basic concepts of biosafety and biosecurity Flashcards

1
Q

Brief history of laboratory biosafety:
In 1967, there is an increase in… and… due to the…

A

Mortality & morbidility
Smallpox

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2
Q

Brief history of laboratory biosafety:
When was the serious concerns about the biosafety practice worldwide were raised

A

1967

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3
Q

Brief history of laboratory biosafety:
Where did the serious concerns about biosafety practices worldwide were consolidated?

A

Russia: State Research for Virology and Biotechnology VECTOR
US: Centers for Disease Control and Prevention (CDC)

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4
Q

Brief history of laboratory biosafety:
Who described the use of mechanical pipettors to prevent laboratory acquired infections

A

Arnold Wedum

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5
Q

Brief history of laboratory biosafety:
When was the use of mechanical pipettors to prevent laboratory acquired infections?

A

1907 & 1908

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6
Q

Brief history of laboratory biosafety:
Who is the director of Industrial Health and Safety in 1944

A

Arnold Wedum

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7
Q

Brief history of laboratory biosafety:
Who provided the foundation for evaluating the risks handling infectious microorganisms

A

One of the pioneers of biosafety

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8
Q

Brief history of laboratory biosafety:
The use of mechanical pipettor is to prevent…

A

Laboratory acquired infections

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9
Q

Brief history of laboratory biosafety:
When did the pharmaceutical company in Pennsylvania developed a ventilated cabinet to prevent infection from myobacterium tuberculosis

A

1909

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10
Q

Brief history of laboratory biosafety:
The pharmaceutical company in Pennsylvania developed a … to prevent …

A

ventilated cabinet
infection from myobacterium tuberculosis

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11
Q

Brief history of laboratory biosafety:
Who developed a ventilated cabinet to prevent infections from mycobacterium tuberculosis

A

A pharmaceutical company in Pennsylvania

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12
Q

Brief history of laboratory biosafety:
When did the US biological weapons program began and who ordered it

A

1943, US President Franklin Roosevelt

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13
Q

Brief history of laboratory biosafety:
When did WHO aggressively pursued the eradication of the virus

A

1967

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14
Q

Brief history of laboratory biosafety:
How did the WHO aggressively pursued the eradication of the virus

A

Through vaccination

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15
Q

Brief history of laboratory biosafety:
Newell A. Johnson developed what technical solutions?

A

Class III Safety Cabinets and laminar flow hoods

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16
Q

Brief history of laboratory biosafety:
Camp Detrick was renamed to

A

Fort Detrick

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17
Q

Brief history of laboratory biosafety:
Who analyze the multiple epidemiological studies for laboratory-based outbreak

A

Wedum and microbiologist Morton Reitman

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18
Q

Brief history of laboratory biosafety:
when did Wedum and Morton Reitman analyzed multiple epidemiological studies of laboratory-based outbreak

A

1966

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19
Q

Brief history of laboratory biosafety:
Who is the microbiologist and a colleagues at Fort Detrick

A

Morton Reitman

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20
Q

Brief history of laboratory biosafety:
Who terminated the US biological weapons program

A

US President Richard Nixon

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21
Q

Brief history of laboratory biosafety:
When was the Biological weapons program terminated

A

1969

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22
Q

Brief history of laboratory biosafety:
When did the CDC published Classification of Etiological Agents on the Basis of Hazard

A

1974

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23
Q

Brief history of laboratory biosafety:
In 1974, what did the CDC published

A

Classification of Etiological Agents on the Basis of Hazard

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24
Q

Brief history of laboratory biosafety:
When was the national Institution of Health published NIH Guidelines for Research Involving Recombinant DNA Molecule

A

1976

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25
Q

Brief history of laboratory biosafety:
In 1976, what did the national Institution of Health published

A

NIH Guidelines for Research Involving Recombinant DNA Molecule

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26
Q

Brief history of laboratory biosafety:
When was the World Health Organization’s first edition of Laboratory Biosafety Manual

A

1983

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27
Q

Brief history of laboratory biosafety:
In 1983, what is the World Health Organization’s first edition

A

Laboratory Biosafety Manual

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28
Q

Brief history of laboratory biosafety:
When did NIH and CDC’s joint-published first edition of Biosafety in Microbiological and Biomedical Laboratories

A

1984

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29
Q

Brief history of laboratory biosafety:
In 1984, NIH and CDC’s joint-published first edition of

A

Biosafety in Microbiological and Biomedical Laboratories

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30
Q

Technical means of mitigating the risk of accidental infection from or release of agents in the laboratory setting as well as the community and environment it is situated in.

A

Biosafety levels

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31
Q

Brief history of laboratory biosafety:
Progress of biosafety continued until the emergence of a community of “___” who adopted the administrative role of ensuring that the ____ and ____ are in place

A

“biosafety officers”
proper equipment
facility controls

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32
Q

Identify:
1. Classification of Etiological Agents on the Basis of Hazard
2. Laboratory Biosafety Manual
3. Biosafety in Microbiological and Biomedical Laboratories
4. NIH Guidelines for Research Involving Recombinant DNA molecule

A
  1. CDC
  2. WHO’s first edition
  3. NIH and CDC’s joint-published
  4. National Institute of Health
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33
Q

Brief history of laboratory biosafety:
Who became the first scientific director of camp detrick

A

Ira L. Baldwin

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34
Q

Brief history of laboratory biosafety:
Ira L. Baldwin became the first…

A

First scientific director of camp detrick

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35
Q

Brief history of laboratory biosafety:
Newell A. Johnson engaged some of Camp Detrick’s leading scientist about the…

A

nature of their work

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36
Q

Brief history of laboratory biosecurity:
Which year did the US government enacted Select Agent Regulation

A

1966

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37
Q

Brief history of laboratory biosecurity:
In 1966, the US Government enacted…

A

Select Agent Regulation

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38
Q

Brief history of laboratory biosecurity:
Who monitor the transfer of a select list of biological agents from one facility to another

A

Select agent Regulation

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39
Q

Brief history of laboratory biosecurity:
When was the revised agent regulation the requires specific security measures for any facility in the United Staes that used or stores one or more agents on the longer list of agents

A

2001

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40
Q

Brief history of laboratory biosecurity:
In the Select Agent Regulation in 2012, how many of tiers of select agents are there

A

Two tier of select agents

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41
Q

Brief history of laboratory biosecurity:
Materials that pose the greater risk of deliberate misuse and the remaining select agents

A

Tier 1 agents

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42
Q

What is Singapore select agent regulation

A

Biological agent and toxins act

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43
Q

What is South Korea select agent regulation

A

Act on prevention of infectious disease (2005)

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44
Q

What is Japan select agent regulation

A

Infectious disease control law

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45
Q

What is Canada select agent regulation

A

Containment Levels 3 and 4

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46
Q

Identify the country:
Act on prevention of infectious disease
Containment levels 3 and 4
Biological agent and toxins act
Infectious disease control law

A

South Korea (2005)
Canada
Singapore
Japan

47
Q

When was the biological agent and toxins act introduced

A

October 2005

48
Q

When was the biological agents and toxins enacted

A

January 2006

49
Q

What is the European committee for standardization

A

(CEN) Comite Europeen de Normalisasyon

50
Q

What do Comite Europeen de Normalisasyon published

A

(CWA 15793) CEN Workshop Agreement 15793

51
Q

What do (CWA 15793) focuses on

A

Laboratory biorisk management

52
Q

It is applied to international stakeholders, however, they do not have the force of regulation while conformity is voluntary

A

CWA 15793

53
Q

CWA 15793 is applied to …, however, they do not have the force of regulation while conformity is…

A

international stakeholders
voluntary

54
Q

CWA 15793 has experts from how many country

A

24

55
Q

When did WHO published the 3rd edition of Laboratory Biosafety Manual which includes information on the different levels of containment laboratories

A

1983

56
Q

When did the European committee for Standardization published CEN Workshop Agreement 15793 (CWA 15793)

A

Feb 2008

57
Q

In 1983, WHO published the…

A

3rd edition of laboratory biosafety Manual

58
Q

What is included in the 3rd edition of laboratory biosafety Manual

A

The different levels of containment laboratories

59
Q

Cartagena protocol on biosafety is made effective in..

A

2003

60
Q

What is made effective in 2003

A

Cartagena protocol biosafety (CPB)

61
Q

Cartagena protocol on biosafety applies to the…

A

168 - member countriess

62
Q

Cartagena protocol on biosafety ensure an adequate level of protection in the field of ____ , ____, and ____

A

safe transfer
handling
use of living modified organisms

63
Q

What is the executive order of the National Committe on Biosafety of the Philippines

A

E.O. 430 Series of 1990

64
Q

National Committe on Biosafety of the Philippines was formed on the … of scientist

A

advocacy efforts of scientist

65
Q

The office of the president promulgated the executive order..

A

E.O. 514

66
Q

When was the office of the president promulgated E.O 514

A

March 17 2006

67
Q

Office of the president promulgated E.O. 514 establishing the

A

National biosafety framework

68
Q

Combination of policy, legal, administrative, and technical instrument developed to attain the ___

A

objective of Cartagena Protocol on Safety

69
Q

Combination of policy, legal, administrative, and technical instrument developed to attain the objective of Cartagena Protocol on Safety which the Philippines signed on…

A

May 24 2000

70
Q

What are the 5 different organizationsin the field of biosafety

A

1.ABSA -America biological safety association
2. EBSA -European biological safety association
3. A-PBA -Asia-pacific biosafety association
4. PhBBA- Philippine biosafety and biosecurity association
5. BRAP -biological risk association Philippine

71
Q

When was the ABSA founded

A

1984

72
Q

When was the A-PBA founded

A

2005

73
Q

When did the EBSA founded

A

June 1996

74
Q

Identify the organizations in the field of biosafety:
Promotes biosafety as a scientific discipline and provides guidance to its members on the regulatory regime present in North America

A

ABSA

75
Q

Identify the organizations in the field of biosafety:
Biosafety professionals in the Asia-Pacific
region.

A

A-PBA

76
Q

Identify the organizations in the field of biosafety:

Aims to provide forum for discussions and debates on issues of concern and to represent those working in the field of biosafety

A

EBSA

77
Q

Identify the organizations in the field of biosafety:
Assists the DA and DOH in their efforts to create a national policy and implements plan

A

PhBBA

78
Q

Identify the organizations in the field of biosafety:
Created by members from health and education sectors from executive, legislative, and judicial branches

A

PhBBA

79
Q

Identify the organizations in the field of biosafety:
Non-government and non-profit association that works to serve the emergent concerns of biological risk management in various professional fields

A

BRAP

80
Q

The members of A-PBA are from

A

Singapore
Brunei
Indonesia
Malaysia
Thailand
China

81
Q

EBSA aims to provide … and … and to represent those working in the field of biosafety

A

Forum of discussion
Debates on issue of concern

82
Q

Focuses on … and … among its members … and … on biosafety and biosecurity

A

Encouraging and communicating
Information and issues

83
Q

PhBBA is created by members from health education sectors from…., …., ….

A

Executive
Legislative
Judicial branches

84
Q

PhBBA included members of the steering committee and technical working groups of the national laboratory biosafety and biosecurity action plan task force established …

A

DPO No. 2006-2500

85
Q

PhBBA assist DA and DOH in their efforts to create a … and …

A

national policy
implement plan

86
Q

As defined by WHO: “The containment principles, technologies, and practices that are implemented to prevent unintentional exposure to pathogens and toxins, or their accidental release.”

A

Biosafety

87
Q

“The protection, control, and accountability for
valuable biological materials within laboratories, in order to prevent their unathuroized access, loss, theft, misuse, diversion, or inential release.”

A

Biosecurity

88
Q

It protects people from germs

A

Biosafety

89
Q

If protects germs from people

A

Biosecurity

90
Q

Who is the environmental health engineer

A

Charles Baldwin

91
Q

Charles Baldwin works for the

A

Dow chemical company

92
Q

Charles Baldwin is a…

A

Environmental health engineer who works for the Dow chemical company

93
Q

Biosafety: The containment principles, technologies, and practices that are implemented to prevent

A

unintentional exposure to pathogens and toxins
or their accidental release

94
Q

The …, …, … for valuable biological materials within laboratories, in order to prevent their unathuroized access, loss, theft, misuse, diversion, or inential release

A

protection, control, and accountability

95
Q

Identify the risk group:

Low individual & community risk.

A

Risk group 1

96
Q

Identify the risk group:

Unlikely to be asignificant risk to lab workers, enviro, community, livestock

A

Risk group 2

97
Q

Identify the risk group:

Significant risk to lab workers

A

Risk group 3 and 4

98
Q

Identify the risk group:
Unlikely to cause human or animal disease

A

Risk group 1

99
Q

Identify the risk group:
May cause infection

A

Risk group 2

100
Q

Identify the risk group:
Serious disease to humans/animals

A

Risk group 3

101
Q

Identify the risk group:
Life threatening disease to humans /animals

A

Risk group 4

102
Q

Identify the risk group:
Effective treatment
Preventive measures

A

Risk group 2 and 3

103
Q

Identify the risk group:
No treatment and readily transmissible from one individual to another

A

Risk group 4

104
Q

Identify the biosafety level:
Suitable for work involving viable microorganisms gar are defined and with well-characterized strains known not to cause disease in humans

A

Biosafety level 1

105
Q

Identify the biosafety level:
Designed for laboratories that deal with indigenous moderate-risk agents present in the community

A

Biosafety level 2

106
Q

Identify the biosafety level:
Emphasis on primary and secondary barriers in the protection of personnel, community and environemt from infectious aerosol exposure

A

Biosafety level 3

107
Q

Identify the biosafety level:
Work with indigenous and exotic agents with a potential for respiratory transmission and may cause serious and potentially lethal infection

A

Biosafety level 3

108
Q

Identify the biosafety level:
Required for work with dangerous and exotic
agents that pose high individual risks of life-threatning disease that may be transmitted via he aerosole route which there are no available treatment or vaccine

A

Biosafety level 4

109
Q

Identify each laboratory biosafety according to levels:
Indigenous and exotic agent
Viable microorganisms gar
Dangerous and exotic agents
Indigenous moderate-risk agents

A

Biosafety level 3
Biosafety level 1
Biosafety level 4
Biosafety level 2

110
Q

What are some examples of biosafety level 1

A

Bacillus subtilis, Naegleria gruberi, infectious canine hepatitis virus and exempt organisms

111
Q

What are some examples of biosafety level 2

A

Hepatitis B virus, HIV, salmonellae, and Toxoplasma species

112
Q

What are some examples of biosafety level 3

A

Mycobacterium tuberculosis, St. Louis encephalitis virus, and Coxiella

113
Q

What are some examples of biosafety level 4

A

Margburg or the Crimean-Congo hemorrhagic fever