Alpha Blockers

Question 1

non-competitive, covalent (long-acting) alpha 1&2 antagonist

Answer 1

phenoxybenzamine

Question 2

short-acting, competitive antagonist at alpha 1&2 receptors

Answer 2

phentolamine

Question 3

clinical indications are pheochromocytoma & hypertensive emergency

Answer 3

phentolamine

Question 4

smaller doses of phentolamine have a greater effect on alpha __ receptors, which causes _____.

Answer 4

2; increased levels of NE -> increased BP

Question 5

what is an inotropic effect?

Answer 5

NO IDEA

Question 6

larger doses of phentolamine have a greater effect on alpha __ receptors, which causes _____.

Answer 6

1; vasodilation -> decreased BP

Question 7

phenoxybenzamine and phentolamine are not routinely used because

Answer 7

alpha 2 antagonists -> reflex tachycardia -> cardiac arrhythmias

Question 8

3 principal alpha blockers used to treat essential hypertension

Answer 8

doxazosin
terazosin
prazosin

Question 9

beta receptors _____ HR and _____ contractility.

Answer 9

increase; increase

Question 10

beta 2 receptors _____ skeletal muscle

Answer 10

relax

Question 11

alpha receptors _____ skin and splanchnic vessels

Answer 11

contract

Question 12

alpha 2 receptors are located ___-synaptically and function as ___-receptors.

Answer 12

pre; auto

Question 13

alpha 1 receptors are located ___-synaptically

Answer 13

post

Question 14

the channels that NE acts on

Answer 14

alpha 1 & 2

beta 1

Question 15

the channels that epi acts on

Answer 15

alpha 1 & 2

beta 1& 2

Question 16

the channels that isoproterenol acts on

Answer 16

beta 1 & 2

Question 17

first dose orthostatic hypotension seen with

Answer 17

alpha blockers

Question 18

alpha blockers that can be taken daily

Answer 18

doxazosin

terazosin