antigen presentation and MHC Flashcards
what region of HLA gene codes for class II MHC proteins
D region of HLA gene
what regions of HLA gene encode for class I MHC proteins
regions A, B, and C
MHC gene expression is
codominant and polymorphic
MHC haplotype
total set of MHC genes on each chromosome
inherit one haplotype from each parent
how many class I and class II genes does an individual receive
3 different class I and 3 different class II genes from EACH parent total of 6 different class I and 6 different class II MHC proteins are inherited
role of MHC proteins
T lymphocytes only respond to antigen when it is expressed on an antigen presenting cell (APC) in conjunction with MHC proteins
narcolepsy gene
HLA-DR2
ankylosing spondylitis gene
HLA-B27
how to increase success of long term graft survival in organ transplantation
match HLA types
immunosuppressive drugs
why is it a problem that RBCs don’t have MHC molecules
in malaria, when RBCs are infected, they cannot alert cytotoxic T cells that they are infected
beta 2 microglobulin is required for
cellular expression of alpha chain in class I MHC without beta 2, can't get MHC I to cell surface
where are MHC proteins
surface of all nucleated cells
not on erythrocytes (no nucleus) or corneal epithelial cells
where are MHC class I proteins
surface of all nucleated cells
not on erythrocytes (no nucleus) or corneal epithelial cells
where are MHC class II proteins
surface of APCs (dendritic cells, macrophages, and B lymphocytes)
polymorphic
multiple variants of each gene exist in population