Autoimmunity

Question 1

What are the autoimmune disease in MSK

Answer 1

RA
Myasthenia gravis 
Scleroderma 
Polymyositis 
Dermatomyositis 
Lupus 
Sjogrens 
Vasculitis

Question 2

What is Ra

Answer 2

Chronic inflammation of the synovial lining of the joints, tendon sheaths and bursa
Affects small joints first

Question 3

What are the ix of ra

Answer 3

Blood: CRP, anti - CPP antibodies

Xr

Question 4

What type of hypersensitivity reaction causes RA

Answer 4

IV

Question 5

What is the treatment of RA

Answer 5

1st line: immunosuppresion e.g corticosteroids, DMARDS, e.g methotreaxte
2nd biological therapies

Question 6

What is myasthenia gravies

Answer 6

Causes muscles weakness -

Female <40 years and >60 males

Question 7

What is the epidemiology of myathenia gravis

Answer 7

Females < 40

Males > 60

Question 8

Clinical features of graves

Answer 8

Eyelid weakness - dropping of eyelids 
Weakness in facial movement 
Dysphagia 
Slurred speech 
Progressive weakness with repetitive movements

Question 9

Ix of graves

Answer 9

Presence of auto reactive antibodies in serum :

• anti - AChR antibodies
• anti MuSK antibodies
• anti LRP4 antibodies

Question 10

Treatment for grave

Answer 10

1st line: reversible anti - cholinesterase ( pyridotigmine)
2nd : immunosuppressant e.g. corticosteroids, azathioprine
Surgery for thyroidectomy
Severe; 02, plasmapheresis