BCHM 1 Coagulation Cascade Flashcards
primary hemostasis
Secondary hemostasis
Seconddary hemostasis: endothelial cells release what when damaged?
what does it do?
Vitamin k-dependent factors
what does vitamin K do?
some reasons or cases with low vit k?
extrinsic pathway
initiation of pathway involves what?
Step 1 and 2 of the extrinsic coagulation pathway?
Steps 3, 4, and 5 of the extrinsic pathway?
intrinsic coagulation pathway
also called?
initiation of pathway involves?
Step 1 and 2 of the intrinsic system
Step 3, 4, and 5 of the intrinsic system
step 6, 7, and 8 of the intrinsic pathway
Step 1, 2 , and 3 of the common pathway
Central role of thrombin
1.?
What does factor XIIIa do?
central role of thrombin
2.?
Propagation is basically an amplification of the cascades
Central role of thrombin
3.?
examples of integration of the intrinsic and extrinsic pathways?
Testing secondary hemostasis
what are the two tests?
which pathway do they test for?
aPTT and PT
which factors do each look for?
what is used for these tests?
how do you prepare?
Activated partial thromboplastin time
why partial?
what pathway does it test for?
what factor defects possible?
clinical correlations?
Heparin therapy? what is it? what does it work on?
Hemophilia
deficiency of what?
most common causes of a prolonged aPTT?
Prothrombin time
measures what pathway?
detect defects in?
clinical correlation?
coumadin thereapy?
what factors affected?
Vitamin K defic?
Warfarin
most common causes of prolonged prothrombin time?
