Bacterio6 Flashcards
Salmonella typhimurium causes only ……
Gastroenteritis
Salmonella typhimurium have a (broad/narrow) host range
Broad
Salmonella typhi lost the …. genes and became host……(narrow or broad), it’s (imvasive or not)……
Generalist genes
Host restricted (narrow)
Invasive
Salmonella dublin and cholerasuis are host …….( restricted or adapted), and they are part of …….. of cow and pig respectively.
Adapted
NF
Typhoid fever aka….. fever, the specific cell for salmonella infection is the ….. cell crossing it by ……., this will cause hyperplasia of ……..
Enteric fever
M cell
Transcytosis
Peyer’s patches
T or F
V.cholera have an inoculum size less than salmonella
False
Salmonella affects other organs: ……. and …… , where in the latter it can remain dormant but still can be transmitted
Liver and gallbladder
……. appearance on skin is caused by salmonella
Rose spots
T or F
We can rely on the appearance of rose spots to diagnose salmonella
False
T or F
Salmonella can cause perforation
True
How to treat salmonella patients?
Ceftriaxone IM
Dessert🧇
The diarrhea in case of enteric fever is called….
Pea-soap diarrhea🥲
Sickle cell anemia patients have a higher risk of developing…….. after infection with salmonella
Osteomyelitis
T or F
Salmonella can cause constipation
True
T or F
Salmonella can cause leukopenia
True
Salmonellosis aka….. is caused by two salmonella families …… and……, characterized by …… diarrhea,where we (should/not) give antibiotics because…….
Enterocolitis
Typhimurium and enteritidis
Profuse diarrhea
Shouldn’t give because this will increase carriage time
There are 3 types of salmonella vaccine list them
Killed vaccine heated
Live (attenuated) Ty21A
Vi vaccine
(killed, attenuated and polysaccharide)
Campylobacter jejuni have a ……. appearance, and ….. flagella, grows on …… medium, grows on (high/low)…… temperature and (aerobic or microaerophilic)…..
The inoculum of campy jejuni is ……
- sea gull apearance or comma
- 2 flagella each on one side (bipolar)
- skirrow (vancomycin,polymixin and trimethoprim)
- high (42)
- microaerophilic
- 1000
Source of infection of campylobacter jejuni:….
Poultry (meat - chicken and milk)
Symptoms of campylobacter jejuni:
Nausea Diarrhea (often bloody) Vomiting Fever Most common cause of gastroenteritis in US
T or F
Campylobacter jejuni are not invasive
False
Can cause transient bacterimia
…… can cause reactive arthritis (reiter’s syndrome)
Campylobacter fetus
T or F
Reiter’s syndrome is cause by campylobacter fetus after bacterimia
False
It’s immunopathological ( cross reaction)
T or F
Campylobacter fetus can cause bacterimia especially immunocompromised patients
True
Tx of vibrio vulnificus
Doxycycline
Vibrio …… can cause ——- and ——– skin lesions, MR is ——-
Vulnificus
Septicimia
Metastasic
50%
T or F
Vibrio paraheamolyticus and vulnificus infections are caused mainly by sea food
True
T or F
Vibrio vulnificus causes desentry like syndrome
False
T or F
IP for vibrio para. Is long
False
Short
T or F
Vibrio parah. Causes a severe gastroenteritis
False
Self limited
T or F
Vibrio vulnificus can be caused only through GI
False Direct contact ( open wounds + sea water)
Mode of transmission of V.cholera
Fecal oral
T or F
V.cholera is acid labile
True
Grows in basic med ( 8.5-9.5 )
V.cholera survives the acidic medium or the stomach by …..
Buffering effect ( usually present with other substances(eg. Water…))
V cholera charac: ...... shape Ox(.....) Cat (...) Grows on ...... agar Causes ........ stool ...... flagella (Halophilic / thermophilic)
Comma \+ + TCBS Rice watery 1 flagellum Halophilic
T or F
GM1 is the receptor for V.cholera
False
V.cholera toxin
T or F
Tx of v.cholera is tertacycline
False
Prophylaxis for V.cholera
Tetracycline
Azithromycin or erythromycin for children and pregos
Vax for V cholera is …… and induces (permanent/not)…… immunity
Capsular
Not permanent
Modes of transmission of shigella
Fecal oral route
MSM ( man having sex with a man)
Shigella causes ……. colitis
Inflammatory
Shigella is (invasive/not)……, releases …… which is a ….. mediated toxin, this toxin inhibits …….. synthesis
Invasive
Shiga toxin
Chromosomally
Protein
T or F
Salmonella is the number 1 cause of osteomyelitis in sickle cell anemia patients
True
Shigella have (high/low) …….. inoculum,
In immunocompromised patients it causes :
1-
2-
3-
4-
Low Bacterimia Fever Seizure Rectal prolapse
Tx for shigella
Ceftriaxone
T or F
Shigella have low incubation period
False
No IP
T or F
Shigella is a STI
False
Shigella causes ……. due to neurotoxicity
Tenesmus
T or F
In shigella infections we give anti-diarrheal medications
False
Shigella vaccine is called….
No vaccine for shigella
Tx of H.pylori
Triple therapy : proton pump inhibitor,amoxicillin and clarithromycin
Quadriple : proton pump inhibitor, tertracycline, metronidazole and bismuth
List the tests we can use to detect H.pylori
Invasive:
Gastroscopy
Non-invasive:
Serology (IgGs)
Stool antigen test
Urea breath test
T or F
Taking proton pump inhibitors can give a false positive result on urea breath test
False
False negative
H.pylori are urease (—-) , (motile/non)——-, it’s considered as a lifelong (colonization/disease).——– and secretes exotoxins for —— attraction
Urease +
Motile
Colonization
PMN
H.pylori causes :
1——-
2——–
3——– in MALT
Antral gastritis
Peptic ulcer disease (PUD)
Adenocarcinoma
Symptoms caused by H.pylori
1——-
2——-
3——-
Bloating
Decreased appetite
Bad breath odor
How H.pylori remove the mucus allowing the gastric acid to penetrate the tissue and make ulcers?
Binds by adhesins
CagA and Vac A
Secreting urease that will form ammonia
Ammonia will make the neutralize the medium
Virulence factor of H.pylori:
1—-
2—–
3——–
1-Flagella to get into mucus
2-Urease to release ammonia and neutralize the medium
3- CagA and VacA
List the clues and symptoms of enteric fever
- hepatic necrosis (after bacteremia)
- gallbladder inflammation (after bacteremia)
- perforation
- septicimia and sepsis
- hallucination because of fever
- clues : constipation and leukopenia
In HIV patients typhimurium can cause ——– this show that the infection depends on —–/—– interaction, in elderly it can cause —— absceses and ——–
Enteric fever
Germ/host
Splenic
Aortitis
Salmonella can be transmitted by —— animals like ———
Exotic
Lizards, turturles and caoti
T or F
Gram + can cause sepsis by it’s exotoxin
False
By TA
T or F
After shigella infection we have temporary immunity against it
False
Premanent
Classic and eltor cholera are caused by ——- serotype
O1
T or F
Vibrio parahe. Can cause fever
True
Diseases caused by sea food (vibrio) are mainly due to ——-
Global warming
Human are the only hosts for——-
Shigella
T or F
Shigella is invasive and causes bacteremia in immunocompetwnt patients
False
No bacteremia
T or F
Campylobacter jejuni can cause sepsis
False
Only transient bacteremia