Autoimmunity

Question 1

Dry Mouth, Dry Eyes, Joint pain, RF +, Anti Ro +, Anti La +, Elevated ESR

Answer 1

Sjogren Syndrome
Increased risk of B cell lymphoma
50% of patients have parotid gland enlargment
High SSA (Anti rho) most indicative of Sjogrens vs SLE
Usually also have dental caries

Question 2

ANA

Answer 2

Anti nuclear antibody

Indicative of Autoimmune reaction

Question 3

Hard firm skin, Fine crackles in lower lungs, Raynauds phenomenon, ANA +, Anti topoisomerase +, anti-DS DNA negative

Answer 3

Systemic Sclerosis
More common in women
Pulmonary fibrosis is leading cause of death
Early: Peripheral edematous change moves proximal
Late: Epidermal atrophy and fibrosis of the dermis

Question 4

Normal Creatinine

Answer 4

0.6 - 1.3 mg/dL

Question 5

Normal protein

Answer 5

6-8 g/dL

Question 6

Normal albumin

Answer 6

3.5-5.5 g/dL

Question 7

Glistening waxy deposits on the heart with increase serum proteins, albumin and creatinine

Answer 7

Amyloidosis

Congo Red Stain turns Apple Green

Question 8

Elevated ESR, ANA Positive, Elevated CPK

Answer 8

Dermatomyositis/Polymyositis

Type IV