BCHM 2 Lipids and lipoproteins Flashcards
energy storage
pound for pound TAGs contain how much energy as carbs?
how much storage of Glucose, glycogen, protein, TAGs?
Glycerol vs Mono/Di/triacyl glycerol
sources of triacylglycerol
TAG synthesis in intestinal cells
what are the staring materials?
what do they get packaged into?
where are they released to?
What promotes synthesis?
TAG synthesis in the liver
what are the starting materials?
what do they get packaged into?
where are they released to?
promoted by?
Key point about liver specificity and enzyme
TAG synthesis in adipocytes
what are the starting materials?
where do we get the staring materials?
what enzyme plays a key role?
stored where?
released where?
Promoted by what?
Breakdown of TAGs
(Old style)
what enzymes? do what?
what is a + reg a - reg?
releases what?
how do these get transported?
mechanism of regulation of HSL
activity modulated by?
major signals that promote mobilization?
controllers of the signaling?
what inhibits mobilization?
Breakdown of TAGs
(revised)
what new enzymes do what?
ATGL for TAG to DAG
HSL DAG to MAG
the others are the same
LPL DAG to MAG
and MAG to glycerol via MAG lipase
there is a little overlap of fucntion
knockout mouse without HSL had build up of DAG not TAG like expected ATGL was converting
proteins that coat lipid droplets in adipocytes and muscle cells?
regulate what? how?
how activated?
overexpression vs knock-out?
cholesterol biosynthesis
starts from?
happens were?
What does Statins work on?
Lipoproteins
serve as what?
structure?
contributes to what?
Different types of lipoproteins
composition of lipoproteins
Size differences?
chylomicrons vs HDL composition?
LDL?
Chylomicron
apolipoproteins?
properties?
VLDL, IDL, LDL
apolipoproteins?
characteristics?
HDL
apolipoproteins?
Properites?
!!!!!!
Chylomicron processing
assembled with what?
what makes them mature?
where do those come from?
what breaks them down?
what is released?
how does it bind?
VLDL, IDL, LDL processing
Start with what? from where?
what breaks this down?
loses what?
turns into?
what breaks that down?
into what?
How is LDL uptook?
HDL processing
what enzymes used?
benefits of HDL?
ability to reverse what?
what does HDL-C do?
how do we increase it?
Type I Hyperlipoproteinemia
AKA?
inability to?
What is the Cause?
infancy vs post-adolescence?
Plasma TAG?
symptoms?
what happens to stored blood?
Xanthomas are eye growths
Type II Hyperlipoproteinemia
AKA?
cause?
leads to?
Heterozygous vs homozygous?
symptoms?
hetero/homo treatment
Cholesterol and Atherosclerosis
