Basic principles of gastrointestinal absorption. Absorption of water, ions, vitamins and nutrients Flashcards
Basic principles of gastrointestinal absorption - SURFACE AREA
SURFACE AREA
- rugae folds = large surface area
- villi = finger projections coming out of folds
- microvilli = coming out of villi forming brush border of small intestine
Basic principles of gastrointestinal absorption - TIGHT JUNCTIONS
located between adjacent enterocytes
to control what enters/ exits
Basic principles of gastrointestinal absorption - ENZYMES
ENZYMES
- lipase: triglycerides -> fatty acids + glycerol
- amylase: complex carbohydrates -> simple sugars
- pepsinogen: proteins -> amino acids
Basic principles of gastrointestinal absorption - transport type 1
passive diffusion
high conc to low conc
- no energy needed
Basic principles of gastrointestinal absorption - transport type 2
facilitated diffusion
high conc to low conc
using specific transport proteins
Basic principles of gastrointestinal absorption - transport type 3
active transport
low conc to high conc
- using ATP
Basic principles of gastrointestinal absorption - transport type 4
ENDOCYTOSIS
bulk transport into cell using vesicular transport
Basic principles of gastrointestinal absorption - MICROBIOTA
gut bacteria involved in vitamin synthesis
Basic principles of gastrointestinal absorption - REGULATION
REGULATION
NEURAL
HORMONES (5)
MECHANICAL
REFLEX - ENTEROGASTRIC
Basic principles ofgastrointestinal absorption - PERMEABILITY
PERMEABILITY
paracellular transport
transcellular transport
ABSORPTION OF WATER - 1
small intestine
= main site to absorb water
- by osmosis/ active/ passive
ABSORPTION OF WATER - 2
large intestine
= secondary site
absorbs water out of chyme leaving stool (poop)
ABSORPTION OF IONS - active
sodium
calcium
ABSORPTION OF IONS - passive
chloride
potassium
ABSORPTION OF VITAMIN - fat soluble
fat soluble = ADEK
- absorbed in jejunum
incorporated into micelles put into epithelial cells
then
incorporated into chylomicrons put into lymphatic system -> bloodstream