Basal Ganglia Flashcards

1
Q

Which structures are found in the rostral (upper) part of the basal ganglia?

A

Striatum
Globus Pallidus

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2
Q

Which structures are found in the caudal (lower) part of the basal ganglia?

A

Subthalamic nucleus
Substantia nigra

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3
Q

What does the caudate nucleus run along the walls of?

A

Lateral ventricles

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4
Q

What structure is found lateral to the caudate nucleus?

A

Putamen

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5
Q

What 2 structures form the striatum?

A

Caudate nucleus
Putamen

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6
Q

Which part of the brain is the substantia nigra located in?

A

Mesencephalon

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7
Q

Where is the red nucleus located in relevance to the substantia nigra?

A

Above it

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8
Q

What types of circuits are found in the basal ganglia?

A

Motor circuit
Limbic circuit
Oculomotor circuit

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9
Q

What motor disorders are associated with basal ganglia dysfunction?

A

Parkinson’s disease
Huntington’s disease
Dystonia
Gilles de la tourette syndrome

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10
Q

What psychiatric disorders are associated with basal ganglia dysfunction?

A

Obsessive compulsive disorder
Attention deficit hyperactivity disorder (ADHD)

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11
Q

What secondary damage are associated with basal ganglia dysfunction?

A

Cerebral palsy
Wilson disease

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12
Q

How is Parkinsons disease associated with dopamine levels?

A

Not enough dopamine

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13
Q

How is Huntingtons disease associated with dopamine levels?

A

Too much dopamine

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14
Q

What are some features of Parkinsons?

A

Increased muscle tone
Reduced movements

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15
Q

What are some features of Huntingtons?

A

Decreased muscle tone
Overshooting movements

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16
Q

What are the 3 cardinal features of Parkinsons disease?

A

Brady/akinesia
Tremor
Rigidity

17
Q

What are the clinical features of Huntingtons disease?

A

Chorea
Dementia/pyschiatric illness
Personality change

18
Q

What are the clinical genetics of Huntingtons disease?

A

Autosomal dominant
Fully penetrant