Autonomic Nervous System Flashcards
Outputs of the autonomic nervous system
Parasympathetic- cranial and sacral outflow
Sympathetic- adrenal amplification
Enteric nervous system
Function of sympathetic nervous system on heart
Increases heart rate
Increases force of contractiom
Function of sympathetic nervous system on blood vessels
Constriction
Function of sympathetic nervous system on lungs
Bronchodilation
Function of sympathetic nervous system on GI
decreased motility
Sphincter contraction
Decreased secretion
Function of parasympathetic nervous system on heart
Decreases heart rate
Decreases force of contraction
Function of parasympathetic nervous system on blood vessels
Vasodilation
Function of parasympathetic nervous system on lungs
Bronchoconstriction
Function of parasympathetic nervous system on GI
Increases motility
Sphincter relaxation
Increased secretions
When do autonomic fibres synapse
Fibres synapse once at a ganglion after the leave the CNS (2-neuron chain)
Motor control
When do somatic fibres synapse
Fibres do not synapse after they leave the CNS (single neuron from CNS to effector organ)
What does the somatic system innervate
Innervates skeletal muscle fibres, always stimulatory
What does the autonomic system innervate
Innervates smooth muscle , cardiac muscle and glands
Either stimulates or inhibits
Sacral outflow of parasympathetic
S1-S2
Parasympathetic in simple terms
Cranial nerves to head, thorax and neck
Sacral outflow to pelvic organs
Sympathetic in simple terms
Cranial nerves to eye
Sympathetic chain
- splanchnic nerves
Other ganglia
Post ganglionic fibres
Autonomic motor neuron
Preganglionic neuron= myelinated
Autonomic ganglion (ACh)
Postganglionic neuron= unmyelinated
Effectors (ACh or noradrenaline)
Functions of autonomic nervous system
Thermoregulation
Exercise
Digestion
Competition
Sexual function
Which cranial nerves contain parasympathetic fibres
3, 7, 9, 10
Sympathetic anatomy
White and grey rami communicates- sympathetic chain (T1-L2)
Splanchnic nerves to large thoraco-abdominal plexi
Sympathetic chain runs from
T1-L2
Function of enteric nervous system
Regulates intrinsic reflexes and integrative neural activity for motility, secretion, sensation and other key functions in the gut
There are intrinsic reflex circuits in the gut, dependent on coordinated serotonin signalling (5-HT)
Sympathetic receptor sub types - noradrenaline
Alpha : Alpha 1 and Alpha 2
Beta : beta 1,2,3
Which receptor type causes vasoconstriction of blood vessels
Alpha 1
Alpha 2
Which receptor type causes vasodilation of blood vessels
Beta 2
Which receptor type causes tachycardia and increased contractility
Beta 1
Which receptor type causes increased contractility of heart
Alpha 1
Which receptor type causes relaxation of bronchi
Beta 2
Which receptor type causes aggregation of thrombocytes
Alpha 2
Which receptor type causes vasoconstriction in kidneys
Alpha 1
Alpha 2
Which receptor type causes renin release and inhibition tubular sodium reabsorption
Beta 1
Beta 2
Which receptor type causes inhibition of lipolysis in adipocytes
Alpha 2
Which receptor type causes lipolysis in adipocytes
Beta 1,2,3
Acute primary ANS disorders
Pan-dysautonomia with neurological features
Chronic primary ANS disorders
Pure autonomic failure
Multiple system atrophy (Shy-Drager syndrome)
Autonomic failure with Parkinson’s disease
Name of receptor between preganglionic neurons and ganglion for ACh
Nicotinic receptor
Name of receptor following sympathetic postganglionic neuron
Adrenergic
Name of receptor following parasympathetic postganglionic neuron
Muscarinic receptor
Which receptor is common to both the sympathetic and parasympathetic nervous systems
Nicotinic receptors - preganglionic—->ganglion
Metabolic secondary ANS disorders
Diabetes mellitus
Chronic renal failure
Chronic liver disease
Alcohol induced
Inflammatory secondary ANS disorders
Guilliain-Barre syndrome
Infections secondary ANS disorders
Bacterial: tetanus
Parasitic: Chagas’ disease
Viral: HIV
Neoplasia secondary ANS disorders
Brain tumours (especially of 3rd ventricle or posterior fossa)
Main brainstem nuclei involved with cardiovascular system
Nucleus tractus solitarius
Nucleus ambiguus
Dorsal vagal nucleus
Main symptoms of primary ANS disorders
Fainting - cannot raise blood pressure when standing (postural hypotension)
Non-cardiovascular ANS measurement
Pupillometry
Sweat measurement
Skin blood flow, thermoregulation
Gastric acid secretion
Sexual function
Cardiovascular disorders
Postural hypotension
Supine hypertension
Lability of blood pressure
Paroxysmal hypertension
Tachycardia
Bradycardia
Sexual ANS disorders
Erectile failure
Ejaculatory failure
Retrograde ejaculation
Priapism
Sudomotor ANS disorders
Hypo- or anhidrosis
Hyperhidrosis
Gustatory sweating
Hypothermia
Hyperpyrexia
Heat intolerance
Alimentary ANS disorders
Gastric stasis
Dumping syndromes
Constipation
Diarrhoea
ANS disorders of the eye
Pupillary abnormalities
Ptosis
Alachryma
Abnormal lacrimation with food ingestion
Measuring cardiovascular function
Heart rate and blood pressure beat by beat
How to test blood pressure
Head-up Tilt table test
Intra-arterial needle in radial artery
Baro-reflex testing by phenylephrine test- baroreflex sensitivity (invasive)
Baroreflex testing by ambulatory recording (non-invasive)
Baro-reflex testing- By Phenylephrine test
Measure R-R interval after iv pressor agent Phenylephrine- (PE)
Phenylephrine is a
Vasoconstrictor