Autophagy

Question 1

mTOR is for

Answer 1

cell growth, cell signalling, cell proliferation, cell survival

Question 2

when nutrients are present what happens to mTOR

Answer 2

mTOR activated

no autophagy

Question 3

ubiquitin protease pathway

Answer 3

for degradation of most intracellular proteins that are not aggregated

Question 4

lysosomal degradation (less common than ubiquitin)

Answer 4

degrades larger extracellular proteins

and targets KFERQ signal during starvation

Question 5

what 4 pathways lead to lysosomes

Answer 5

phagocytosis
pinocytosis
receptor mediated endocytosis
autophagy

Question 6

types of autophagy

Answer 6

• macro: inducible and Mtor dependant
• micro: constiuitive
• chaperone mediated (KFERQ)

Question 7

alpha synuclein forms lewy bodies

Answer 7

true

Question 8

LRRK2
DARDARIN
PINK1
PARKIN

Answer 8

LRRK2 encoded DARDARIN which is a kinase acting on RAB responsible for proper membrane traficcking
Normal conditions: PINK1 (on PARK6) accumulates on bad mitochondria, calls PARKIN (E3) which ubiquitinates the mitochondria causing mitophagy