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IBI Test 2 Leesy > B3.034 - Intro To RBC Disorders > Flashcards

B3.034 - Intro To RBC Disorders Flashcards

1
Q

What are nRBCs

A

Nucleated red blood cells

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2
Q

What are erythroblasts

A

7 day maturation time, preRBCs

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3
Q

What is erythropoeitin

A

Primary growth factor involved in erythropoeiesis

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4
Q

What do RBCs do

A

Transport oxygen

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5
Q

What are erythrocytes morphology

A

round, biconcave disk
central pallor
anucleate
eosinophilic cytoplasm

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6
Q

On a CBC what doe RBC tell you

A

total number

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7
Q

on a CBC what does Hgb tell you

A

total amount of hemoglobin

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8
Q

on a CBC what does Hct tell you

A

proportion of blood (by volume) occupied by RBCs

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9
Q

on a CBC what does MCV tell you

A

mean RBC volume/size

-cystic

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10
Q

On a CBC what does MCHC tell you

A

average amount of hemoglobin per RBC volume -chromic

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11
Q

on CBC what does RDW tell you

A

variation in RBC size

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12
Q

what 3 categories are defined by MCV

A

microcytic, normocytic, macrocytic

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13
Q

what 3 categories are defined by MCHC

A

hypochromic, normochromic, hyperchromic

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14
Q

what 3 categories are defined by RDW

A

anisocytosis
Poikilocytosis
Anisopoikilocytosis

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15
Q

what is anisocytosis

A

variation in size

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16
Q

what is poikilocytosis

A

variation of shape

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17
Q

what is anisopoikilocytosis

A

variation in size and shape

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18
Q

what are reticulocytes

A

immature RBCs containing residual RNA

aka polychormatophilic erythrocyte

19
Q

how long to reticulocytes survive

A

1 day before maturing

20
Q

what do reticulocyte levels correlated with

A

bone marrow erythropoietic activity

21
Q

how do you visualize reticulocytes

A

blood smear (wright stain)

22
Q

what are the practical measurements for anemia

A

Hgh, Hct, RBC

23
Q

what are general clinical features of anemia

A 
pallor of skin, nail beds
fatigue, weakness, malaise
Dyspnea on exertion
syncope, headache, visual disturbances
tachycardia
angina
cardiac failure
24
Q

what are two types of hypoproliferative anemia

A

inadequate or ineffective production

25
Q

What are types of inadequate production

A

bone marrow failure
bone marrow infiltration/replacement
nutritional deficiency
anemia of chronic disease

26
Q

what type of -cyitic is anemia of chronic disease

A

microcytic

27
Q

what type of -cytic is iron deficiency

A

micro

28
Q

what labs do you want for iron deficiency

A

iron
transferrin
ferritin

29
Q

what labs do you want for megaloblastic anemia and what type of -cytic is it

A

macrocytic

vitamin B12, folate

30
Q

what type of disease are caused by ineffective production

A

myelodysplastic syndromes (macrocytic)

31
Q

in anemia of blood loss what can cause sequestration

A

splenomegaly, hypersplenism

32
Q

acute anemia due to blood loss is what type of -cytic

A

normocytic

33
Q

what are diseases of intrinsic etiology

A 
hemoglobinopathy
thalassemia
membrane abnormality
RBC enzyme defects
paroxysmal nocturnal hemoglobinuria
34
Q

what disease is an example of hemogobinopathy and is it intrinsic or extrinsic

A

sickle cell disease

intrinsic

35
Q

what type of diseases are thalassemia disease and is it intrinsic or extrinsic, -cytic?

A

alpha and beta
intrinsic
microlytic

36
Q

what is a diseas due to RBC enzyme defects and is it intrinsic or extrinsic

A

G6PD deficiency

37
Q

what are diseases of extrinsic etiology

A

autoimmune hemolytic anemia
traumatic hemolytic anemia
infections

38
Q

what are sites of hemolysis

A

extravascular and intravascular

39
Q

what happens to reticulocyte count, EPO, and polychromasia in EH and IH

A

increased in both

40
Q

what happens to LDH in EH and IH

A

increased

41
Q

what happens to unconjugated bilirubin in EH and IH

A

increased

42
Q

what happens to haptoglobin in EH and IH

A

EH - decreased or normal

IH - decreased

43
Q

what happens to serum free hemoglobin in EH and IH

A

EH - absent

IH - present

44
Q

what happens in urine hemoglobin in EH and IH

A

EH - absent

IH - present

IBI Test 2 Leesy (13 decks)

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