Bacterio10

Question 1

Fusobacterium necrophorum and treponema palidum are ——

Answer 1

Spirochetes

Question 2

Treponema pallidum is the main cause of —— and requires a —– microscope to bee seen, has only a —— reservoir and mainly it is a gram —– bacteria

Answer 2

Syphilus
Dark field
Human
Negative

Question 3

——– are flagella and at the end we have ——- , it’s an ——– component unlike all the other, it’s present between ——-

Answer 3

Endoflagella
Basal body
Intracellular
Cell wall and outer membrane

Question 4

Role of cardiolipin

Answer 4

Immunopathological and cross reactivity

Damage of heart

Question 5

T or F

Treponema pallidum have endotoxic activity

Answer 5

False

Question 6

Transmission of trep

Answer 6

Access to dc or macrophages
Broken skin 
Mucosa (wound or not)
Body fluids
Mainly sexual
Congenitally
By blood

Question 7

T or F

Treponema have transposons

Answer 7

False

No resistance

Question 8

Tx of treponema

Answer 8

Penicillin

Question 9

Secondary latentand tertiary syphilus are mainly ——

Answer 9

Immunopathological

Question 10

Describe primary syphilus

Answer 10

Most infectious with the secondary
Chancre (hard)
After sexual contact with person that have syphilus ha yser invasion lal blood (bacteremia)
After 3 weeks bser eendu papule byrja3 ulcer (volcano’s creater) hard and painlessss (aam tehru2 btku herpes)
Ulcers : external genetelia, mouth anus (matrah ma fe sexual activity)
Mesh l kl byamel ulcer (le byaamel bekun lucky)
Bs le byaamel ulcer bekun most infectious
Syphilus destroy lumen of small vesells (no necrosis) this will help in immunopathological reactions
Regional lymphadenopathy (not painful , bilateraaaal (mesh mtl ducreyi) , firm and not suppurative (unlike ducreyi)
Without treatment the patient can be cured
Immunity onlyyyy to chancre

Question 11

Secondary syphilus

Answer 11

After1-2- 3 month of immunity to chancre the patient will develop flu like illness myalgia headache….
Lymphadenopathy not only in inguinal
Generalized macculopapular rash (even on feet and hands)
No palm and soles not syphilus
Alopecia : no hair , patchy hair loss (an be the only manifstation without the rash)
Condylomas (wart like ) mmkn nle2ehn bl 3en w bada 2 organisms bs la taaml l disease
Feha taamel hepatomegaly splenomegaly retinitis glomerulonephritis

Question 12

Tertiary syphilus

Answer 12

Gummas growth (skin bone and liver), granulomatous
Cardiovascular system (aortitis,aneurysm)
Neurosyphilis (akhtar mn dementia)

Question 13

Tests for latent syphilus

Serology (agg tests)

Answer 13

VDRL
TPHA
RPR (rapid plasma reagent)
Have relation with cardiolipin
FTA most accurate

Question 14

T or F

After latent syphilus 30% will heal and 70 will develop tertiary syphilus

Answer 14

False reversed

Question 15

In latent syphilus there is —— of —— symptoms

Answer 15

Reccurence of secondary syphilus symptoms in 25% of individuals

Question 16

Congenital syphilus is before 2 years caused by —– and after 2 years (late ) if ——- can cause :

Answer 16

Both caused by the mother  (transplacentally or by exchange of fluid)
Cleft palate (osteitis)
Abortion or still birth (because of neonatal cardiac problems)
Hutchinson teeth
Mulberry cusp
Saddle nose
Frontal bossing
Stigmata (will live forever with it)