B8.039 Prework 6: Benign & Non-Malignant Breast Lesions Flashcards
1
Q
causes of gynecomastia
A
physiologic in newborn, pubertal and elderly males, but may persist after puberty
cirrhosis, hypogonadism, testicular tumors, drug
2
Q
drugs that cause gynecomastia
A
spironolactone hormones cimetidine finasteride ketoconazole
3
Q
what % of DCIS progresses to invasive cancer if not treated
A
15-50%
4
Q
treatment options for DCIS
A
mastectomy
lumpectomy + radiation + anti hormonal therapy
-radiation and antihormonal therapy reduce risk of recurrence
5
Q
risk of invasive carcinoma after diagnosis of LCIS
A
9-10x general population
6
Q
treatment of LCIS
A
surgical excision not mandated
active surveillance and chemoprevention (anti hormonal therapy) are options
7
Q
hallmarks of LCIS
A
loss of e-cadherin
diffuse cytoplasmic expression of p120 catenin
