Autonomic NS- Adrenergic

Question 1

Direct acting catecholamines

Answer 1

Epinephrine
NE
Dopamine
Isoprenaline
Dobutamine

Question 2

Dobutamine Receptor preferance

Answer 2

B1 > B2&raquo_space;> a1

doBButAmine

Question 3

Epinephrine dose dependent effects

Answer 3

Low dose- B1, B2 agonist

High dose- a1 agonist

Question 4

Epinephrine indications

Answer 4

Cardiac arrest
Heart block
Anaphylactic shock
Hypotensive crisis
Acute asthma attack

Question 5

NE indications

Answer 5

Cardiac arrest
Heart block
Septic, Cardiogenic, Neurogenic shock
Hypotensive crisis

Question 6

Dopamine dose dependent effects

Answer 6

Low dose- D1 stimulation (Increased renal perfusion)
Medium dose- B1 stimulation
High dose- Acts like Epi

Question 7

Dopamine indication

Answer 7

Shock

With renal failure

Question 8

Isoprenaline Receptor preferance

Answer 8

B1=B2

Iso isl like equally =

Question 9

Dobutamine Receptor preferance

Answer 9

B1 > B2&raquo_space;> a1

Question 10

Dobutamine indication

Answer 10

Cardiogenic shock
Acute heart failure
Cardiac stimulation in cardiac stress test

Question 11

a- agonists

Receptor preferance

Answer 11

Phenylephrine- a1
Oxymetazoline- local a1, systemic a2
Clonidine- a2, I2
Rimenidine- a2, I2
Methyldopa- a2
Brimonidine- a2
Tizanidine- a2

All -dine suffix is for a2-R
Long words are for a1-R
You cant measure BMR on CT

Question 12

Clonidine indications

Answer 12

Antihypertensive
ADHD
Tourettes
Alcohol withdrawal synd.

Question 13

Which a-agonist is indicated locally in case of Glaucoma?

Which R?

Answer 13

a2-R

Brimonidine

Question 14

Which a-agonist is an orally taken muscle relaxant?

Which R?

Answer 14

a2-R

Tizanidine

Question 15

B2- agonists

Answer 15

Albuterol
Fenoterol
Terbutaline
Salmeterol
Formeterol

AFT and FOR SALE-meterol

Question 16

Albutarol is also called

Answer 16

Salbutamol

Question 17

Short acting B2 agonists

Answer 17

Albuterol
Fenoterol
Terbutaline

Question 18

Long acting B2 agonists

Answer 18

Salmeterol

Formoterol

Question 19

Besides Asthma treatment, give another indication for Terbutaline?

Answer 19

Suppress premature labor

Question 20

Indirect acting sympathomimetics can be 3 types

Answer 20

Release inducing
Reuptake inhibitors
MAO inhibitors

Question 21

Indirect acting sympathomimetics

Release inducing

Answer 21

Amphetamine
Methylphenidate
Tyramine
Ephedrine

TEAM players!! they help release more

Question 22

Indirect acting sympathomimetics
Reuptake inhibitors
+ MOA

Answer 22

Cocaine- NET+DAT inhibition
Atomoxetine- NE reuptake inhibition
Modafinil- NET+DAT inhibition

Question 23

Indirect acting sympathomimetics
MAO inhibitors
+ MOA

Answer 23

Tanylcypromine- Non selective, irreversible
Moclobemide- MAO A, reversible
Selegiline- MAO B, reversible

Question 24

Selegiline MOA+ indication

Answer 24

MAO B inhibition
Reversible
Parkinson

Question 25

Tanylcypromine, Moclobemide indication

Answer 25

Antidepressant | Tanylcypromine is not longer used

Question 26

Direct acting sympatholytics a antagonists Which R?

Answer 26

``` Phentolamine- Non selective Phenoxybenzamine- Non selective Prazosin- a1 Doxazosin- a1 Tamsulosin- a1 Urapidil- a1 antag, a2 agon, B antag, 5-HT agon Mitrazapine- a2 ```

Question 27

Direct acting sympatholytics | Only a1 antagonists

Answer 27

Prazosin Doxazosin Tamsulosin

Question 28

Direct acting sympatholytics | Non selective a antagonists

Answer 28

Phentolamine | Phenoxybenzamine

Question 29

Direct acting sympatholytics | a2 antagonist

Answer 29

Mitrazapine

Question 30

Prazosin Doxazosin Tamsulosin Indication

Answer 30

HTN | BPH -> relax muscle and allows urination

Question 31

Which a1 antagonist is used in PTSD?

Answer 31

Prazosin אתה צריך לקבל פרס אם אתה עוזר ל PTSD

Question 32

Non selective B-R antagonists

Answer 32

Propranolol Timolol Pindolol Sotalol Pls Tell People Sorry, we dont treat CHF

Question 33

Selective B-1 antagonists

Answer 33

``` Bisoprolol Acebutolol Nebivolol Esmolol Metoprolol ``` BANE-M Bane is the 1st bad guy in Batman

Question 34

Combined a and B antag | Which R?

Answer 34

Cervedilol Labetalol ללללא קקקקריטי להם איזה רצפטור Both B1, B2, a1 antagonists

Question 35

Which B blockers have the highest lipid solubility?

Answer 35

Propranolol Nebivilol Bisoprolol

Question 36

Indirect acting sympatholytics | Tyrosine hydroxilase inhibitor

Answer 36

Metyrosine

Question 37

Tyrosine hydroxilase- tell me about it

Answer 37

Rate limiting step in catecholamine synthesis | Dopamine, NE, Epi..

Question 38

Indirect acting sympatholytics | VMAT inhibitor

Answer 38

Reserpine רסרפין עוצר את הרזרבה