Behavioural Genetics Flashcards

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1
Q

It is no longer a question of nature or nurture, what do we now want to know?

A
  • What is the relative contribution of nature and nurture.

- What are the mechanisms by which they interact to affect biology and behaviour.

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2
Q

What was the structure of DNA based on?

A

150 years of research by other scientists.

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3
Q

How many strands/chains of nucleotides does a DNA molecule have?

A

2, running in opposite directions and coiled in a. double helix.

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4
Q

What are the designated sex chromosomes in humans?

What do females have?

What do males have?

A

X & Y

XX

XY

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5
Q

What gender determines the sex of a child?

A

Male, females contribute the X chromosome but men contribute either X or Y, determining the gender.

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6
Q

Give an example of a condition caused by a mutation that alter a protein?

A

Sickle cell anaemia

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7
Q

How many base pairs are there in a human chromosome?

A

Between 50million to 300 million.

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8
Q

When was the Human genome project completed and what is it?

A

2003 and it sequences the full human genome.

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9
Q

What is a variant of a gene called?

A

an allele

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10
Q

What 3 categories can genes be?

A

Dominant, recessive ot intermediate.

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11
Q

What types of conditions does a dominant gene show a strong effect in?

A

Homo or heterozygous condition

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12
Q

What type of condition does a recessive gene show affects in?

A

Only homozygous

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13
Q

We inherit our sensitivity to certain types of bitter taste. What evolutionary implications did this have in early humans?

What behavioural implication does this have in modern humans?

A

Humans with the dominant gene are better able to taste/avoid toxins.

Humans with the dominant gene are more sensitive to the bitter taste of tobacco and vegetables in the cabbage family. This may make them less likely to smoke and less likely to eat broccoli.

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14
Q

What % of variance does the bitter taste gene account for in PTC tasting?

A

85%.

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15
Q

What physical factors is tasting ability affected by?

A

What you have had to eat/drink before, the dryness of your mouth and sensitive can change over time.

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16
Q

Some genes are active only at certain point in one’s life, a certain time of day etc. What are changes in gene expression central to?

A

Learning and memory.

17
Q

Epigenetic differences are a likely explanation for what type of twins?

A

Monozygotic (identical).

18
Q

Genes and sleep: What parts of the Brian are stimulated by light?

A

photopigment melanopsin of the retinohypothalmic path.

The signal travels along to the suprachiasmatic nucleus of the hypothalamus.

19
Q

What part of the brain refers all the peripheral clocks in the body?

What does this do?

A

The suprachiasmatic nucleus

Maintains circadian rhythms. e.g., by regulating melatonin production in the pineal gland which increases sleepiness.

20
Q

What does light trigger in the suprachiasmatic nucleus?

Example?

A

A complex sequence of processes in SCN neurons, leading the the expression of circadian clock genes.

Per1 which can be induced within 5-15minsw of a light pulse.

21
Q

What animal study gave the first information about circadian clock genes?

A

study of fruitflies

22
Q

What 2 types of genes are responsible for generating the circadian rhythm in fruit flies?

A
  1. Period genes - produce proteins called PER

2. Timeless genes - produce proteins called TIM.

23
Q

What do PER and TIM both promote?

A

inactivity and sleep.

The concentration of PER and TIM oscillates over a day.

24
Q

Fruit flies:
What is the general pattern of synthesis for PER and TIM?

What follows this?

A

They are very low at sunrise (as shown by mRNA) but increases throughout the day.

An increase in levels of the proteins themselves - so that PER and TIM levels are high during the night.

25
Q

Give 2 examples of circadian rhythm sleep disorder.

A
  1. Familial advanced sleep phase disorder (ASPD)

2. Familial natural short sleepers (FNSS)

26
Q

What % of variance in morningness-eveningness is heritable?

A

54%.