Alzheimers disease

Question 1

AD symptoms

Answer 1

impaired short term memory

• ability to calculate, visuospatial skills, and idomotor apraxia
• level of alertness is impaired in severe dx
• no motor weakness

Question 2

signs of AD

Answer 2

marked atrophy of the cerebral cortex and loss of cortical and subcortical neurons (hippocampus and the neocortex)

Question 3

stages of AD

Answer 3

• presx stage: cortical amyloidization
• predementia: synaptic dysfunction, decreased dendritic arborization, MCI
• dementia: decreased number of neuronal cell bodies and axons

Question 4

pathological hallmarks of AD

hippocampus and associative areas

Answer 4

• senile plaques (extracellular) B amyloid

- neurofibrillary tangles (intracellular) hyperphosphorylation of tau protein

Question 5

ACHesterase inhibitors for AD

Answer 5

• donepezil
• rivastigmine
• galantamine