palatal shelves
Delay in shelf elevation → failed fusion of lateral palatine processes / nasal septum / median palatine processes

32
Q

What are 6 examples of cleft lips/palate?

33
Q

What are the impacts of an incomplete left lip?

A

Little, but parents may choose to have surgery for psychological reasons

34
Q

When is cleft lip/palate picked up?

A

In scans / first few days

35
Q

How can cleft lip/palate impact newborns before surgery?

A

Harder to build pressure for feeding

36
Q

Why does cleft lip have little impact on speech?

A

Repaired at 3-4m
Successful + easy surgery

37
Q

Why do children with cleft lip + palate have higher risk of speech difficulties?

A

Can’t have palate repaired until 9-12m, as have to have lip repaired first (as easier + needed for feeding)

38
Q

Do those with a bilateral cleft lip or a unilateral cleft lip have worse speech outcomes?

39
Q

What is a submucous cleft palate?

A

Palate may looks unaffected
But, muscles that lift soft palate for speech are abnormal/defected

40
Q

What are 4 signs of a submucous cleft palate?

A

Split uvula
Bony gap at back of hard palate
Midline of soft palate looks very thin / translucent
Nasal sounds

41
Q

How many babies in the UK are born with a cleft lip and/or palate?

42
Q

How many babies in the UK are born with a cleft palate only, and which gender does it occur more in?

A

1 in 2500 live births
Greater incidence in females

43
Q

How many babies in the UK are born with a cleft lip and palate, and which gender does it occur more in?

A

1 in 800 live births
2:1 male to female ratio

44
Q

Is there a known cause of clefts?

A

Largely unknown
Combination of genetic + environmental factors
Correlation, not causation

45
Q

What are 4 contributory factors towards clefts?

A

Heavy smoking in early stages of pregnancy
Heavy alcohol consumption in early stages of pregnancy
Folic acid deficiency in early stages of pregnancy
10% born with cleft also have associated genetic syndrome

46
Q

What are 4 genetic conditions linked to cleft?

A

Van Der Woude syndrome
Pierre Robin syndrome
Stickler’s syndrome
22q11 deletion syndrome

47
Q

What are 4 impacts of cleft / palatal formation probelms?

A

Feeding + swallowing
Speech
Language
Social + emotional + educational attainment

48
Q

What is velopharyngeal dysfunction (VPD) ?

A

Can occur after surgery
30% (potentially more)
Soft palate doesn’t completely close off the throat as it should during speech production
Palate too short / muscles weak

49
Q

How does velopharyngeal dysfunction (VPD) affect speech/swallowing?

A

Hypernasal, as struggles to make pressure for certain sounds
Dysphagia: goes up nose, risk of aspiration

50
Q

What is the impact of velopharyngeal dysfunction for people that speak other languages?

A

May sound more ‘normal’ if language uses more nasal sounds

51
Q

What are the 2 main ways in which consonant production is affected by cleft?

A

Structural defect: child cannot avoid losing air through nasal cavity, weak + nasalised consonants (can use tongue, but sounds backed)
Active strategy/compensation to prevent oral-nasal, so changes place/manner of articulation, continues with learnt speech errors even when palate repaired

52
Q

What are 4 common compensatory articulations (cleft speech characteristics)?

A

Glottal stops
Nasal fricatives
Pharyngeal fricatives
Velar stops

53
Q

What are glottal stops (common compensatory articulation)?

A

Pop of air when vocal folds forced together
- release of air can make it sound like consonant omitted

54
Q

What are nasal fricatives (common compensatory articulation)?

A

Stream of air directed through nasal cavity, not oral cavity
- sounds like talking through the nose

55
Q

What are pharyngeal fricatives (common compensatory articulation)?

A

Base of tongue pressed against back of throat
- raspy ‘h’ (unintelligible)

56
Q

What are velar stops (common compensatory articulation)?

A

Sounds made further back in mouth than intended