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Pharmacology > Autonomic Nervous System Drugs > Flashcards

Autonomic Nervous System Drugs Flashcards

1
Q

PNS: Indirect Reversible Agonists

A

Neostygmine Pyridostigmine Edrophonium Rivastigmine

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2
Q

PNS: Indirect Irreversible Agonists

A

Malathion

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3
Q

PNS: Direct Reversible Agonists

A

Bethanecol Pilocarpine - muscarinic receptors

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4
Q

PNS: Stimulation of Eye Receptors

A

Miosis Contraction of Ciliary Muscle Accommodation Aqueous Humour Outflow

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5
Q

PNS: Stimulation of GIT Receptors

A

Contract muscle Relax sphincters Increase secretions

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6
Q

PNS: Stimulation of Bladder Receptors

A

Contract muscle Relax sphincter

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7
Q

PNS: Stimulation of CVS Receptors

A

Inhibit AV/SA node Decreased metabolism

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8
Q

PNS: Stimulation of Resp Receptors

A

Broncho-constriction Mucous secretion

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9
Q

PNS: Therapeutic Use - Pilocarpine

A

Eye (glaucoma) - aqueous humour outflow lowers intraocular pressure

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10
Q

PNS: Therapeutic Use - Neostigmine

A

GIT Poisoning Bladder

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11
Q

PNS: MOA Indirect Reversible Agonists

A

Increase Ach levels by inhibiting AchE

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12
Q

PNS: MOA Indirect Irreversible Agonists

A

Increase Ach levels by inhibiting AchE permanently

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13
Q

PNS: MOA - Pilocarpine

A

Stimulates muscarinic receptors

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14
Q

PNS: Therapeutic Use - Edrophonium

A

CVS (Terminate SVT) Myasthenia gravis Bladder voiding

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15
Q

PNS: Therapeutic Use - Rivastigmine

A

Alzheimers (also Donepezil)

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16
Q

PNS: Direct Reversible Antagonists

A

Atropine Hyoscine Ipratropium bromide

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17
Q

PNS: MOA - Atropine

A

Blocks post ganglionic muscarinic receptors

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18
Q

PNS: MOA- Hyoscine

A

Blocks post ganglionic muscarinic receptors

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19
Q

PNS: Therapeutic Uses - Atropine

A

Mydriasis Dry secretions (presurgery) Pesticide poisoning Stop vagal induced effects

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20
Q

PNS: Therapeutic Uses - Ipratropium Bromide

A

Bronchodilator Decreases mucous secretions

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21
Q

PNS: Therapeutic Uses - Hyoscine

A

Decreases gastric motility Dry secretions (presurgery) Treat IBS

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22
Q

PNS: Therapeutic Uses – Amitriptyline

A

Enuresis

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23
Q

PNS: Agonist Adverse Effects

A

Asthma Diarrhoea Salivation Bradycardia

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24
Q

PNS: Antagonist Adverse Effects

A

Dry mouth Tachycardia Constipation Urine retention Blurred vision Mydriasis Glaucoma (increased intraocular pressure)

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25
Q

SNS: Stimulation of α1 receptors

A

Vasoconstriction (increased TPR) ∴ Increase BP

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26
Q

SNS: Stimulation of α2 receptors

A

Inhibit presynaptic NA Decrease insulin release

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27
Q

SNS: Stimulation of β1 receptors

A

Increase HR (↑ conduction in SA/AV nodes) Increase heart contractility (↑ Ca2+ ↑cAMP) Renin release

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28
Q

SNS: Stimulation of β2 receptors

A

Relax/dilate: 1. Bronchi 2. Blood vessels of heart 3. Pregnant uterus Decrease liver glucose

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29
Q

SNS: α1 receptor pure agonists

A

Phenylephirine Oxymetazoline

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30
Q

SNS: α2 receptor pure agonists

A

α-methyl-dopa

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31
Q

SNS: β1 receptor pure agonists

A

Dobutamine Dopamine (locus cerulleus)

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32
Q

SNS: β2 receptor pure agonists

A

Salbutamol Salmeterol Hexoprenaline

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33
Q

SNS: α-methyl-dopa MOA

A

Convert to α-methylonoradrenaline Reduce central SNS output and TPR

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34
Q

SNS: Therapeutic Uses - Salbutamol

A

Asthma COPD Stops premature labour

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35
Q

SNS: Therapeutic Uses - Dopamine

A

Increase HR and CO Cardiogenic shock Ventricular Fibrillation Heart Failure

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36
Q

SNS: Therapeutic Uses - Adrenaline

A

Anaphylaxis treatment Increase HR and CO Lung bronchodilation Increased blood flow in skeletal blood vessels

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37
Q

SNS: Therapeutic Uses - Phenylephidrine

A

Decongestant of nose & eye Allergy rhinitis

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38
Q

SNS: β2 agonists - MOA

A

Mimics action of adrenalin on receptors Increases cAMP levels in smooth muscle causing relaxation

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39
Q

SNS: β1 agonists - MOA

A

↑ Ca2+ ↑cAMP levels in heart Increases conduction in SA/AV nodes Increases contractility Increases O2 demand in heart Increases renal perfusion

40
Q

SNS: α1 agonists - MOA

A

Mimics action of NA and A on receptors Increase α1 activity

41
Q

SNS: Therapeutic Uses - α-methyl-dopa

A

Acts on locus coeruleus Treats hypertension

42
Q

SNS: Sympathomimetics

A

Cocaine Amphetamine Ephedrine

43
Q

SNS: Cocaine - MOA

A

Acts in synaptic cleft NT re-uptake inhibitor

44
Q

SNS: Ephidrine - MOA

A

Acts in synaptic cleft Enter synaptic vessel and causes release of NTs Weak response

45
Q

SNS: Amphetamine - MOA

A

Acts in synaptic cleft Enter synaptic vessel and causes massive release of NTs Potent response

46
Q

SNS: Ephidrine - Therapeutic Use

A

Weak oral decongestant

47
Q

SNS: α1 receptor pure antagonists

A

Alfuzosin Doxazosin

48
Q

SNS: α1 and α2 receptor antagonists

A

Phentolamine Phentolamine

49
Q

SNS: β1 and β2 receptor antagonists

A

Propanolol

50
Q

SNS: β1 receptor pure antagonists

A

Atenolol

51
Q

SNS: α1, β1 & β2 receptor antagonists

A

Carvedilol

52
Q

SNS: Therapeutic Use - Atenolol

A

Angina Arrhythmia MI

53
Q

SNS: Therapeutic Use - Propanolol

A

Anxiety Migrane

54
Q

SNS: Therapeutic Use - Carvedilol

A

Heart Failure

55
Q

SNS: Therapeutic Use - Doxazosin

A

Hypertension BPH treatment ( Vasodilation and sphincter relaxes)

56
Q

SNS: β1 receptor pure antagonists - MOA

A

Block action of NA in heart specifically therefore increasing PSNS action

57
Q

SNS: β1 and β2 receptor antagonists - MOA

A

Block action of NA in heart and lungs therefore increasing PSNS action

58
Q

Neostygmine Pyridostigmine Edrophonium Rivastigmine

A

PNS: Indirect Reversible Agonists

59
Q

Malathion

A

PNS: Indirect Irreversible Agonists

60
Q

Bethanecol Pilocarpine - muscarinic receptors

A

PNS: Direct Reversible Agonists

61
Q

Eye (glaucoma) - aqueous humour outflow lowers intraocular pressure

A

PNS: Therapeutic Use - Pilocarpine

62
Q

GIT Poisoning Bladder

A

PNS: Therapeutic Use - Neostigmine

63
Q

Increase Ach levels by inhibiting AchE

A

PNS: MOA Indirect Reversible Agonists

64
Q

Increase Ach levels by inhibiting AchE permanently

A

PNS: MOA Indirect Irreversible Agonists

65
Q

Stimulates muscarinic receptors

A

PNS: MOA - Pilocarpine

66
Q

CVS (Terminate SVT) Myasthenia gravis Bladder voiding

A

PNS: Therapeutic Use - Edrophonium

67
Q

Alzheimers (also Donepezil)

A

PNS: Therapeutic Use - Rivastigmine

68
Q

Atropine Hyoscine Ipratropium bromide

A

PNS: Direct Reversible Antagonists

69
Q

Blocks post ganglionic muscarinic receptors

A

PNS: MOA - Atropine

70
Q

Blocks post ganglionic muscarinic receptors

A

PNS: MOA- Hyoscine

71
Q

Mydriasis Dry secretions (presurgery) Pesticide poisoning Stop vagal induced effects

A

PNS: Therapeutic Uses - Atropine

72
Q

Bronchodilator Decreases mucous secretions

A

PNS: Therapeutic Uses - Ipratropium Bromide

73
Q

Decreases gastric motility Dry secretions (presurgery) Treat IBS

A

PNS: Therapeutic Uses - Hyoscine

74
Q

Enuresis

A

PNS: Therapeutic Uses – Amitriptyline

75
Q

Asthma Diarrhoea Salivation Bradycardia

A

PNS: Agonist Adverse Effects

76
Q

Dry mouth Tachycardia Constipation Urine retention Blurred vision Mydriasis Glaucoma (increased intraocular pressure)

A

PNS: Antagonist Adverse Effects

77
Q

Phenylephirine Oxymetazoline

A

SNS: α1 receptor pure agonists

78
Q

α-methyl-dopa

A

SNS: α2 receptor pure agonists

79
Q

Dobutamine Dopamine (locus cerulleus)

A

SNS: β1 receptor pure agonists

80
Q

Salbutamol Salmeterol Hexoprenaline

A

SNS: β2 receptor pure agonists

81
Q

Convert to α-methylonoradrenaline Reduce central SNS output and TPR

A

SNS: α-methyl-dopa MOA

82
Q

Asthma COPD Stops premature labour

A

SNS: Therapeutic Uses - Salbutamol

83
Q

Increase HR and CO Cardiogenic shock Ventricular Fibrillation Heart Failure

A

SNS: Therapeutic Uses - Dopamine

84
Q

Anaphylaxis treatment Increase HR and CO Lung bronchodilation Increased blood flow in skeletal blood vessels

A

SNS: Therapeutic Uses - Adrenaline

85
Q

Decongestant of nose & eye Allergy rhinitis

A

SNS: Therapeutic Uses - Phenylephidrine

86
Q

Acts on locus coeruleus Treats hypertension

A

SNS: Therapeutic Uses - α-methyl-dopa

87
Q

Cocaine Amphetamine Ephedrine

A

SNS: Sympathomimetics

88
Q

Weak oral decongestant

A

SNS: Ephidrine - Therapeutic Use

89
Q

Alfuzosin Doxazosin

A

SNS: α1 receptor pure antagonists

90
Q

Phentolamine Phentolamine

A

SNS: α1 and α2 receptor antagonists

91
Q

Propanolol

A

SNS: β1 and β2 receptor antagonists

92
Q

Atenolol

A

SNS: β1 receptor pure antagonists

93
Q

Carvedilol

A

SNS: α1, β1 & β2 receptor antagonists

94
Q

Angina Arrhythmia MI

A

SNS: Therapeutic Use - Atenolol

95
Q

Anxiety Migrane

A

SNS: Therapeutic Use - Propanolol

96
Q

Heart Failure

A

SNS: Therapeutic Use - Carvedilol

97
Q

Hypertension BPH treatment ( Vasodilation and sphincter relaxes)

A

SNS: Therapeutic Use - Doxazosin

Pharmacology (6 decks)

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