BIOM PART TWO - CUE CARDS

Question 1

What is POMC?

Answer 1

Proopiomelanocortin

Question 2

What are Convertases?

Answer 2

Enzymes that cleaves POMC

Question 3

What do different converses do?

Answer 3

Give rise to different products

Question 4

What does the melaocortin System consist of?

Answer 4

13 components from POMC

Question 5

What are the 4 Post-Translational peptides?

Answer 5

a-MSH, b-MSH, y-MSH, ACTH

Question 6

What are the 5 Melanocortin Receptors?

Answer 6

7-membrane. G-protein Coupled

MCR-1 —- MCR-5

Question 7

What are the 2 Melanocortin Antagonist?

Answer 7

AgRP (Agouti)

Question 8

What are two proteins that modulate Melanocortin Activity?

Answer 8

Mahogany, Syndecan-3

Question 9

What is the 1 Opiod Protein?

Answer 9

B-endorphin

Question 10

What is the Post-Translational Processing of POMC?

Answer 10

Tissue/cell specific

Question 11

How is it tissue specific?

Answer 11

Different POMC peptides will be produced by different cell types

Control of Range of physiological functions by the same prohormone

Question 12

What is a-MSH function when produced in brain

Answer 12

Inhibit food intake

Question 13

What is a-MSH function when produced in skin?

Answer 13

Acts on Melanocytes to produce skin pigmentation

Question 14

What are MCRs produced in?

Answer 14

Brain, Adrenals, Penis, Skin

Question 15

What is the a-MSH pathway?

Answer 15

1.) a-MSH binds to MCR-1

2.) G-protein coupled, Camp, PKA, CREB

3.) CREB synthesizes MITF

3.) MITF starts Txn of Tyr and DCT which results in skin pigmentation

Question 16

What are Agouti Mice?

Answer 16

A result of an overproduction of Agouti protein in the skin

Question 17

What is Agouti protein in the skin?

Answer 17

MCR1 Antagonist in the Skin (yellow mutation)

Question 18

What is Agouti Protein in the brain?

Answer 18

MCR4 Antagonist (obesity, hyperglycaemia, insulin resistance)