Beta Blockers

Question 1

beta blocker suffix

Answer 1

-lol

Question 2

receptors found in the heart

Answer 2

primarily beta 1

to a lesser extent beta 2

Question 3

beta 1 specific beta antagonists

Answer 3

metoprolol
acebutolol
alprenolol
atenolol
betaxolol
celiprolol
esmolol
nebivolol

Question 4

Non-specific beta blockers (no specificity for either beta 1 or beta 2)

Answer 4

propanolol
carteolol
penbutolol
pindolol
timolol

Question 5

beta 1 selective beta blocker with an extremely short half life

Answer 5

esmolol

Question 6

beta blockers with intrinsic sympathomimetic activity

Answer 6

pindolol
carteolol
acebutolol
labetalol
penbutolol

Question 7

3rd generation beta blocker with N.O. production and beta 2 receptor agonism

Answer 7

carteolol

Question 8

3rd generation beta blocker with alpha 1 receptor antagonism, Ca entry blockade, and antioxidant activity

Answer 8

carvedilol

Question 9

3 ways drugs can compensate for vasoconstrictive effects observed immediately after giving beta blocker therapy

Answer 9

alpha-1 receptor antagonism
Ca entry blockade
NO production

Question 10

In the membrane stabilizing activity of _____, _____, and _____, Na channels are bound and blocked.

Answer 10

propanolol
acebutolol
carvedilol

Question 11

Do beta blockers reduce BP in normotensive patients?

Answer 11

No

Question 12

Function of beta 1 receptors on juxtaglomerular A cells.

Answer 12

renin release

Question 13

Adverse CV effects of beta blockers.

Answer 13

CHF in pts relying on sympathetic activity to maintain cardiac output
bradycardia or bradyarrhythmias in patients with AV conduction defects
Cold extremities
ABRUPT DISCONTINUATION AFTER LONG-TERM TREATMENT CAN EXACERBATE ANGINA AND INCREASE RISK OF SUDDEN DEATH

Question 14

“Off target” pulmonary effects of beta blockers

Answer 14

blockade of beta 2 receptors on bronchial smooth muscle

Question 15

Beta blockers with moderate to high lipid solubility

Answer 15

penbutolol
propranolol
timolol
metoprolol
carvedilol
betaxolol

Question 16

“Off target” CNS effects of beta blockers

Answer 16

can cause mental disorders, fatigue and vivid dreams (usu. lipophilic drugs)

Question 17

“Off target” glucose effects of beta blockers

Answer 17

hypoglycemia (beta 2 receptors normally stimulate hepatic glycogenolysis and pancreatic glucagon release)
beta 1 blockers mask the tachycardia that serves as a warning sign for insulin-induced hypoglycemia

Question 18

“Off target” lipid profile effects of beta blockers

Answer 18

increase triglycerides
decrease plasma HDLs
(drugs with ISA or cardio-selectivity have less effect on tri and HDL)

Question 19

Symptoms of beta blocker toxicity

Answer 19

bradycardia
hypotension
arrhythmias
hypothermia
hypoglycemia
SEIZURES

Question 20

Primary clinical uses of beta blockers

Answer 20

HTN

Acute MI

Question 21

Non-CV applications of beta blockers

Answer 21

essential tremor
thyrotoxicosis
anxiety
prophylaxis of migrane headache
prevention of bleeding associated with esophageal varicies
treatment of glaucoma

Question 22

First generation beta-blockers (non-selective)

Answer 22

Nadolol
Penbutolol
Pindolol
Propranolol
Timolol

Question 23

Second generation beta-blockers (beta-1 selective)

Answer 23

Acebutolol
Atenolol
Bisoprolol
Esmolol
Metoprolol

Question 24

Third generation non-selective beta-blockers

Answer 24

Carteolol
Carvedilol
Labetalol

Question 25

Third generation beta-1 selective beta-blockers

Answer 25

Betaxolol

Nebivolol

Question 26

Beta-blockers with membrane stabilizing activity

Answer 26

pindolol
propranolol
acebutolol
metoprolol
carvedilol
labetalol
betaxalol