Antipsychotics Flashcards
2 cardinal features of psychosis are
loss of contact with reality
lack of integration of self
psychotic disorders have one or more of 5 abnormalitites
delusions hallucinations disorganised thinking negative symptoms grossly disorgansied or abnormal motor behavior
2 hit model schizophrenia
that exposure to 2 or more environmental insults in the prenatal or perinatal life have a strong increase in susceptability for schizo development
MHC role in the brain
for maintenance and plasticity of synaptic connections
which cytokines are increased in schizo
IL6, TNFA, IL1RA
neurodevelopmental model in schizo pts
reduced elaboration of inhibitory pathways
excessive pruning of excitatory pathways
reduced myelination
positive symptoms of schizophrenia
hallucinations
delusions
cognitive symptoms
impaired executive function
- impaired memory
- impaired language processing
negative symptoms of schizophrenia
affective blunting anhedonia alogia avolition attentional impairment
cocaine, amphetamines and L dopa can all
increase synaptic dopamine availability and therefore cause drug induced psychosis
the mesolimbic pathway is responsible for
in/decrease of dopamine?
(it sends projections from VTA to the nucleus accumbens)
is responsible for the positive symptoms of schizophrenia and correlate to an increase in dopamine firing
the mesocortical pathway is responsible for
(it sends projections from the VTA to the PFC)
is for the negative symptoms of schizophrenia due to a decrease in dopamine firing
nigrostriatal pathway projects from/to
from SNc to striatum (caudate/putamen)
antipsychotics are better at treating which type of schizo symptoms
positive
first gen antipsychotics and MOA
antagonist of D2
Haloperidol
Flupentixol
Chlorpromazine
