B8.039 Prework 4: BRCA Genes and Breast Cancer Flashcards
1
Q
BRCA1/2 risks of breast cancer
A
55-65% risk w BRCA1
45% risk w BRAC2
12% baseline risk
2
Q
men with BRCA2
A
increased risk of breast and prostate cancer
3
Q
most common BRCA1 molecular subtype
A
triple neg
higher levels of genomic instability
4
Q
most common BRCA2 molecular subtype
A
luminal B
5
Q
what is the function of BRCA
A
sensing and repairing DNA damage
with mutation:
-loss of efficient DNA repair
-loss of checkpoint regulation
6
Q
what are PARP inhibitors
A
poly ADP ribose polymerase inhibitors used for metastatic breast cancer caused by a BRCA mutation
