Beta-adrenergic agonists

Question 1

Non-selective Beta 1 ,Beta 2 -agonists

isoprenaline (isoproterenol)

Answer 1

sometimes is used in bradycardia and AV block

Question 2

Selective Beta 1 -agonists

Dobutamine

Answer 2

used mainly in acute heart failure

Question 3

Selective Beta 2 -agonists
salbutamol (albuterol)
orciprenaline (metaproterenol)
fenoterol
salmeterol (long-acting)

Answer 3

In bronchial asthma,

Question 4

Selective Beta 2 -agonists
hexoprenaline,
ritodrine

Answer 4

For prevention of preterm labor

Question 5

Selective Beta 3 agonists : Mirabegron

Answer 5

used in overactive urinary bladder.
The mechanism of action is relaxation of smooth
musles of the urinary bladder (detrusor).

most dangerous adverse effect is increase of the
blood pressure (the mechanism is unknown). So,
it is contraindicated in severe hypertension.

Question 6

Effects of beta-adrenergic agonists

Answer 6

● increase of heart rate and contractility;
● dilation of vessels (mainly in skeletal muscles)
● slight increase of systolic pressure, decrease of
diastolic and mean blood pressure;
● bronchial dilation;
● decrease of contractility of myometrium

Question 7

ADVERSE EFFECTS OF BETA ADRENERGIC AGONISTS

Answer 7

Tachycardia, hypotension, tremor