B4M1 18-19 Flashcards
The average human possesses how many liters of blood?
A. 3Liters
B. 4Liters
C. 5Liters
D. 6Liters
C. 5Liters
Case: Carmen sustained a cut from a sharp-edged paper which she was folding for her
Christmas decoration.
Which blood component is responsible for the formation of a plug in small vascular
injuries?
A. Neutrophils
B. Lymphocytes
C. Platelets
D. Eosinophils
C. Platelets
Case: Carmen sustained a cut from a sharp-edged paper which she was folding for her
Christmas decoration.
Where do these blood components in question #2 originate from?
A. Plasma cells
B. Polypoid megakaryocytes
C. Myelocytes
D. Rubriblasts
B. Polypoid megakaryocytes
How many days is the survival period of platelets?
A. 1-4 days
B. 4-8 days
C. 8-12 days
D. 12-16 days
C. 8-12 days
Which of the following processes initiates the biosynthesis of Heme?
A. Dehydration
B. Coagulation
C. Condensation
D. Precipitation
C. Condensation
ALA synthase is present in the____.
A. Mitochondria
B. Cytosol
C. Ribosomes
D. Nucleus
A. Mitochondria
Which of the following statements is True of Heme.
A. Porphyrins contain six pyrolle rings linked by four CH groups
B. Has 4 methyl, 2 vinyl and 2 propionic acid side chains attached to a
tetrapyrolle ring
C. Porphyrins are compounds in which side chains are substituted for the 10
hydrogen atoms
D. Composed of a single polypeptide chain and two heme groups
B. Has 4 methyl, 2 vinyl and 2 propionic acid side chains attached to a
tetrapyrolle ring
What compounds are formed by the linkage of four pyrrole rings through methenyl
bridges?
A. Porphins
B. Propionate
C. Porphyrins
D. Protoporphyrins
C. Porphyrins
Which of the following mitochondrial enzymes catalyzes the final step
in heme synthesis
A. Ferrochelatase
B. Protoporphyrinogen oxidase
C. Uroproporphyrinogen decarboxylase
D. Coproporphyrinogen synthase
A. Ferrochelatase
Which of the following components of eosinophils is toxic to helminth parasites?
A. peroxidase
B. acid phosphatase
C. cathepsin
D. major basic protein (MBP)
D. major basic protein (MBP)
A 5-year-old boy was brought by his mother to the pediatrician because of anal
itching. Stool exam revealed a helminth infection.CBC was likewise requested.
Which of the following CBC findings will most probably be consistent with the
presenting symptom of the boy?
A. normal hemoglobin level
B. eosinophilia
C. monocytosis
D. low platelet count
B. eosinophilia
Melissa consulted a doctor because of cough and fever. The physician requested a
CBC and when the result came out the physician informed her that she had a
neutrophil count above the normal. She was prescribed an antibiotic because this
finding indicates what condition?
A. Allergy
B. Bacterial infection
C. Parasitism
D. Loeffler’s syndrome
A. Allergy
Norberto has been undergoing radiation therapy for his cancer. A CBC is always
done after each therapy. The physician noticed that the neutrophil count dropped
below the normal differential count. The term for this is:
A. Neutropenia
B. Leukemia
C. Lymphopenia
D. Neutrophilia
A. Neutropenia
The count of this white blood cell is elevated in cases of tuberculosis:
A. Monocytes
B. Lymphocytes
C. Basophils
D. Eosinphils
A. Monocytes
Basophils in tissues are known as:
A. Mast cells
B. Interleukins
C. Macrophages
D. Phagocytes
A. Mast cells
Cora has acute inflammation of her tonsils. What is the first cellular event in
response to the above condition:
A. increased production of neutrophils
B. infiltration of neutrophils from the blood
C. activation of tissue macrophages
D. increased production of monocytes
C. activation of tissue macrophages
Mary underwent bone marrow biopsy due to an abnormally high wbc count with
immature cells in the circulating blood. Which of the following cells is the earliest
recognizable cell in the monocytic series:
A. Myeloid stem cell
B. Monoblast
C. Promonoblast
D. Monocyte
C. Promonoblast
Identify the monocytes that are found in tissues & tissue spaces:
A. plasma cells
B. T cells
C. natural killer cells
D. macrophages
D. macrophages
The cytoplasm of a prorubricyte is deeply basophilic because of:
A. Azurophilic granules
B. Abundant RNA
C. Lysozymes
D. Chromatophilic granules
B. Abundant RNA
Which of the following is the largest of the erythroid precursors?
A. Prorubricyte
B. Rubricyte
C. Rubriblast
D. Reticulocyte
C. Rubriblast
What is at the surface of the cell membrane of the platelets that causes adhesion to
injured areas of the vessel wall?
A. phospholipids
B. endothelia
C. glycoproteins
D. prostaglandins
C. glycoproteins
Secondary hemostasis is occurring when _______.
A. The platelets begin to swell and contract forcefully.
B. The platelets become sticky and adhere to collagen.
C. The platelets assume irregular shapes with pseudopods.
D. The platelets are bound tightly together with fibrin threads.
D. The platelets are bound tightly together with fibrin threads.
Illustrate the basic steps on how a blood vessel responds when it is cut.
A. Vascular spasm -> constriction -> platelet plug formation -> blood clotting
B. Constriction -> platelets stick together -> cover the break in the vessel wall ->
platelet plug
C. Vascular spasm -> platelet plug -> coagulation
D. Constriction -> platelet plug -> blood clotting
A. Vascular spasm -> constriction -> platelet plug formation -> blood clotting
What is the lifespan of normal red blood cells:
A. 20 – 30 days
B. 40 – 60 days
C. 70 – 85 days
D. 120 days
D. 120 days
In order for red cells to survive its life cycle, which condition is necessary?
A. Amount of O2 must be adequate
B. red cell membrane is permeable
C. sufficient amount of carbonic anhydrase
D. red cell must maintain osmotic balance
D. red cell must maintain osmotic balance
Which of the following factors directly stimulate the kidneys to increase their
production of erythropoietin?
A. Low plasma volume in the blood circulation
B. Increased plasma volume in the blood circulation
C. Low oxygen tension in the kidneys
D. Low white blood cell count
C. Low oxygen tension in the kidneys
Which of the following cells is the progenitor of all formed blood elements in the
bone marrow?
A. Myeloid stem cell
B. Colony forming units
C. Embryonic stem cell
D. Pluripotent stem cell
D. Pluripotent stem cell
Which of the following cells is the progenitor of natural killer(NK) cells?
A. Myeloid stem cell
B. lymphoid stem cell
C. Plasmablast
D. CFU-L
B. lymphoid stem cell
Which of the following major growth inducers promotes the growth and development
of myeloid stem cells?
A. Interleukin-3
B. Interleukin-4
C. Interleukin-5
D. Interleukin-6
A. Interleukin-3
Rogelio was cutting some onions when he accidentally cut his finger which bled
profusely. What is the first step in blood coagulation?
A. Conversion of prothrombin to thrombin
B. Conversion of fibrinogen to fibrin by thrombin
C. Formation of prothrombin activator
D. Adhesion and aggregation of platelets
C. Formation of prothrombin activator
Which factor is a strong accelerator of prothrombin activation in the common
pathway?
A. V
B. Xa
C. IX
D. VIIIa
A. V
Which of the following serves as primarily an erythroid producing organ and also
gives rise to fetal hemoglobin α and δ chains
A. spleen
B. liver
C. thymus
D. bone
B. liver
- From 7 months until birth what assumes the 1° role in hematopoiesis
A. lymph nodes
B. bone marrow
C. liver
D. spleen
B. bone marrow
A positive tourniquet test will be seen in
A. thrombocytopenia
B. thrombocytosis
C. leucopenia
D. increased fibrinogen
A. thrombocytopenia
The mesenchymal, hepatic, and myeloid production, development, differentiation
and maturation of all blood cells is defined as
A. orythropoiesis
B. hematopoiesis
C. granulocytosis
D. myelopoiesis
B. hematopoiesis
If a patient has a prolonged prothrombin time (PT), the patient is most likely
deficient in factor:
A. III
B. IV
C. VII
D. IX
C. VII
Vasoconstriction, as an initial event in hemostasis, is caused by several regulatory
molecules which include:
A. fibrinogen and vWF
B. ADP and epinephrine
C. thromboxane A2 and serotonin
D. collagen and actin/myosin
C. thromboxane A2 and serotonin
Aspirin prevents platelet aggregation by inhibiting the action of:
A. PF 3
B. GpIb
C. thromboxane A2
D. GpIIbIIIa complex
C. thromboxane A2
The primary inhibitor of the fibrinolytic system is:
A. antiplasmin
B. protein S
C. antithrombin
D. protein C
A. antiplasmin
Which of the following is TRUE of platelet aggregation?
A. It is initiated at the site of an injury by conversion of fibrinogen to fibrin.
B. It is inhibited in uninjured blood vessels by prostacyclin of intact vascular
endothelium.
C. It causes morphological changes and release of the vasodilator serotonin.
D. It is inhibited by the release of ADP and thromboxane A2.
B. It is inhibited in uninjured blood vessels by prostacyclin of intact vascular
endothelium.
Approximately one-third of platelets are normally sequestered in the _________.
A. spleen
B. skin
C. lungs
D. kidneys
A. spleen
Which test is most useful for screening for coagulation disorders in the intrinsic
system?
A. Clotting time
B. Bleeding time
C. Activated Partial Thromboplastin Time
D. Prothrombin time
C. Activated Partial Thromboplastin Time
This test is most likely prolonged in defects from both intrinsic and extrinsic
coagulation
A. Capillary Fragility test
B. Bleeding time
C. Clotting time
D. Clot retraction time
C. Clotting time
A patient is currently on Heparin therapy. Which of the following tests is most useful
in monitoring this patient?
A. Bleeding time
B. Clotting time
C. Prothrombin time
D. APTT
D. APTT
What is the normal range value for APTT test?
A. 2-8 min
B. 10-15 min
C. 10-12 sec
D. 25-35 sec
D. 25-35 sec
Which of the factors will be activated when there is an exposure of the blood to
collagen from a traumatized blood vessel?
A. Factor XII
B. Factor XI
C. Factor X
D. Factor IX
A. Factor XII
Which of the following substances must be present in sufficient amounts to convert
prothrombin to thrombin after prothrombin activator has been formed as result of
rupture of a blood vessel?
A. Ionic sodium
B. Ionic calcium
C. Ionic potassium
D. Ionic Hydrogen
B. Ionic calcium
An increase of Total WBC count in the CBC is called:
A. Leukopenia
B. Anemia
C. Leukocytosis
D. Poikilocytosis
C. Leukocytosis
This cell is an agranular leukocyte:
A. Neutrophil
B. Basophil
C. Monocyte
D. Eosinophil
C. Monocyte
The daily production of white blood cells is:
A. 0.5 billion
B. 1 billion
C. 1.5 billion
D. 2 billion
C. 1.5 billion
