B8.036 Breast Path

Question 1

major prognostic factors of breast carcinoma

Answer 1

invasive or in situ disease
distant mets
lymph node mets
-most important
-sentinel lymph node
tumor size
locally advanced disease
inflammatory carcinoma

Question 2

clinical staging for breast carcinoma

Answer 2

T (primary tumor size)
N ( regional lymph nodes)
M ( distant metastasis)

Question 3

minor prognostic factors for breast carcinoma

Answer 3

histological subtypes
tumor grade
-nuclear grade, tubule formation, mitotic rate
ER/PR/Her2/neu

Question 4

ER/PR/Her2/neu general prognostic indications

Answer 4

ER and PR + slightly better
overexpression of her2/neu = poor
predicts response to hormonal therapy

Question 5

ER+
Her2-
low proliferation

Answer 5

luminal A
40-55% of breast cancers
older women
respond well to hormonal therapy

Question 6

ER+
Her2-
high proliferation

Answer 6

luminal B
10% of breast cancers
associated with BRCA2 germline mutations
may respond to chemo

Question 7

Her2+

Answer 7

half ER+, half ER-
20% of breast cancers
young women
respond to targeted therapy (herceptin)

Question 8

ER-

Her2-

Answer 8

15% of breast cancers
more common in young women, AA, and hispanic
may be associated with BRCA1 mutation
may respond to chemo