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Final Biochem > Bartling Pt. 2 > Flashcards

Bartling Pt. 2 Flashcards

1
Q

intrinsic enzymatic activity receptors are ligand ____

A

ligand triggered protein kinases

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2
Q

intrinsic receptors form dimers upon

A

dimers upon ligand bonding

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3
Q

phosphorylation activates

A

other protein kinases

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4
Q

ion channel receptors change confirmation from

A

ligand binding

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5
Q

ion channel receptors allow specific ions to

A

flow through channel

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6
Q

botulinum toxin affects ion channels directly/non directly

A

not directly

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7
Q

botulinum toxin prevents release of

A

acethylcholine neurotransmitter

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8
Q

botulinum toxin cleaves proteins involved in

A

docking of neurotransmitter vesicles

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9
Q

intracellular/extracellular calcium concentration gradient

A

100nM/1mM

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10
Q

calcium gradient enables rapid changes in Ca concentration via

A

hormone ligation

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11
Q

calcium binds to

A

calmodulin (induces conformational change)

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12
Q

calmodulin: two globular domains joined by a

A

long alpha helix

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13
Q

calcium/calmodulin complex binds to and modifies

A

target kinase proteins that initiate signal cascade

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14
Q

PIP2 is second messenger responsible for

A

responsible for calcium mobilization

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15
Q

PIP2 is hydrolized by

A

phospholipase C (PLC)

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16
Q

hydrolized PIP2 generates what 2 second messengers

A

IP3 and DAG

17
Q

IP3 is ____ soluble and mobilizes _____

A

water soluble and mobilizes calcium

18
Q

DAG is anchored in ____ and activates key protein ____

A

anchored in plasma membrane (hydrophobic fatty acid side chains) and activates protien kinase C (PKC) family

19
Q

DAG generated by

A

PLC

20
Q

phosphatidic acid generated by

A

PLD

21
Q

arachidonic acid generated by

A

PLA2

22
Q

arachidonic acid and prostaglandins are key

A

inflammatory and pain mediator

23
Q

arachidonic acid is precursor of

A

eicosanoids

24
Q

eicosanoids examples

A

prostaglandins, luekotrienes

25
Q

eicosanoids act like

A

hormones and signal via G-protein coupled receptors

26
Q

arachidonic acid conversion to prostaglandins involves a

A

cyclooxygenase isoforms

Final Biochem (6 decks)

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