Biochemistry Flashcards
Sensitivity
percentage of people with a disease with a positive test for that disease
Specificity
percentage of people without a disease who have a negative test for that disease
Prevalence
A measure of how common the disease is in the population of people who have been tested for the disease
People with disease + all the people who have been tested
Acidosis
increase H+ conc
Alkalosis
Decrease H+ conc
Respiratory component
pCO2
Metabolic component
HCO3-
Respiratory acidosis
Increase in H+ conc
Increase in pCO2
EG: choking, COPD
Respiratory alkalosis
Decrease in H+ conc
Decrease in pCO2
EG: PE, mechanical over-ventilation, anxiety, pain
Metabolic acidosis
Increase in H+ conc
Decrease in HCO3 (as it’s used up by the H+)
EG: over production of acid
Metabolic alkalosis
Decrease in H+ conc (loss of acid, alkali surplus)
Increase in HCO3
EG: vomiting (loose acid causing an increase in bicarbonate)
Compensation
Too much H+ , lungs blow off CO2 to restore ratio
Too much CO2, kidneys get rid of H+ to restore ratio.
If primary mechanism is resp then compensatory mechanism will be metabolic
Resp compensation for metabolic acidosis
Too much H+
Compensate by blowing off CO2.
Resp compensation occurs quickly
Metabolic compensation for resp acidosis
too much CO2
get rid of H+
Metabolic compensation occurs slowly
Fully compensated
pH is within normal ranges