autoimmunity

Question 1

epitope spreading

Answer 1

a

Question 2

molecular mimicry

Answer 2

a

Question 3

autoimmune hemolytic anemia

Answer 3

antibodies produced against own RBCs

Question 4

goodpasture’s syndrome

Answer 4

autoantibodies against one chain of type IV collagen

Question 5

pernicious anemia

Answer 5

autoantibodies against IF or gastric parietal cells

Question 6

hashimoto’s thyroiditis

Answer 6

autoantibodies and autoreactive T cells against thyroid gland proteins

Question 7

idiopathic thrombocytopenia purpura

Answer 7

autoantibodies to platelet membrane proteins

Question 8

grave’s disease

Answer 8

autoantibodies against TSH receptors

Question 9

vitiligo

Answer 9

autoimmune destruction of melanocytes

Question 10

myasthenia gravis

Answer 10

autoantibodies against ACh receptors

Question 11

DM

Answer 11

immune-mediated destruction of insulin-secreting B cells in pancreas

Question 12

MS

Answer 12

demyelination of CNS via oligodendrocytes

TH1 and TH17 cells specific for myelin antigens

Question 13

SLE

Answer 13

constellation of autoantibodies
broad loss of regulatory control of self-tolerance
skin, joints, kidneys
immune complexes involved (type III hypersensitivity)

Question 14

RA

Answer 14

destruction of joint cartilage and inflammation of synovium
TH1, TH17, macrophages, B cells, and plasma cells create inflammatory environment via leukocyte-recruiting cytokines
TNF alpha is involved

Question 15

sjogren’s syndrome

Answer 15

influx of B and T cells into lacrimal and salivary glands

Question 16

scleroderma

Answer 16

hypersensitivity to collagen due to T cells infiltrating dermis
release of IL-1 and TNF alpha stimulate collagen production –> vicious cycle

Question 17

polymyositis-dermatomyositis

Answer 17

muscle injury due to CD4 and CD8 T cells infiltrating muscles
Coxsackie B virus involved