Autonomic regulation of airways Flashcards
Where is V/Q higher - base or apex
apex
what regulates smooth muscle tone
inflammation and autonomic nervous system
what does parasympathetic stimulation do to the lungs
bronchoconstrictor
describe the passage of the vagus nerve relative to airways
terminates in parasympathetic gamglia in airway walls
describe the role of vagus nerve on bronchoconstriction/ dilation
constriction;
post-synaptic fibres reach muscle, release ACh, acts on muscarinic receptors of M3 subtype to stimulate smooth muscle contraction
what neurotransmitter and receptor is involved in parasympathetic airway control
ACh, muscarinic receptor of M3 subtype
what do antimuscarinic drugs do
decrease bronchoconstriction
what do anticholinergic drugs do
bronchodilator
what do beta-2 antagonists do
increase bronchodilation
what does the sympathetic nervous system do for bronchoconstriction/ dilation
dilation; release noradrenaline, activates adrenergic receptors leading to relaxation of smooth muscle
what do nicotinic receptors respond to
ACh and nicotine
what can stimulate nicotinic receptors
sympathetic and mainly parasympathetic
where are nicotinic receptors found
post-ganglionic neurons and neuro-muscular junctions
what do nicotinic receptors contain
ligand-gated channel that is permeable to Na+ and K+
what nervous system are muscarinic receptors involved in
parasympathetic
