Alpha,Beta Adrenergic agonists

Question 1

Application of Epinephrine

Answer 1

1. Anaphylactic shock – IM or SC (life-saving drug!)
2. Cardiac arrest – directly into the heart
3. Prolongation of local anesthesia – added to solutions of the local anesthetics
4. Bleeding (as a topical hemostatic agent)
5. Bronchial asthma – IM or SC

Question 2

Norepinephrine

Answer 2

sometimes is uses as IV infusion in acute hypotension (shock)

Question 3

Mixed acting: Ephedrine

Answer 3

combines direct action (activation of alpha- and beta-adrenoceptors and indirect action

Question 4

Indirectly acting: Amphetamine

Cocaine

Answer 4

Do not bind to adrenoceptors, but increase release of norepinephrine to the synaptic cleft or inhibit reuptake
of norepinephrine (cocaine).