biliary secretions and jaundice Flashcards
what is the role of the liver
detoxification of alcohol and drugs digestion of proteins fats and carbs production of bile 600-1200 ml per day production of ketone bodies glycogen storage vitb12, iron, vit D and A storage synthesis of plasma proteins
what is the function of bile
solubilisation of fats for absorption
neutralisation of stomach acid
route for metabolic excretion
what is bile made from and why is it good
made from bilirubin from break down of rbc
also made from excess cholesterol
where is bile synthesised and stored
synthesised in the liver and stored in the gall bladder
what is the pathway of bile from the liver to the duodenum
hepatocytes - cannaculi - bile duct - gal bladder - joins with pancreatic duct at ampulla then out via sphincter of oddi into duodenum
what is the the composition of bile
50% bile salts
40% phospholipids
4% cholesterol
2% bilirubin from breakdown of rbc
what does amphipathic mean
has both hydrophilic and hydrophobic elements
what part of bile is hydrophobic
top side nucleus and methyl group
what part of bile is hydrophilic
bottom part hydroxyl and carboxyl groups
why is it good that bile is amphipathic
allows solubilisation of fats with water
what does bilirubin do
colours faeces and bile
what happens to bile when it gets secreted it terms of primary and secondary form
bile is first secreted as 80% bile acid
in the colon it is transformed into a secondary bile acid (20%) where it ionises easily
it can bind to taurine and glycine where it becomes a bile salt
how is bile recycled
reabsorbed in the ileum and taken back to liver by hepatic portal vein
describe enterohepatic circulation
taurine and glycine enter enterocyte via na dependant transporter
hydrophobic bile acid enters passively
these bind together and are transported into hepatic blood via anion exchanger
uptake of conjugate into hepatocyte
atp transporter of them both back out
what ions are in the primary secretions of bile
ca
cl
k
na
