B3.035 - Hemolytic Anemias Prework 1 Flashcards
What does intrinsic hemolytic anemia mean
defect in RBC itself
What does extrinsic hemolytic anemia mean
defect/problem outside RBC but affects RBC
What does intravascular hemolytic anemia mean
RBC breakdown with massive release of free Hgb in circulation
What does extravascular hemolytic anemia mean
RBC breakdown in reticuloendothelial system cells (macrophages in spleen and liver) with capture of Hgb
What is extravascular hemolytic anemia usually caused by and does any Hgb get into circulation?
Decreased deformability of cell and yes
what causes reticulocytosis
anemia decreases RBC mass which stimulates kidney to release erythropoetin which stimulates bone marrow to increase amount of reticulocytes
In EH what are the reticulocyte count, EPO, polychromasia labs going to show
increased
In EH what happens to LDH
increased
In EH unconjugated bilirubin is
increased
In EH haptoglobin is
Decreased or normal
In EH serum free hemoglobin is
Absent
In EH urine hemoglobin is
Absent
In IH reticulocyte count, EPO, polychromasia is
increased
In IH LDH is
Increased
In IH unconjugated Hgb is
Increased
In IH haptogobin is
decreased
In IH serum free Hgb is
present
In IH urine Hgb is
present
What diseases have intrinsic etiology
Hemoglobinopathy - sickle cell
Thalassemia (microcytic) - alpha and beta
Membrane abnormality - heredetrary spherocytosis
RBC enzyme defects - G6P dehydrogenase deficiency
Paroxysmal nocturnal hemoglobinuria
What diseases have extrinsic etiology
Autoimmune hemolytic anemia
Traumatic hemolytic anemia
infections like malaria
when looking for hemolytic anemia what lap features would you look for
Reticulocytosis
anemia
blood smear morphology
Intravascular vs extravascular