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Autonomic Nervous System Drugs Flashcards

1
Q

PNS: Indirect Reversible Agonists

A

Neostygmine Pyridostigmine Edrophonium Rivastigmine

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2
Q

PNS: Indirect Irreversible Agonists

A

Malathion

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3
Q

PNS: Direct Reversible Agonists

A

Bethanecol Pilocarpine - muscarinic receptors

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4
Q

PNS: Stimulation of Eye Receptors

A

Miosis Contraction of Ciliary Muscle Accommodation Aqueous Humour Outflow

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5
Q

PNS: Stimulation of GIT Receptors

A

Contract muscle Relax sphincters Increase secretions

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6
Q

PNS: Stimulation of Bladder Receptors

A

Contract muscle Relax sphincter

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7
Q

PNS: Stimulation of CVS Receptors

A

Inhibit AV/SA node Decreased metabolism

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8
Q

PNS: Stimulation of Resp Receptors

A

Broncho-constriction Mucous secretion

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9
Q

PNS: Therapeutic Use - Pilocarpine

A

Eye (glaucoma) - aqueous humour outflow lowers intraocular pressure

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10
Q

PNS: Therapeutic Use - Neostigmine

A

GIT Poisoning Bladder

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11
Q

PNS: MOA Indirect Reversible Agonists

A

Increase Ach levels by inhibiting AchE

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12
Q

PNS: MOA Indirect Irreversible Agonists

A

Increase Ach levels by inhibiting AchE permanently

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13
Q

PNS: MOA - Pilocarpine

A

Stimulates muscarinic receptors

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14
Q

PNS: Therapeutic Use - Edrophonium

A

CVS (Terminate SVT) Myasthenia gravis Bladder voiding

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15
Q

PNS: Therapeutic Use - Rivastigmine

A

Alzheimers (also Donepezil)

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16
Q

PNS: Direct Reversible Antagonists

A

Atropine Hyoscine Ipratropium bromide

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17
Q

PNS: MOA - Atropine

A

Blocks post ganglionic muscarinic receptors

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18
Q

PNS: MOA- Hyoscine

A

Blocks post ganglionic muscarinic receptors

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19
Q

PNS: Therapeutic Uses - Atropine

A

Mydriasis Dry secretions (presurgery) Pesticide poisoning Stop vagal induced effects

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20
Q

PNS: Therapeutic Uses - Ipratropium Bromide

A

Bronchodilator Decreases mucous secretions

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21
Q

PNS: Therapeutic Uses - Hyoscine

A

Decreases gastric motility Dry secretions (presurgery) Treat IBS

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22
Q

PNS: Therapeutic Uses – Amitriptyline

A

Enuresis

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23
Q

PNS: Agonist Adverse Effects

A

Asthma Diarrhoea Salivation Bradycardia

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24
Q

PNS: Antagonist Adverse Effects

A

Dry mouth Tachycardia Constipation Urine retention Blurred vision Mydriasis Glaucoma (increased intraocular pressure)

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25
SNS: Stimulation of α1 receptors
Vasoconstriction (increased TPR) ∴ Increase BP
26
SNS: Stimulation of α2 receptors
Inhibit presynaptic NA Decrease insulin release
27
SNS: Stimulation of β1 receptors
Increase HR (↑ conduction in SA/AV nodes) Increase heart contractility (↑ Ca2+ ↑cAMP) Renin release
28
SNS: Stimulation of β2 receptors
Relax/dilate: 1. Bronchi 2. Blood vessels of heart 3. Pregnant uterus Decrease liver glucose
29
SNS: α1 receptor pure agonists
Phenylephirine Oxymetazoline
30
SNS: α2 receptor pure agonists
α-methyl-dopa
31
SNS: β1 receptor pure agonists
Dobutamine Dopamine (locus cerulleus)
32
SNS: β2 receptor pure agonists
Salbutamol Salmeterol Hexoprenaline
33
SNS: α-methyl-dopa MOA
Convert to α-methylonoradrenaline Reduce central SNS output and TPR
34
SNS: Therapeutic Uses - Salbutamol
Asthma COPD Stops premature labour
35
SNS: Therapeutic Uses - Dopamine
Increase HR and CO Cardiogenic shock Ventricular Fibrillation Heart Failure
36
SNS: Therapeutic Uses - Adrenaline
Anaphylaxis treatment Increase HR and CO Lung bronchodilation Increased blood flow in skeletal blood vessels
37
SNS: Therapeutic Uses - Phenylephidrine
Decongestant of nose & eye Allergy rhinitis
38
SNS: β2 agonists - MOA
Mimics action of adrenalin on receptors Increases cAMP levels in smooth muscle causing relaxation
39
SNS: β1 agonists - MOA
↑ Ca2+ ↑cAMP levels in heart Increases conduction in SA/AV nodes Increases contractility Increases O2 demand in heart Increases renal perfusion
40
SNS: α1 agonists - MOA
Mimics action of NA and A on receptors Increase α1 activity
41
SNS: Therapeutic Uses - α-methyl-dopa
Acts on locus coeruleus Treats hypertension
42
SNS: Sympathomimetics
Cocaine Amphetamine Ephedrine
43
SNS: Cocaine - MOA
Acts in synaptic cleft NT re-uptake inhibitor
44
SNS: Ephidrine - MOA
Acts in synaptic cleft Enter synaptic vessel and causes release of NTs Weak response
45
SNS: Amphetamine - MOA
Acts in synaptic cleft Enter synaptic vessel and causes massive release of NTs Potent response
46
SNS: Ephidrine - Therapeutic Use
Weak oral decongestant
47
SNS: α1 receptor pure antagonists
Alfuzosin Doxazosin
48
SNS: α1 and α2 receptor antagonists
Phentolamine Phentolamine
49
SNS: β1 and β2 receptor antagonists
Propanolol
50
SNS: β1 receptor pure antagonists
Atenolol
51
SNS: α1, β1 & β2 receptor antagonists
Carvedilol
52
SNS: Therapeutic Use - Atenolol
Angina Arrhythmia MI
53
SNS: Therapeutic Use - Propanolol
Anxiety Migrane
54
SNS: Therapeutic Use - Carvedilol
Heart Failure
55
SNS: Therapeutic Use - Doxazosin
Hypertension BPH treatment ( Vasodilation and sphincter relaxes)
56
SNS: β1 receptor pure antagonists - MOA
Block action of NA in heart specifically therefore increasing PSNS action
57
SNS: β1 and β2 receptor antagonists - MOA
Block action of NA in heart and lungs therefore increasing PSNS action
58
Neostygmine Pyridostigmine Edrophonium Rivastigmine
PNS: Indirect Reversible Agonists
59
Malathion
PNS: Indirect Irreversible Agonists
60
Bethanecol Pilocarpine - muscarinic receptors
PNS: Direct Reversible Agonists
61
Eye (glaucoma) - aqueous humour outflow lowers intraocular pressure
PNS: Therapeutic Use - Pilocarpine
62
GIT Poisoning Bladder
PNS: Therapeutic Use - Neostigmine
63
Increase Ach levels by inhibiting AchE
PNS: MOA Indirect Reversible Agonists
64
Increase Ach levels by inhibiting AchE permanently
PNS: MOA Indirect Irreversible Agonists
65
Stimulates muscarinic receptors
PNS: MOA - Pilocarpine
66
CVS (Terminate SVT) Myasthenia gravis Bladder voiding
PNS: Therapeutic Use - Edrophonium
67
Alzheimers (also Donepezil)
PNS: Therapeutic Use - Rivastigmine
68
Atropine Hyoscine Ipratropium bromide
PNS: Direct Reversible Antagonists
69
Blocks post ganglionic muscarinic receptors
PNS: MOA - Atropine
70
Blocks post ganglionic muscarinic receptors
PNS: MOA- Hyoscine
71
Mydriasis Dry secretions (presurgery) Pesticide poisoning Stop vagal induced effects
PNS: Therapeutic Uses - Atropine
72
Bronchodilator Decreases mucous secretions
PNS: Therapeutic Uses - Ipratropium Bromide
73
Decreases gastric motility Dry secretions (presurgery) Treat IBS
PNS: Therapeutic Uses - Hyoscine
74
Enuresis
PNS: Therapeutic Uses -- Amitriptyline
75
Asthma Diarrhoea Salivation Bradycardia
PNS: Agonist Adverse Effects
76
Dry mouth Tachycardia Constipation Urine retention Blurred vision Mydriasis Glaucoma (increased intraocular pressure)
PNS: Antagonist Adverse Effects
77
Phenylephirine Oxymetazoline
SNS: α1 receptor pure agonists
78
α-methyl-dopa
SNS: α2 receptor pure agonists
79
Dobutamine Dopamine (locus cerulleus)
SNS: β1 receptor pure agonists
80
Salbutamol Salmeterol Hexoprenaline
SNS: β2 receptor pure agonists
81
Convert to α-methylonoradrenaline Reduce central SNS output and TPR
SNS: α-methyl-dopa MOA
82
Asthma COPD Stops premature labour
SNS: Therapeutic Uses - Salbutamol
83
Increase HR and CO Cardiogenic shock Ventricular Fibrillation Heart Failure
SNS: Therapeutic Uses - Dopamine
84
Anaphylaxis treatment Increase HR and CO Lung bronchodilation Increased blood flow in skeletal blood vessels
SNS: Therapeutic Uses - Adrenaline
85
Decongestant of nose & eye Allergy rhinitis
SNS: Therapeutic Uses - Phenylephidrine
86
Acts on locus coeruleus Treats hypertension
SNS: Therapeutic Uses - α-methyl-dopa
87
Cocaine Amphetamine Ephedrine
SNS: Sympathomimetics
88
Weak oral decongestant
SNS: Ephidrine - Therapeutic Use
89
Alfuzosin Doxazosin
SNS: α1 receptor pure antagonists
90
Phentolamine Phentolamine
SNS: α1 and α2 receptor antagonists
91
Propanolol
SNS: β1 and β2 receptor antagonists
92
Atenolol
SNS: β1 receptor pure antagonists
93
Carvedilol
SNS: α1, β1 & β2 receptor antagonists
94
Angina Arrhythmia MI
SNS: Therapeutic Use - Atenolol
95
Anxiety Migrane
SNS: Therapeutic Use - Propanolol
96
Heart Failure
SNS: Therapeutic Use - Carvedilol
97
Hypertension BPH treatment ( Vasodilation and sphincter relaxes)
SNS: Therapeutic Use - Doxazosin

Pharmacology (6 decks)

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