autoimmune liver disease

Question 1

What is the definition of autoimmune hepatitis?

Answer 1

a rare chronic hepatitis autoimmune in origin

Question 2

What is autoimmune hepatitis associated with?

Answer 2

Associated with other autoimmune conditions

1. Rheumatoid arthritis
2. Hashimoto’s thyroiditis
3. Diabetes mellitus

Question 3

Describe the epidemiology of autoimmune hepatitis?|

Answer 3

1. Bimodal distribution
   10-20 years and 45-70
2. 75% of the time in women

Question 4

How may autoimmune hepatitis present?

Answer 4

1. non specific symptoms
   fatigue, abdominal pain and weightloss
2. acute liver failure (1/3)

Question 5

What are the symptoms of acute liver failure?

Answer 5

Fever
Jaundice
RUQ pain

Question 6

Describe type 1 autoimmue liver disease?

Answer 6

1. affects both adults and children
2. anti nuclear antibodies
3. anti smooth muscle antibodies

Question 7

Describe type 2 autoimmune liver disease?

Answer 7

1. affects children only

2. anti liver/kidney micrososmal type 1 antibodies (LKM1)

Question 8

Name 3 differential diagnosis?

Answer 8

1. Viral hepatitis
2. Primary schlerosing cholangitis
3. Primary billiary cirrhosis