Biological Methods Flashcards
describe ct scans?
In CT scanning, an x-ray is used to get the picture along with a computer which creates detailed images, (in PET scanning it is a radioactive tracer, in MRI, magnetic imaging is used). A CT scan produces pictures in slices which can be looked at individually or can be put together to give a 3-dimensional view of the “whole” area, such as part of the body. The pictures are formed and pick up how the area being scanned reacts to the x-ray being passed through it, showing how far the x-ray is blocked. Knowing how areas block the x-ray shows something about the area, such as whether a tumour is present. In psychology CT scans can be used to understand damage to the brain.
The person lies inside a large doughnut shaped scanner and the scanner is slowly rotated around them. Images of the brain and/or body are taken from different angles. It can take a few minutes to 30 minutes.
Betts (2009) did a review of the use of scanning in defence of people pleading not guilty by reason of insanity (NGRI) in courts. She mentions the use of CT, PET, MRI and fMRI scanning to provide neurological data to support claims of NCRI. Betts argues that neurological evidence does not show that a mental deficit will stop someone from knowing that what they are doing is wrong and juries may be affected by scientific evidence from scanning that suggests a cause-and-effect relationship when there is not one.
She cites the case of Herbert Weinstein, a 64-year-old man who in 1991 strangled his wife after an argument. His defence was that a cyst had caused pressure on his prefrontal cortex, which had affected his understanding of right and wrong. There was CAT scan evidence of differences in his brain (widening suici) that related to those with schizophrenia. After a long argument, the evidence was admitted, and he was acquitted but admitted to a hospital.
strengths of ct scans?
- A CT scan is not painful at all and is non-invasive, which means there is no need to “enter” the body so is more psychologically ethical and may cause less distress than other methods of studying the brain, (although if a dye is used, that is not entirely the case).
- CT scanning use of X-rays which means that it is less harmful than PET scans when used in psychological research, which uses a radioactive tracer which could potentially ethically harm the patient if used to regularly.
2 weaknesses of ct scans
- CAT scans require more radiation than x-rays, the more detailed the scans the more the radiation, - to they cannot be used often in psychological research as they ethically could hard participants.
- CAT scans only provide structural information, unlike PET scans which give activity information, so they have a limited use in researching links between the brain are areas of behaviour like aggression.
describe pet scans
A PET scan is used to study the brain, it highlights “hot spot” areas in the brain (metabolic activity – areas most active) which tells us which parts of the brain are working at certain times. A computer generates images from the information and a radioactive tracer is added to oxygen or glucose – something that the body uses. As the tracer is used on the brain, this will show up as an area of activity. The tracer reaches the brain about 1 minute after being injected and takes 10-15 minutes to decay. As the tracer decays it releases minute amounts of radioactivity (initially in the forms of positions). The emission of radioactive particles is detected by the scanner and used to produce a record of the levels of activity in the brain tissue. This shows up as an image which can then be interpreted – the most active areas are coloured red or yellow and least active blue.
The participant is generally scanned several times in two conditions, condition one is a set of recordings taken when they are inactive, a baseline measures and condition two is another set of records taken when they are performing a task. The difference between the scans tells us which parts of the brain are involved in that activity. Language involves a number of brain areas because the individual has to find the word, prepare to speak it and then say it. By asking someone to think of words, real words, speak words and other such tasks, researchers can find which parts of the brain works for a particular language function.
PET scanning can show size of brain areas and they can then be measured and compared between people, for example, Raine et al used PET scanning to measure the prefrontal cortex levels of murders and non-murderers.
strengths of pet scans
- PET scans are functional and more useful to psychologists than structural scans because they allow us to visualise events that are actually happening in the brain ie, by asking someone to think of words and detecting which parts of the brain are working. Maguire (1997) used PET scans to show that the hippocampus was active during recall of journeys by taxi drivers. This adds to the validity of the PET scans as a method.
- PET scans have been used successfully to add depth to memory research, for example, Piolino et al (2005) asked participants to recall relatively recent memories and some from long ago; their PET scans revealed that although there was some overlap in the brain areas activated, the older memories also triggered activity in some different locations in the brain.
weaknesses of pet scans
- Scanners restrict movement so brain activity can only be studied in passive bodily states eg, listening or imagining, real action and moving around is limited so validity is not complete when applying to areas in psychology such as aggressive acts.
- Exposure to scanning may need to be limited because of exposure to radioactivity (tracer) which could cause health problems and is ethically not acceptable in many psychology studies.
describe mri scans
Uses radio ways to measure blood oxygen levels in the brain. Those area of the brain that are most active use most oxygen and therefore blood is directed to the active area – called haemodynamic response. The activity/response is picked up through radio signals and these signals produce a series of images of successive “slices” which hare hen turned into a 3D image by a computer.
Pardini et al used fMRI scans to measure the volume of participants amygdala’s and relate this to observe levels of aggression.
strengths of mri scans
- As with PET scans are accurate in checking for psychological abnormalities in the brain and the rest of the body, therefore there is validity because what is found by the scan is then often found in reality.
- Unlike PET scans which involves the use of a radioactive tracer, fMRI does not use radiation and so it is ethically a very safe method of studying the brain.
weaknesses of mri scans
- Scanners restrict movement so brain activity can only be studied in passive bodily state, so physical activity is not measured at all; this means that knowledge of psychology is limited to areas like soft tissue and body organs.
- MRI scanners are noisy so could be distressing and ethically can be stressful, especially for young children who might become very distressed.
describe one twin study
One twin study and one adoption study, e.g. Gottesman and Shields (1966); Ludeke et al. (2013).
Twin and adoption studies are used to study the influence of GENES on behaviour. Genes and DNA give the biological blueprint for each person’s development; they interact with the environment as the person grows.
Identical twins have identical genes; non-identical twins share 50% of their genes. By comparing identical and non-identical twins with regard to a certain characteristic, it can be seen what influence genes have. A problem is that twins share much of their environment as well as their gene, which is why adoption is important.
Adopted children are brought up in different families and do not share their environment with their biological family. Identical twins that are reared apart, not sharing the same environment but sharing the same genes, are important as participants as that too controls the effects of environment, to an extent at least.
Twin and adoption studies relate to the nature-nurture debate, which is about how far a characteristic comes from nature and how far it comes from nurture.
Nature is what we are born with and is controlled by our genes. Nurture is what we experience from the environment as we develop. Environment includes influence from parents, culture, interactions with others and all other experiences.
TWIN STUDIES
Identical (mz, monozygotic) twins share 100% of their genes because they come from one egg fertilised by one sperm. Studies with mz twins are slightly different from correlational studies because instead of comparing two variables from one person, the identical twins are compared with one another. Dizygotic (DZ) twins are non-identical which means that they come from 2 fertilised eggs (Di= two). Since they develop from different eggs, the DNA of DZ twins is only as similar as that of any siblings, it is not 100% the same, as it is in identical twins.
A concordance rate is established when a correlational statistical test is carried out comparing how one twin scores on a variable of interest compared with the other twin, for example, IQ is studied in this way. The IQ score from one identical twin can be set against the IQ score for the other identical twin; thus we can see whether one has a high IQ score when the other does too. If this is the case, there would seem to be grounds for saying that IQ is, at least to an extent, genetic in origin. Characteristics which are studied in this way include schizophrenia, IQ, alcoholism, depression, personality and anorexia.
describe strengths of a twin study
- twins provide a more valid comparison of shared genetic information than studies of siblings, as twins are the same age so are not subject to cohort effects so they are in effect their own control.
- twin studies suggest that genetic components may be involved in a wide range of psychological areas for example, Heterena et al (2003) found that MZ twins were more similar than DZ twins in their tendency to become classically conditioned to fearful stimuli as snakes and spiders.
- Twin studies have generated a large volume of data covering a wide variety of psychological variables for example Gottesman found a 48% concordance rate for MZ twins in relation to schizophrenia than 17% of DZ twins.
weaknesses of twin studies
- MZ twins look alike and so are likely to be treated in exactly the same way by other people, creating a more similar environment for MZ twins than DZ twins, therefore we do not know if it is due to genes (nature) or environment (nurture).
- As most people are not twins, the results from twin studies may not be representative or therefore generalisable to the entire population.
- In addition it is difficult to find large numbers of twins therefore sample sizes are likely to be small so again generalisability is limited.
describe brendgen study
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BRENDGEN ET AL.’S STUDY
APRC
Aim
To find out if there is a difference between physical and social aggression in 6-year-old school children by surveying their teachers and classmates. In particular, to see if physically aggressive children are also socially aggressive and to investigate whether the link is down to genetics or social situation by comparing MZ and DZ twins.
There are other studies into the origins of aggression. Bandura’s Bobo Doll studies look at how children learn aggression from the environment and Raine et al. look at how aggression is linked to brain deficits (but may have environmental explanations too)
IV
As a twin study, this looks for a correlation between (1) the aggression scores for identical (MZ) twins and (2) the aggression scores for non-identical (DZ) twins.
It also examines the correlation between (3) teacher ratings for the children’s aggression and (4) peer ratings from classmates for the children’s aggression.
As a natural experiment, it looks at the differences between (5) MZ and DZ twins and (6) girls and boys
DV
Teacher ratings for social and physical aggression were calculated out of 6 each; Peer ratings were taken from classmates who were asked to identify classmates from photographs who fitted various descriptions.
A main advantage of the present study is it assessed behavior not only by teachers but also by peers, who are rarely employed as a reporting source in twin studies - Mara Brendgen
The teacher overall scores for each child take the form of interval/ratio level data, but the children’s responses are frequencies for each child that take the form of nominal level data.
Sample
234 pairs of twins, taken from the Quebec Newborn Twin Study. This was a longitudinal study that was already going on and Brendgen used the data from it when the children were age 6.
There were 44 sets of identical (MZ) male twins, 50 sets of identical (MZ) female twins, 41 non-identical (DZ) males, 32 non-identical (DZ) females and 67 sets of non-identical (DZ) mixed-gender twins.
Because the sample was taken from another study, this should be considered a cluster sample.
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Procedure
The children had been entered into the Quebec Newborn Twin Study when they were born. They were assigned to MZ or DZ based on physical resemblance; 123 pairs of twins were DNA-tested and this backed up the assignment to MZ or DZ 94% of the time, which was considered reliable enough.
By age 6, 88 pairs of twins had dropped out of the study, but Brendgen obtained data on the remaining 234 twin pairs, got written consent from the parents and approached their schools. Because this was Quebec, some of the schools were English-speaking and some were French-speaking, so they surveys had to be translated and the researchers had to speak both languages.
The teachers’ questionnaires asked them to rate each child on a 3-point scale (0 = never, 1 = sometimes, 2 = often) on these 6 statements:
tries to make others dislike a child
says bad things or spreads nasty rumors about another child
becomes friends with another child for revenge
gets into fights
physically attacks others
hits, bites or kicks others
The scores for social aggression and physical aggression were added together to produce two overall scores.
For the peer ratings, the children were given a simpler task. They were shown photos of their classmates and asked to circle the photos of 3 children who best fit these 4 descriptions:
tells others not to play with a child
tells mean secrets about another child
gets into fights
hits, bites or kicks others
strenfths of brendgen study
- Adoption studies allow the identification of interesting relationships being linked to genetics and these can then be investigated further, eg, IQ, aggression etc.
- Adoption studies directly compare the influence of genes versus the environment so has good face validity because they isolate the influences of the environment due to the effects of the adoptive parents during the adopted individual’s childhood.
- Some studies can be longitudinal therefore they can be studied for differences over a longer period of time so more trends can be identified and extensive conclusions made on factors like IQ, aggression and schizophrenia.
weakness of brendgen study
- Selective placements mean that frequently people are placed with families very similar to their biological families, this makes untangling the influences of genes and environment very difficult.
- The samples are not representative, most people are not adopted, hence by definition people who are adopted are not representative of the whole population
- Families that adopt are similar to each other, so it may be something in that similarity of families who adopt that is causing the results, ie, specific types of family trait like more empathy or a need for financial reward.