Autoimmunity Flashcards
What are seropositive conditions?
Conditions that produce auto-antibodies
What are the factors that contribute to the loss of regulation of auto-antibodies?
genetic predisposition and several environmental insults such as infection or prolonged chemical exposure
What is the associated condition with the antibody Anti-CCP ?
Rheumatoid arthritis
What is the associated condition with the antibody anti-nuclear antibody (ANA)?
SLE, Sjogren’s syndrome, Systemic Sclerosis, MCTD, autoimmune liver disease
What is the associated condition with the antibody anti-double stranded DNA antibody (dsDNA)?
SLE
What is the associated condition with the antibody anti-Sm?
SLE
What is the associated condition with the antibody Anti-Ro?
SLE, Sjogren’s syndrome
What is the associated condition with the antibody Anti-La?
Sjogren’s syndrome
What is the associated condition with the antibody Anti-centromere?
Systemic sclerosis
What is the associated condition with the antibody anti-Scl-70?
systemic sclerosis
What is the associated condition with the antibody anti-RNP antibody?
SLE, mixed connective tissue disease
What is the associated condition with the antibody anti-Jo-1?
myositis
What is the associated condition with the antibody anti-cardiolipin and lupus anti-coagulant?
anti-phospholipid syndrome
What is the associated condition with the antibody anti-neutrophil cytoplasmic (ANCA)?
small vessel vasculitis (GPA, EGPA, MPA)