Alpha -adrenergic agonists

Question 1

phenylephrine (Alpha1)

Answer 1

acute hypotension
as a mydriatic agent (examination of
retina)

Question 2

midodrine (Alpha1)

Answer 2

chronic hypotension,
orthostatic hypotension (per os)

Question 3

xylometazoline
oxymetazoline
nafazoline ( all prefers Alpha 2)

Answer 3

nasal decongestants
(decrease nasal congestion due to vasoconstriction and decrease of the volume of the
nasal mucosa; lose effect in long-term administration causing “rebound” congestion)

Question 4

clonidine,

methyldopa (Alpha 2)

Answer 4

arterial hypertension
(decrease blood pressure due to 2
receptors of nucleus tractus solitarii)

Question 5

Central effects of clonidine

Answer 5

● Sedation
● Analgesia
● Decrease symptoms of opioid abstinence syndrom

Question 6

ADVERSE EFFECTS OF ALPHA ADRENERGIC AGONISTS

Answer 6

Vasoconstriction, hypertension