Behavioral Science

Question 0

What is contraindicated in patients that are on MAO-I’s?

Answer 0

Tyramine- abundantly found in things like wine and blue cheese. The vignette will usually describe a person that has an uncontrolled diet and thus is contraindicated. Phentolamine given when the person is on the MAO-I, and eats things with tyramine.

Question 1

Name the drug that is a MAOi-B and what is it used for?

Answer 1

Selegeline - used in patients that have Parkinson’s Disease.

Question 2

What is the MOA of Tricyclic Anti-Depressants (5 things)?

Answer 2

Blocks catecholamine re-uptake
Blocks alpha-1 receptors
Interferes with AV Nodal Conduction
Strongly anticholinergic
Anti-histamine

Question 3

Which Tricyclic AD is associated with first line treatment of chronic pain?

Answer 3

Amitriptyline

Question 4

Which Tricyclic AD is used for second line bed wetting? That is first line treatment?

Answer 4

First line treatment: behavior modification.

Second line: Imipramine

Question 5

Which TCA has the least amount of effects on blood pressure?

Answer 5

Nortriptyline - good for use in elderly patients

Question 6

Which TCA has the least amount of side effects over all?

Answer 6

Desipramine - good for use in elderly patients

Question 7

Name the TCA that is associated with second line treatment of OCD:

Answer 7

Clomipramine

Question 8

Name the three main side effects of TCAs (3):

Answer 8

Coma
Cardiotoxicity
Convulsions

Question 9

Stimulants- name their MOA and their clinical use (3):

Answer 9

MOA- blocks catecholamine re-uptake.
Clinical use: 
ADHD
Narcolepsy 
Appetite suppression

Question 10

Name the 3 therapeutic stimulants, and their side effects (3):

Answer 10

Methylphenidate, dextroamphetamine, Methamphetamine.

SE: hypertension, tachycardia, and anorexia

Question 11

What is the MOA if SSRI’s?

Answer 11

They increase the extracellular levels of neurotransmitter serotonin (5-HT) by inhibiting its reuptake into the presynaptic cell, thus increasing the amount of serotonin in the synaptic cleft available to bind to the postsynaptic receptor.

Question 12

This SSRI is most commonly used for the treatment of PTSD:

Answer 12

Sertraline- Sir-yes-ser!

Zoloft!

Question 13

This SSRI is commonly used to treat depression, social phobia, and premature ejaculation.

Answer 13

Paroxitine

Question 14

This SSRI is most commonly used to help restore memory in patients that have suffered a stroke:

Answer 14

Escitalopram

Question 15

What are some of the side effects associated with the use of SSRIs (2:5)?

Answer 15

Anorgasmia
Serotonin syndrome:
Hyperthermia 
Confusion
Diarrhea 
Seizures
Cardiovascular collapse

Question 16

What is the MOA of SNRIs? What is their major use?

Answer 16

Serotonin-norepinephrine reuptake inhibitor- inhibit reuptake of both 5-HT and NE.

Are a class of antidepressants used to treat major depression and other mood disorders (ADHD, OCD, fibromyalgia syndrome, and chronic neurotic pain).

Question 17

Name the two SNRI medications, and which one have more of an effects on NE?

Answer 17

Venlafaxine-depression

Duloxetine- depression + increased NE effect.

Question 18

What medication blocks the reuptake of NE? What are its side effects (3)?

Answer 18

Maprotiline- Orthostatic hypOtension and sedation.

Question 19

What medication is most commonly used for smoking cessation, and what is its MOA with SEs:

Answer 19

Bupropion: MOA - increases NE and Dopamine levels.

SE: pro-convolucent - Lowers seizure threshold.

Question 20

What medication in the azapirone class of meds is most commonly used to treat generalized anxiety disorder?

Answer 20

Buspirone

Question 21

What is the MOA of benzodiazepines?

Answer 21

They increase the frequency of Chloride channels in the brain.

Question 22

What is the shortest acting benzodiazepine?

Answer 22

Alprazolam

Question 23

What is the longest acting benzodiazepine?

Answer 23

Flourazepam

Question 24

Which benzodiazepine is used as second line for absence seizures?

Answer 24

Clonazepam

Question 25

These benzodiazepines are used as sleep meds- one puts you to sleep, one maintains sleep, and another gives a particular side effect. Which are they?

Answer 25

Triazolam - puts you to sleep Tamazepam - maintains sleep Trazodone- helps increase REM but gives priapism.

Question 26

What drug is known to give 45 minute retrograde amnesia otherwise known as the date rape drug?

Answer 26

Midazolam

Question 27

Name the two Phenothiazines that have a low potency. What SE are associated with each of them?

Answer 27

Chlorpromazine- decreases BP by blocking Alpha 1 Thioridazine- can cause iris pigmentation.

Question 28

This medication is a high potency Phenothiazine that is used as an anti-emetic in adults. What is this medication?

Answer 28

Perchlorperazine

Question 29

This medication is a high potency Phenothiazine that is used as an anti-emetic in children.

Answer 29

Promethazine

Question 30

This medication is a high potency Phenothiazine that is used in a depot form for use as an antipsychotic. What is it?

Answer 30

Fluphenazine

Question 31

What are the side effects of Phenothiazines?

Answer 31

Extrapyramidal System-pseudoparkinsonism, dystonia, dyskinesia, opisthotonos, and hyperreflexia.

Question 32

Name a high potency Butrephenon (antipsychotic): it usually knocks out people very fast.

Answer 32

Haloperidol

Question 33

Antipsychotics: Butrephenons- atypicals: this medication is used a gold standard. Side effects include agranulocytosis, neutropenia, seizures.

Answer 33

Clozapine

Question 34

Antipsychotics: Butrephenons- atypicals: this medication is associated with weight gain.

Answer 34

Olanzapine

Question 35

Antipsychotics: Butrephenons- atypicals: this medication is associated with side effects like having an increase in prolactin.

Answer 35

Respiradone

Question 36

Antipsychotics: Butrephenons- atypicals: this medication's known side effect is the presence of cataracts.

Answer 36

Quetiapine

Question 37

Antipsychotics: Butrephenons- atypicals: this medication's side effects include: possible prolonged QT.

Answer 37

Ziprasidone

Question 38

Antipsychotics: Butrephenons- atypicals: this medication is also known as Abilify, and is used to treat schizophrenia, bipolar disorder, Major depression, and tic disorders.

Answer 38

Aripiprazole

Question 39

What is the MOA of MAO-Is?

Answer 39

Block mono-amine oxidase. They increase serotonin, NE, and Dopamine.

Question 40

Name the three MAOi-A medications:

Answer 40

Tranylcypromine, Isocarboxacid, and Phenelzine.

Question 41

Name the MAOi-B medication:

Answer 41

Selegeline

Question 42

Mood Stabilizers: this medication first blocks Na+ then blocks Ca2+. What are the associated fetal SEs?

Answer 42

Valproic Acid - SE: Split spine, neural tube defects, and bone marrow suppression.

Question 43

Mood stabilizers: what is the MOA of Lithium? What are the fetal SE of its use?

Answer 43

MOA: blocks the dephosphorylation of IP3-DAG. SE: Epsteins Anomaly: Right atrium gets bigger, left atrium gets smaller, and thus causes a decrease in BP.