Brainscape's Knowledge GenomeTM


Top Flashcards (Certified)
All Flashcards

S.N Pharmacology I > A: 6-11 > Flashcards

A: 6-11 Flashcards

1
Q

What is the drug of choice if we want to replace Cortisol?

A

Hydrocortisone

כמו שצריך היידריישן אם חסר לך מים

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
2
Q

Which corticosteroid has a short duration of action?

A

Hydrocortisone
8-12 h

אתה כל הזמן צריך לשתות מים זה לא מספיק פעם אחת

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
3
Q

Which cortico. has intermediate duration of action?

A

Triamcinolone
Prednisolone
Methylprednisolone

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
4
Q

Which cortico. has a long DOA?

A

Dexamethasone

36-72 h

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
5
Q

Prednisolone and Methylprednisolone indications

A

Systemic anti-inflammatory and immunosuppressive effects

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
6
Q

Triamcinolone indication

A

Topical

T=T

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
7
Q

Which cortic. has an increased toxicity?

A

Triamcinolone

Toxic=T

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
8
Q

Dexamethasone indication

A

Antiinflammatory
Immunosuppressive
Used when water retention is undesirable

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
9
Q

How do cortico. present in the body?

A

90% bound to CBG

5-10% free form

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
10
Q

Cortico. metabolism

A

80% hepatic

20% renal

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
11
Q

Cortico. MOA (8)

A 
Lower Leuko. migration
Lower capillary permeability
PLA2 inhibitionn
Lower COX-2 expression
Lower PLT activator factor
Lower IL
Inhibits NF-kB
Apoptosis of Lymphocytes
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
12
Q

Glucocort. for topical use

A

Budesonide
Fluocinolone
Fluticasone
Mometasone

BFF Me!!!

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
13
Q

Topical glococort. indications

A 
Asthma
Dermatology
Allergic rhinitis
Conjunctvitis
Arthritis
IBD's
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
14
Q

Which drug blocks 11B-Hydroxylase?

A

Metyrapone

מתיר אפון

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
15
Q

Mineralocorticosteroids: (2)

+ Duration of action

A

Aldosterone 1-2 h

Fludrocortisone 8-12 h

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
16
Q

What is the drug of choice for replacement therapy of Aldosterone?

A

Fludrocortisone

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
17
Q

Mineralcort. side effects

A 
Slat and water retention
HTN
CHF
Cardiac remodeling
Glucocort. excess
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
18
Q

What are the synthestic analoges of Testosterone?

How to take?

A

Testosterone undecanoate- orally

Nandrolone- Parenteral

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
19
Q

What counts as an anabolic testosterone steroid?

A

Nandrolone

קצת כמו נאנדתרל

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
20
Q

Synthetic Testosterones indications

A

Hypogonadism in boys
Hormone replacement therapy
Stimulates RBC production in some anemias

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
21
Q

Female side effects of Testosterone?

A

Virilization

Menstrual irregularuty

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
22
Q

Male side effects of Testosterone

A

Feminization due to feedback mechanism

Prostate pathology

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
23
Q

Both sexes side effects of Testosterone

A

Cholesthatic jaundice
Increased liver enzymes
Hepatocellular carcinoma

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
24
Q

Testosterone contraindication

A

Pregnancy
Prostate cancer
CHF
Livr diseas ~

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
25
Antiandrogens can be divided into
Receptor inhibitiors: Bicalutamide 5a-reductase inhibitors: Finasteride GnRH agonist: Gosereline GnRH antagonists: Degarelix
26
Bicalutamibe MOA
Competative inhibitor of androgen receptor
27
Bicalutamibe indications (2)
Prostate cancer | Precocious puberty
28
Bicalutamibe side effects
Gynecomastia Flushes Impotence Hepatotoxicity
29
Which enzyme catalize the convertion of Testosterone into DHT
5a-reductase
30
Which drug is a 5a-reductase inhibitor?
Finasteride
31
Finasteride indications
BPH | Can prevent male baldness
32
GnRH agonist
Goserelin
33
What is the long term effect of Goserelin?
Suppression of gonadotropin secretion
34
Gosrerlin indication
Central precocious puberty | Prostate cancer
35
Degarelix MOA
GnRH antagonist
36
Drug that affect sexual activity
Sidenafil
37
Sidenafil MOA
PDE-5 inhibitor
38
PDE-5 job
breaks down cGMP --> Vasoconstriction
39
PDE-5 inhibitors MOA
cGMP increases --> Vasodilation
40
PDE-5 inhibitors route
Oral
41
Commercial name of Sildenafil
Viagra
42
Sildenafil indications
Erectile dysfunction Pulmonary HTN BPH
43
Give an example for synthetic Estrogen
Ethinyl-Estradiol
44
Ethinyl Estradiol metabolism
CYP 450
45
Ethinyl-Estradiol indications
Hypogonadism Hormone replacemnt thrapy Prevent bone loss Contraceptive
46
Which Estrogen drug can be given to treat menopause symp.?
Estradiol
47
Estrogen side effects | Moderate toxicity
Bleeding Nausea Breast tenderness
48
Estrogen side effects | Severe toxicity
``` Thromboembolism Gallbladder Hyper TG Migrane HTN Depression ```
49
Selective Estrogen Receptor Modulators (3)
Raloxifen Clomifen Tamoxifen R-CT
50
SERM- what is it selective for?
Antagonist at breast, CNS, uterus | Agonist at liver and bone
51
Tamoxifen indication
Hormone responsive breast cancer
52
Tamoxifen side effects
Hot flushes Thromboembolism Endometrial hyperplasia
53
Raloxifene indications
Prevention of osteoporosis in postmena.
54
Clomifene indications
Ovulation induction
55
SERM drugs are given through
Oral
56
Clomifene MOA
Selective inhibition of Estrogen-R in pituitary --> Reduced NF --> Induce LH/FSH secretion
57
Aromatase inhibitor
Anastrozole אנס את הארומטייז
58
Anastrozole indications
Adjuvent treatment of hormone responsive breast cancer אנס את הסרטן
59
Anastrozole side effects
Flushes MSK Bone density down Joint symp.
60
What is Gosereline MOA?
Synthetic peptide with GnRH agonist activity
61
Goserelin indications in females
Overian suppression in Endometriosis and Leiomyoma | Central precocious puberty
62
Degarelix MOA
GnRH antag.
63
Degarelix female indication
Controlled ovarian stimulation
64
Describe Progestin
Induce secretory change in the endometrium Breast proliferation Maintenance of pregnancy Metabolic effect
65
Synthestic Progestrones (6)
``` Cyproterone acetate- ציפור טרון Drospirenon- דרור ספיר Desogestrel Levonorgestrel Medroxyprogesterone Norethisterone- הציפורים עפות צפונה ```
66
Synthestic Progesterone indications
``` Hormone replacement Contraceptive Infertility Prevent Estrogen induced endometrial cancer Promote and maintain pregnancy ```
67
Synth. Progest. metabolism
CYP 450
68
Progestins side effects (6)
``` Lowers HDL Increases LDL HTN Weight gain Decreases bone density Increases breast cancer risk ```
69
Anti Progestins
Mifepristone Ulipristal acetate UMMM i dont want to be pregnant מי פה הפריסט? אולי הפריסט יעשה לי הפלה?
70
Mifepristone MOA
Progestin and Glucocort. R antagonist
71
Mifepristone indications
Meidcal abortion up to 49 days after last menstrual
72
Mifepristone side effects
GI Vaginal bleeding Atypical infections
73
Ulipristal acetate MOA
SPRM
74
Ulipristal acetate indications
Emergancy birth pill | Myoma growth suppression
75
Hormonal contraceptive- preparation available (6)
``` Pill Injection: 8 weeks SC implants: 3-6 years Transdermal patch: 1 week Vaginal ring: 3 weeks IUD: 5 years ```
76
Types of preparation used for oral contraceptive (2)
Combination of Estrogen and Preogestin | Contineous Progesterin therapy without Estrogen
77
Biphasic contraceptive which are the agents?
Ethinyl-Estradiol (Always) | Levonorgestrel or Desogestrel
78
Oral contraceptive MOA
Combination ov Estrogen and Progestin selectively inhibits the pituitary from releasing LH/FSH so no LH surge and no ovulation
79
Mild oral contraceptive side effects (5)
``` GI Edema Endocrine Headache Withdrawal bleeding ```
80
Moderate oral contraceptive side effects (7)
``` Weight gain Skin pigmentation Acne Hirsutism Ureteral dilation Vaginal infections Amenorrhea ```
81
Severe oral contraceptive side effects
Thromboembolism GI Depression
82
Oral contraceptive contraindiccation
``` Recurrent thromboembolic/cardiovascular events Estrogen neoplasms Vaginal bleeding Prior to epiphyseal closure Smoking ```
83
Emergency contreceptive contains
High dose Progesterin- Levonorgestrel | Or Ulipristal acetate
84
Progesterone derivative that is more resistant to metabolism for improved pharmacokinetic properties
Medroxyprogesterone-acetate MPA

S.N Pharmacology I (15 decks)

Brainscape helps you reach your goals faster, through stronger study habits.
© 2025 Bold Learning Solutions. Terms and Conditions